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Study · Non-randomized trial · n = 12 · 1998

8 results

Hexarelin, a synthetic GH-releasing peptide, is a powerful stimulus of GH secretion in pubertal children and in adults but not in prepubertal children and in elderly subjects.

Bellone J, Bartolotta E, Sgattoni C, Aimaretti G, Arvat E, Bellone S, Deghenghi R, Ghigo E

Journal of endocrinological investigation1 Sept 1998Cited by 5 (Europe PMC)

PMID9801989 (opens in a new tab)DOI10.1007/bf03347334 (opens in a new tab)PepBankPUB-09801989
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In young adults, the GH response to hexarelin was similar to that to arginine plus GHRH.

    In plain wordsIn young adults, hexarelin gave a similar growth hormone rise to arginine plus GHRH.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin versus arginine plus GHRH, young adults
    Study

    n = 12

    Comparator
    Arginine plus GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    60.9 micrograms/l
    hexarelin
    Peak GH
    68.9 micrograms/l
    arginine plus GHRH

    Source sentences

    Summary
    In young adults, the GH response to HEX 60.9 +/- 8.0 micrograms/l; 2401.0 +/- 376.2 micrograms/l/h) was similar to that to ARG + GHRH (68.9 +/- 11.7 micrograms/l; 3035.7 +/- 466.6 micrograms/l/h) and both were clearly higher (p < 0.001) than that to GHRH alone (21.6 +/- 3.6 micrograms/l; 790.0 +/- 1…
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  2. 02HumanNon-randomized trialEfficacy outcome

    In young adults, the GH response to hexarelin was clearly higher than that to GHRH alone.

    In plain wordsIn young adults, hexarelin gave a clearly higher growth hormone rise than GHRH alone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin versus GHRH alone, young adults
    Study

    n = 12

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    60.9 micrograms/l
    hexarelin
    Peak GH
    21.6 micrograms/l
    GHRH alone

    Source sentences

    Summary
    In young adults, the GH response to HEX 60.9 +/- 8.0 micrograms/l; 2401.0 +/- 376.2 micrograms/l/h) was similar to that to ARG + GHRH (68.9 +/- 11.7 micrograms/l; 3035.7 +/- 466.6 micrograms/l/h) and both were clearly higher (p < 0.001) than that to GHRH alone (21.6 +/- 3.6 micrograms/l; 790.0 +/- 1…
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  3. 03HumanNon-randomized trialEfficacy outcome

    In elderly subjects, the GH response to hexarelin was higher than that to GHRH.

    In plain wordsIn elderly people, hexarelin gave a higher growth hormone rise than GHRH.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin versus GHRH, elderly subjects
    Study

    n = 12

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    22.4 micrograms/l
    hexarelin
    Peak GH
    3.6 micrograms/l
    GHRH

    Source sentences

    Summary
    In elderly subjects, the GH response to HEX (22.4 +/- 4.9; 855.0 +/- 199.0 micrograms/l/h) was higher (p < 0.01) than that to GHRH (3.6 +/- 0.8 micrograms/l; 151.8 +/- 24.6 micrograms/l/h) but lower (p < 0.05) than that to ARG + GHRH (48.1 +/- 4.6 micrograms/l; 1758.2 +/- 149.1 micrograms/l/h).
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  4. 04HumanNon-randomized trialEfficacy outcome

    In elderly subjects, the GH response to hexarelin was lower than that to arginine plus GHRH.

    In plain wordsIn elderly people, hexarelin gave a lower growth hormone rise than arginine plus GHRH.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin versus arginine plus GHRH, elderly subjects
    Study

    n = 12

    Comparator
    Arginine plus GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    22.4 micrograms/l
    hexarelin
    Peak GH
    48.1 micrograms/l
    arginine plus GHRH

    Source sentences

    Summary
    In elderly subjects, the GH response to HEX (22.4 +/- 4.9; 855.0 +/- 199.0 micrograms/l/h) was higher (p < 0.01) than that to GHRH (3.6 +/- 0.8 micrograms/l; 151.8 +/- 24.6 micrograms/l/h) but lower (p < 0.05) than that to ARG + GHRH (48.1 +/- 4.6 micrograms/l; 1758.2 +/- 149.1 micrograms/l/h).
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  5. 05HumanNon-randomized trialEfficacy outcome

    In prepubertal children with normal short stature, the GH response to hexarelin was lower than that to GHRH, but the difference was not significant.

    In plain wordsIn prepubertal children, hexarelin gave a lower growth hormone rise than GHRH, but the difference was not significant.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin versus GHRH, prepubertal children
    Study

    n = 6

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    19 micrograms/l
    hexarelin
    Peak GH
    27.4 micrograms/l
    GHRH

    Source sentences

    Summary
    In prepubertal children, the GH response to HEX (19.0 +/- 4.6 micrograms/l; 611.5 +/- 121.4 micrograms/l/h) was lower than that to GHRH (27.4 +/- 12.7 micrograms/l; 1209.0 +/- 590.9 micrograms/l/h) but this difference did not attain statistical significance.
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  6. 06HumanNon-randomized trialEfficacy outcome

    In prepubertal children, the GH response to hexarelin was lower than that to arginine plus GHRH.

    In plain wordsIn prepubertal children, hexarelin gave a lower growth hormone rise than arginine plus GHRH.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin versus arginine plus GHRH, prepubertal children
    Study

    n = 6

    Comparator
    Arginine plus GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    19 micrograms/l
    hexarelin
    Peak GH
    57.9 micrograms/l
    arginine plus GHRH

    Source sentences

    Summary
    In prepubertal children, the GH response to HEX (19.0 +/- 4.6 micrograms/l; 611.5 +/- 121.4 micrograms/l/h) was lower than that to GHRH (27.4 +/- 12.7 micrograms/l; 1209.0 +/- 590.9 micrograms/l/h) but this difference did not attain statistical significance. Both these responses were, in turn, lower…
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  7. 07HumanNon-randomized trialEfficacy outcome

    In pubertal children, the GH response to hexarelin was higher than that to arginine plus GHRH, but the difference was not significant.

    In plain wordsIn pubertal children, hexarelin gave a higher growth hormone rise than arginine plus GHRH, but the difference was not significant.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin versus arginine plus GHRH, pubertal children
    Study

    n = 6

    Comparator
    Arginine plus GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    67.6 micrograms/l
    hexarelin
    Peak GH
    49.1 micrograms/l
    arginine plus GHRH

    Source sentences

    Summary
    In pubertal children, the GH response to HEX (67.6 +/- 12.7 micrograms/l; 2755.3 +/- 547.3 micrograms/l/h) was higher than that to ARG + GHRH (49.1 +/- 8.9 micrograms/l; 2554.1 +/- 356.6 micrograms/l/h) but this difference did not attain statistical significance
    2 context sentences
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).
  8. 08HumanNon-randomized trialEfficacy outcome

    In pubertal children, the GH response to hexarelin was clearly higher than that to GHRH alone.

    In plain wordsIn pubertal children, hexarelin gave a clearly higher growth hormone rise than GHRH alone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin versus GHRH alone, pubertal children
    Study

    n = 6

    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    67.6 micrograms/l
    hexarelin
    Peak GH
    23.1 micrograms/l
    GHRH alone

    Source sentences

    Summary
    In pubertal children, the GH response to HEX (67.6 +/- 12.7 micrograms/l
    3 context sentences
    Summary · context
    both these responses were, in turn, clearly higher (p < 0.05) than that to GHRH alone (23.1 +/- 7.9 micrograms/l
    Summary · context
    We compared the GH response to the maximal effective dose of Hexarelin (2 micrograms/kg i.v.), an hexapeptide belonging to GHRP family, with that of GHRH (1 microgram/kg i.v.) alone and combined with arginine (ARG, 0.5 g/kg i.v.), which likely acts via inhibition of hypothalamic somatostatin release.
    Summary · context
    We studied 6 prepubertal (4 boys and 2 girls, age 2.6-12.2 yr) and 6 pubertal children with normal short stature (3 boys and 3 girls, age 10.3-14.4 yr) as well as 12 normal young adults (6 males and 6 females, age 22-30 yr) and 12 normal elderly subjects (6 males and 6 females, age 53-79 yr).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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