Lack of effect of hexarelin on TRH-induced TSH response in normal adult man.

Arosio M, Casati G, Biella O, Porretti S, Imbimbo BP, Faglia G

Journal of endocrinological investigation1 Apr 1998Cited by 1 (Europe PMC)

PMID9624598DOI10.1007/bf03347309PepBankPUB-09624598

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. 5 results from people.

01HumanNon-randomized trialEfficacy outcome
In normal adults, hexarelin with placebo significantly increased serum GH.
In plain wordsIn healthy adults, hexarelin raised growth hormone in the blood.
Peptide
Hexarelin
Outcome
IncreaseSerum GH after hexarelin with placebo
Study
n = 7
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/Kg bw · intravenousAs given in this study (human).
Source sentences
Summary
Hexarelin induced significant and similar increases in serum GH levels when given in combination either with placebo or with TRH (1217 +/- 470 vs 986 +/- 208 micrograms/min/l p:NS)
1 context sentence(design, population, supporting numbers)
Summary · context
Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration.
Report a problemFND-0962459801
02HumanNon-randomized trialEfficacy outcome
In normal adults, hexarelin with placebo did not change serum TSH.
In plain wordsIn healthy adults, hexarelin did not change blood TSH levels.
Peptide
Hexarelin
Outcome
No significant changeBasal serum TSH after hexarelin with placebo
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/Kg bw · intravenousAs given in this study (human).
Source sentences
Summary
Serum TSH levels were unmodified by hexarelin + placebo injection.
1 context sentence(design, population, supporting numbers)
Summary · context
Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration.
Report a problemFND-0962459803
03HumanNon-randomized trialEfficacy outcome
In normal adults, the TSH increase after hexarelin plus TRH was equal to that after TRH plus placebo.
In plain wordsIn healthy adults, hexarelin did not change the TSH rise caused by TRH.
Peptide
Hexarelin
Outcome
No significant changeTRH-stimulated TSH response with hexarelin
Study
n = 7
Comparator
TRH plus placebo
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/Kg bw · intravenousAs given in this study (human).
Measurements
TSH response
1124 mU/min/l
hexarelin plus TRH
TSH response
1273 mU/min/l
TRH plus placebo
Source sentences
Summary
The TSH increase elicited by hexarelin + TRH was superimposable to that elicited by TRH + placebo (1124 +/- 530 and 1273 +/- 380 mU/min/l respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration.
Report a problemFND-0962459804
04HumanNon-randomized trialEfficacy outcome
In normal adults, circulating PRL increased slightly after hexarelin with placebo.
In plain wordsIn healthy adults, hexarelin slightly raised prolactin.
Peptide
Hexarelin
Outcome
IncreaseCirculating PRL after hexarelin with placebo
Study
n = 7
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/Kg bw · intravenousAs given in this study (human).
Measurements
PRL response
897 micrograms/min/l
hexarelin plus placebo
Source sentences
Summary
Circulating PRL levels slightly increased after hexarelin + placebo too (897 micrograms/min/l)
1 context sentence(design, population, supporting numbers)
Summary · context
Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration.
Report a problemFND-0962459805
05HumanNon-randomized trialEfficacy outcome
In normal adults, the PRL response to hexarelin plus TRH was slightly but not significantly greater than that after TRH plus placebo.
In plain wordsIn healthy adults, hexarelin with TRH gave a slightly larger, not significant, prolactin rise than TRH alone.
Peptide
Hexarelin
Outcome
No significant changePRL response to TRH with hexarelin
Study
n = 7
Comparator
TRH plus placebo
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
1 microgram/Kg bw · intravenousAs given in this study (human).
Measurements
PRL response
2680 micrograms/min/l
hexarelin plus TRH
PRL response
2243 micrograms/min/l
TRH plus placebo
Source sentences
Summary
and the PRL response to hexarelin + TRH was slightly, although not significantly, greater than that observed after TRH + placebo (2680 +/- 1517 and 2243 +/- 1108 micrograms/min/l, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration.
Report a problemFND-0962459806

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In normal adults, the GH response to hexarelin plus TRH was similar to that of hexarelin plus placebo.
In plain wordsIn healthy adults, adding TRH did not change the growth hormone rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeGH response to hexarelin with TRH versus with placebo
Study
n = 7
Comparator
Hexarelin plus placebo
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
1217 micrograms/min/l
hexarelin plus placebo
GH response
986 micrograms/min/l
hexarelin plus TRH
Source sentences
Summary
Hexarelin induced significant and similar increases in serum GH levels when given in combination either with placebo or with TRH (1217 +/- 470 vs 986 +/- 208 micrograms/min/l p:NS)
1 context sentence(design, population, supporting numbers)
Summary · context
Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0962459802

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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