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Study · Animal study (in vivo) · rat · 1998

4 results

Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin.

Desaphy JF, De Luca A, Pierno S, Imbrici P, Camerino DC

The Journal of pharmacology and experimental therapeutics1 Aug 1998Cited by 12 (Europe PMC)

PMID9694949 (opens in a new tab)DOI10.1016/s0022-3565(24)37668-2 (opens in a new tab)PepBankPUB-09694949
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, chronic hexarelin restored the current kinetics of skeletal muscle sodium channels.

    In plain wordsIn aged rats, hexarelin treatment restored the way muscle sodium channel currents behave.

    Peptide
    Hexarelin
    Outcome
    Direction not reportedSkeletal muscle sodium channel current kinetics in aged rats
    Study

    ratn: not reported in source

    Patch-clamp of fast-twitch muscle fibers from aged rats
    Comparator
    Untreated aged rats
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Chronic treatment of aged rats with either GH or hexarelin restored current kinetics
    1 context sentence
    Summary · context
    This study was aimed at investigating the effects of chronic treatment of aged rats with growth hormone (GH, 8 weeks) or the GH-secretagogue hexarelin (4 weeks) on the biophysical modifications that voltage-gated sodium channels of skeletal muscle undergo during aging, by means of the patch-clamp te…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, chronic hexarelin did not restore sodium channel conductance.

    In plain wordsIn aged rats, hexarelin treatment did not restore muscle sodium channel conductance.

    Peptide
    Hexarelin
    Outcome
    No significant changeSkeletal muscle sodium channel conductance in aged rats
    Study

    ratn: not reported in source

    Patch-clamp of fast-twitch muscle fibers from aged rats
    Comparator
    Untreated aged rats
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Chronic treatment of aged rats with either GH or hexarelin restored current kinetics but not channel conductance
    1 context sentence
    Summary · context
    This study was aimed at investigating the effects of chronic treatment of aged rats with growth hormone (GH, 8 weeks) or the GH-secretagogue hexarelin (4 weeks) on the biophysical modifications that voltage-gated sodium channels of skeletal muscle undergo during aging, by means of the patch-clamp te…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, chronic hexarelin did not restore sodium channel density.

    In plain wordsIn aged rats, hexarelin treatment did not restore the number of sodium channels in muscle.

    Peptide
    Hexarelin
    Outcome
    No significant changeSkeletal muscle sodium channel density in aged rats
    Study

    ratn: not reported in source

    Patch-clamp of fast-twitch muscle fibers from aged rats
    Comparator
    Untreated aged rats
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Chronic treatment of aged rats with either GH or hexarelin restored current kinetics but not channel conductance and density
    1 context sentence
    Summary · context
    This study was aimed at investigating the effects of chronic treatment of aged rats with growth hormone (GH, 8 weeks) or the GH-secretagogue hexarelin (4 weeks) on the biophysical modifications that voltage-gated sodium channels of skeletal muscle undergo during aging, by means of the patch-clamp te…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged rats, hexarelin restored the firing capacity of fast-twitch muscle fibers.

    In plain wordsIn aged rats, hexarelin treatment restored the firing ability of fast muscle fibers.

    Peptide
    Hexarelin
    Outcome
    IncreaseFiring capacity of fast-twitch muscle fibers in aged rats
    Study

    ratn: not reported in source

    Patch-clamp of fast-twitch muscle fibers from aged rats
    Comparator
    Untreated aged rats
    Outcome group
    Aging markers · Musculoskeletal
    Studied dose
    Dose not stated · 4 weeksAs given in this study (rat).

    Source sentences

    Summary
    Moreover, hexarelin restored the firing capacity of fast-twitch muscle fibers
    1 context sentence
    Summary · context
    This study was aimed at investigating the effects of chronic treatment of aged rats with growth hormone (GH, 8 weeks) or the GH-secretagogue hexarelin (4 weeks) on the biophysical modifications that voltage-gated sodium channels of skeletal muscle undergo during aging, by means of the patch-clamp te…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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