Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C, Balsano F

Metabolism: clinical and experimental1 Aug 1998Cited by 56 (Europe PMC)

PMID9711998DOI10.1016/s0026-0495(98)90357-2PepBankPUB-09711998

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialMechanism
Across diabetic patients and controls, GSH/GSSG ratio increments correlated positively with glucose uptake increments after glutathione infusion.
In plain wordsIn diabetic patients and controls, larger redox ratio increases after glutathione infusion were linked to larger glucose uptake increases.
Peptide
Glutathione
Outcome
IncreaseCorrelation of redox and glucose uptake increments
Study
n = 20
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1.35 g x m2 x min(-1) · intravenous · 1 hourAs given in this study (human).
Measurements
Correlation coefficient r
0.518
pooled diabetic patients and controls, increments in GSH/GSSG ratio versus increments in glucose uptake after GSH infusion
P value
< 0.05
Correlation between GSH/GSSG ratio increments and glucose uptake increments after GSH infusion, pooled diabetic patients and controls
Source sentences
Summary
Pooling diabetic patients and controls, significant correlations were found between intraerythrocytic GSH/GSSG ratio and total glucose uptake (r = .425, P < .05), as well as between increments of the same variables after GSH infusion (r = .518, P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
Report a problemFND-0971199807
02HumanRandomized controlled trialEfficacy outcome
In healthy subjects, glutathione increased total glucose uptake, whereas saline had no effect.
In plain wordsIn healthy subjects, glutathione increased glucose uptake compared with ineffective saline.
Peptide
Glutathione
Outcome
IncreaseGlucose uptake in healthy subjects
Study
n = 10
Comparator
Saline
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1.35 g x m2 x min(-1) · intravenous · 1 hourAs given in this study (human).
Measurements
Total glucose uptake
37.1 micromol kg(-1) x min(-1)
healthy subjects, before GSH infusion
Total glucose uptake reported +/- uncertainty (type unspecified)
6.7 micromol kg(-1) x min(-1)
healthy subjects, before GSH infusion
Total glucose uptake
39.5 micromol x kg(-1) x min(-1)
healthy subjects, after GSH infusion
Total glucose uptake reported +/- uncertainty (type unspecified)
7.7 micromol x kg(-1) x min(-1)
healthy subjects, after GSH infusion
P value
< 0.05
Total glucose uptake: after versus before GSH infusion in healthy subjects
Source sentences
Summary
In the same subjects, GSH infusion significantly increased total glucose uptake (from 37.1 +/- 6.7 micromol kg(-1) x min(-1) to 39.5 +/- 7.7 micromol x kg(-1) x min(-1), P < .05), whereas saline infusion was completely ineffective.
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
Report a problemFND-0971199802
03HumanRandomized controlled trialMechanism
In healthy subjects, glutathione infusion significantly increased the intraerythrocytic GSH/GSSG ratio.
In plain wordsIn healthy subjects, glutathione infusion increased the redox ratio in red blood cells from baseline.
Peptide
Glutathione
Outcome
IncreaseGSH/GSSG ratio in healthy subjects
Study
n = 10
Outcome group
Oxidative stress · Metabolic and weight
Studied dose
1.35 g x m2 x min(-1) · intravenous · 1 hourAs given in this study (human).
Measurements
Intraerythrocytic GSH/GSSG ratio
21
healthy subjects, before GSH infusion
Intraerythrocytic GSH/GSSG ratio reported +/- uncertainty (type unspecified)
0.9
healthy subjects, before GSH infusion
Intraerythrocytic GSH/GSSG ratio
24.7
healthy subjects, after GSH infusion
Intraerythrocytic GSH/GSSG ratio reported +/- uncertainty (type unspecified)
1.3
healthy subjects, after GSH infusion
P value
< 0.05
Intraerythrocytic GSH/GSSG ratio: after versus before GSH infusion in healthy subjects
Source sentences
Summary
In addition, the mean intraerythrocytic GSH/GSSG ratio significantly increased after GSH infusion (from 21.0 +/- 0.9 to 24.7 +/- 1.3, P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
Report a problemFND-0971199803
04HumanRandomized controlled trialEfficacy outcome
In patients with NIDDM, glutathione infusion significantly increased total glucose uptake.
In plain wordsIn patients with diabetes, glutathione infusion increased glucose uptake from baseline.
Peptide
Glutathione
Outcome
IncreaseGlucose uptake in diabetic patients
Study
n = 10
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1.35 g x m2 x min(-1) · intravenous · 1 hourAs given in this study (human).
Measurements
Total glucose uptake
25.3 micromol x kg(-1) x min(-1)
diabetic patients, before GSH infusion
Total glucose uptake reported +/- uncertainty (type unspecified)
9 micromol x kg(-1) x min(-1)
diabetic patients, before GSH infusion
Total glucose uptake
31.4 micromol x kg(-1) x min(-1)
diabetic patients, after GSH infusion
Total glucose uptake reported +/- uncertainty (type unspecified)
10 micromol x kg(-1) x min(-1)
diabetic patients, after GSH infusion
P value
< 0.001
Total glucose uptake: after versus before GSH infusion in diabetic patients
Source sentences
Summary
Similar findings were found in diabetic patients, in whom GSH infusion significantly increased both total glucose uptake (from 25.3 +/- 9.0 micromol x kg(-1) x min(-1) to 31.4 +/- 10.0 micromol x kg(-1) x min(-1), P < .001) and intraerythrocytic GSH/GSSG ratio (from 14.8 +/- 4.1 to 21.7 +/- 6.7, P < .01).
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
Report a problemFND-0971199804
05HumanRandomized controlled trialMechanism
In patients with NIDDM, glutathione infusion significantly increased the intraerythrocytic GSH/GSSG ratio.
In plain wordsIn patients with diabetes, glutathione infusion increased the redox ratio in red blood cells from baseline.
Peptide
Glutathione
Outcome
IncreaseGSH/GSSG ratio in diabetic patients
Study
n = 10
Outcome group
Oxidative stress · Metabolic and weight
Studied dose
1.35 g x m2 x min(-1) · intravenous · 1 hourAs given in this study (human).
Measurements
Intraerythrocytic GSH/GSSG ratio
14.8
diabetic patients, before GSH infusion
Intraerythrocytic GSH/GSSG ratio reported +/- uncertainty (type unspecified)
4.1
diabetic patients, before GSH infusion
Intraerythrocytic GSH/GSSG ratio
21.7
diabetic patients, after GSH infusion
Intraerythrocytic GSH/GSSG ratio reported +/- uncertainty (type unspecified)
6.7
diabetic patients, after GSH infusion
P value
< 0.01
Intraerythrocytic GSH/GSSG ratio: after versus before GSH infusion in diabetic patients
Source sentences
Summary
Similar findings were found in diabetic patients, in whom GSH infusion significantly increased both total glucose uptake (from 25.3 +/- 9.0 micromol x kg(-1) x min(-1) to 31.4 +/- 10.0 micromol x kg(-1) x min(-1), P < .001) and intraerythrocytic GSH/GSSG ratio (from 14.8 +/- 4.1 to 21.7 +/- 6.7, P < .01).
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
Report a problemFND-0971199805

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

06HumanEndogenous levelObservational studyOther
In patients with NIDDM, baseline intraerythrocytic GSH/GSSG ratio was lower than in healthy subjects.
In plain wordsIn patients with diabetes, the body's own glutathione redox ratio was lower than in healthy subjects.
Peptide
Glutathione
Outcome
DecreaseBaseline GSH/GSSG ratio
Study
n = 20
Comparator
Healthy subjects
Outcome group
Oxidative stress · Metabolic and weight
Source sentences
Summary
In healthy subjects, baseline intraerythrocytic GSH/GSSG ratio (P < .0005) and total glucose uptake (P < .005) were significantly higher than in NIDDM patients.
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
This result measures the body's own Glutathione. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0971199801
07HumanEndogenous levelObservational studyMechanism
Across diabetic patients and controls, intraerythrocytic GSH/GSSG ratio correlated positively with total glucose uptake.
In plain wordsIn diabetic patients and controls, the body's own glutathione redox ratio was linked to higher glucose uptake.
Peptide
Glutathione
Outcome
IncreaseGSH/GSSG ratio association with glucose uptake
Study
n = 20
Outcome group
Glycemic control · Metabolic and weight
Measurements
Correlation coefficient r
0.425
pooled diabetic patients and controls, intraerythrocytic GSH/GSSG ratio versus total glucose uptake
P value
< 0.05
Correlation between intraerythrocytic GSH/GSSG ratio and total glucose uptake, pooled diabetic patients and controls
Source sentences
Summary
Pooling diabetic patients and controls, significant correlations were found between intraerythrocytic GSH/GSSG ratio and total glucose uptake (r = .425, P < .05), as well as between increments of the same variables after GSH infusion (r = .518, P < .05).
3 context sentences(design, population, supporting numbers)
Summary · context
To evaluate the relationship between oxidative stress and glucose metabolism, insulin sensitivity and intraerythrocytic reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio were measured in 10 non-insulin-dependent diabetes mellitus (NIDDM) patients and 10 healthy subjects before and after th…
Summary · context
In particular, after baseline insulin sensitivity was assessed by a 2-hour euglycemic hyperinsulinemic clamp, either glutathione (1.35 g x m2 x min(-1)) or placebo (saline) were infused over a period of 1 hour.
Summary · context
The same protocol was repeated at a 1-week interval, in cross-over, according to a randomized, single-blind design.
This result measures the body's own Glutathione. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0971199806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedNot applicableNCT02948673

The Production of Reactive Oxygen Species in Response to Glutathione Supplementation and Acute Exercise

University of Copenhagenn = 20May 2016 to Dec 2017

Type 2 Diabetes · Oxidative Stress · Mitochondrial Reactive Oxygen Species Production

Trial page ClinicalTrials.govUpdated 2 May 2018

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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