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Study · Not a test of the peptide alone · 1998

3 results

Degradation kinetics of three gonadorelin analogues: developing a method for calculating epimerization parameters.

Hoitink MA, Beijnen JH, Boschma MU, Bult A, van der Houwen OA, Wiese G, Underberg WJ

Pharmaceutical research1 Sept 1998Cited by 9 (Europe PMC)

PMID9755899 (opens in a new tab)DOI10.1023/a:1011966024778 (opens in a new tab)PepBankPUB-09755899
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

  1. 01LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In buffer solutions, explicit structure-degradation mechanism relations were found for the gonadorelin analogues buserelin, goserelin and triptorelin.

    In plain wordsIn lab tests, how three gonadorelin analogues break down depended clearly on their structure.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableStructure-degradation relations
    Study

    n: not reported in source

    buffer solutions
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    Explicit structure-degradation mechanism relations were found in the degradation of all three compounds.
    1 context sentence
    Summary · context
    The influences of pH, temperature, and buffer concentration on the degradation of the three gonadorelin analogues buserelin, goserelin, and triptorelin were investigated using RP-HPLC.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  2. 02LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In buffer solutions, the L-serine residue was involved in backbone hydrolysis and in hydroxyl-catalysed epimerisation, whereas the O-tertiary butyl D-serine residue was involved only in proton-catalysed ether hydrolysis.

    In plain wordsIn lab tests, the L-serine part of these analogues broke down in two ways, and the O-tertiary butyl D-serine part in one way.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableRole of serine residues in degradation
    Study

    n: not reported in source

    buffer solutions
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The L-serine residue was found to be involved in both a solvent-catalysed backbone hydrolysis and a hydroxyl-catalysed epimerisation whereas, the O-tertiary butyl D-serine residue was only involved in proton-catalysed ether hydrolysis.
    1 context sentence
    Summary · context
    The influences of pH, temperature, and buffer concentration on the degradation of the three gonadorelin analogues buserelin, goserelin, and triptorelin were investigated using RP-HPLC.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  3. 03LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In buffer solutions, the kinetics of identical reactions in different gonadorelin analogues were generally comparable.

    In plain wordsIn lab tests, the same breakdown reactions ran at similar rates in the different gonadorelin analogues.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableComparability of degradation kinetics across analogues
    Study

    n: not reported in source

    buffer solutions
    Outcome group
    Formulation, delivery and stability · Pharmacology

    Source sentences

    Summary
    The kinetics of identical reactions in different analogues were generally comparable.
    1 context sentence
    Summary · context
    The influences of pH, temperature, and buffer concentration on the degradation of the three gonadorelin analogues buserelin, goserelin, and triptorelin were investigated using RP-HPLC.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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