In rats, a lipid matrix of soybean phosphatidyl choline and medium-chain monoacylglycerol increased the jejunal permeability of hexarelin about 20-fold, with and without a protease inhibitor.
In plain wordsIn rats, a lipid delivery system raised the gut wall passage of hexarelin in the jejunum about 20-fold.
- Peptide
- Hexarelin
- Outcome
- IncreaseJejunal effective permeability of hexarelin with PC-MG
- Study
ratn: not reported in source
In situ rat intestinal permeability- Comparator
- Without PC-MG
- Outcome group
- Pharmacokinetics · Pharmacology
Measurements
- Jejunal Peff increase
- ≈ 20 fold
- hexarelin with 15 mmol L(-1) PC-MG
Source sentences
PC-MG at a concentration of 15 mmol L(-1) increased the jejunal Peff of hexarelin approximately 20-fold, both in the presence and absence of Pefabloc SC
1 context sentence(design, population, supporting numbers)
The aim of this study was to investigate if the effective in-situ permeability (Peff) of a new growth hormone-releasing peptide, hexarelin, along rat intestine was enhanced by a lipid matrix drug-delivery system comprising a mixture of soybean phosphatidyl choline and medium-chain monoacylglycerol (PC-MG).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.