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Study · Animal study (in vivo) · rat · 1998

1 result

Nephrectomy decreases amylin and pramlintide clearance in rats.

Vine W, Smith P, LaChappell R, Blase E, Lumpkin R, Young A

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme1 Aug 1998Cited by 14 (Europe PMC)

PMID9761382 (opens in a new tab)DOI10.1055/s-2007-978923 (opens in a new tab)PepBankPUB-09761382
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, nephrectomy decreased pramlintide clearance.

    In plain wordsIn rats, removal of kidney function decreased pramlintide clearance.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreasePramlintide clearance after nephrectomy
    Study

    ratn: not reported in source

    Functionally nephrectomized rats
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Title
    Nephrectomy decreases amylin and pramlintide clearance in rats.
    1 context sentence
    Summary · context
    Because the human amylin analog, pramlintide, is being tested in patients with diabetes mellitus, a known risk factor for nephropathy, we examined the role of the kidney on amylin and pramlintide metabolism and action in functionally nephrectomized rats.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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