Dopaminergic modulation of hexarelin-induced GH and PRL secretion in hyperprolactinemia.

Foppiani L, Giusti M, Sessarego P, Guido R

Recenti progressi in medicina1 Mar 1998

PMID9586422PepBankPUB-09586422

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialEfficacy outcome
In women with hyperprolactinemia and in controls, hexarelin induced a slight but significant prolactin release.
In plain wordsIn women with high prolactin and in controls, hexarelin caused a small rise in prolactin.
Peptide
Hexarelin
Outcome
IncreasePRL release after hexarelin
Study
n = 17
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2 micrograms/kg/bw · intravenousAs given in this study (human).
Source sentences
Summary
Hex was able to induce a slight but significant (p < 0.05) PRL release in both groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The aims of this study were to investigate the effect of Hex on GH and PRL secretion in 10 hyperprolactinemic women (HPRL) and 7 controls (C).
Summary · context
All subjects underwent stimulus testing with placebo, bromocriptine (Br) (2.5 mg po at time -60), Hex (2 micrograms/kg/bw i.v.), and Br plus Hex.
Report a problemFND-0958642201
02HumanNon-randomized trialEfficacy outcome
In women with hyperprolactinemia and in controls, hexarelin induced a significant growth hormone release.
In plain wordsIn women with high prolactin and in controls, hexarelin raised growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH release after hexarelin
Study
n = 17
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg/bw · intravenousAs given in this study (human).
Source sentences
Summary
Hex induced a significant (p < 0.01) GH release both in HPRL and in C.
2 context sentences(design, population, supporting numbers)
Summary · context
The aims of this study were to investigate the effect of Hex on GH and PRL secretion in 10 hyperprolactinemic women (HPRL) and 7 controls (C).
Summary · context
All subjects underwent stimulus testing with placebo, bromocriptine (Br) (2.5 mg po at time -60), Hex (2 micrograms/kg/bw i.v.), and Br plus Hex.
Report a problemFND-0958642202

Studies that did not test the peptide alone4

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

03HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In women with hyperprolactinemia, bromocriptine priming abolished the prolactin response to hexarelin.
In plain wordsIn women with high prolactin, bromocriptine given first removed the prolactin rise caused by hexarelin.
Peptide
Hexarelin
Outcome
DecreasePRL response to hexarelin after bromocriptine priming, hyperprolactinemic women
Study
n = 10
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
PRL response to Hex was abolished (p < 0.01 vs Hex) by Br priming in HPRL
2 context sentences(design, population, supporting numbers)
Summary · context
The aims of this study were to investigate the effect of Hex on GH and PRL secretion in 10 hyperprolactinemic women (HPRL) and 7 controls (C).
Summary · context
All subjects underwent stimulus testing with placebo, bromocriptine (Br) (2.5 mg po at time -60), Hex (2 micrograms/kg/bw i.v.), and Br plus Hex.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0958642203
04HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In women with hyperprolactinemia, bromocriptine priming did not modify the growth hormone response to hexarelin.
In plain wordsIn women with high prolactin, bromocriptine given first did not change the growth hormone rise caused by hexarelin.
Peptide
Hexarelin
Outcome
No significant changeGH response to hexarelin after bromocriptine priming, hyperprolactinemic women
Study
n = 10
Comparator
Hexarelin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Br priming did not modify GH response to Hex in HPRL
2 context sentences(design, population, supporting numbers)
Summary · context
The aims of this study were to investigate the effect of Hex on GH and PRL secretion in 10 hyperprolactinemic women (HPRL) and 7 controls (C).
Summary · context
All subjects underwent stimulus testing with placebo, bromocriptine (Br) (2.5 mg po at time -60), Hex (2 micrograms/kg/bw i.v.), and Br plus Hex.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0958642205
05HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In control women, bromocriptine priming blunted the prolactin response to hexarelin.
In plain wordsIn control women, bromocriptine given first reduced the prolactin rise caused by hexarelin.
Peptide
Hexarelin
Outcome
DecreasePRL response to hexarelin after bromocriptine priming, controls
Study
n = 7
Comparator
Hexarelin alone
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
while it was only blunted (p < 0.05 vs Hex) in C.
2 context sentences(design, population, supporting numbers)
Summary · context
The aims of this study were to investigate the effect of Hex on GH and PRL secretion in 10 hyperprolactinemic women (HPRL) and 7 controls (C).
Summary · context
All subjects underwent stimulus testing with placebo, bromocriptine (Br) (2.5 mg po at time -60), Hex (2 micrograms/kg/bw i.v.), and Br plus Hex.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0958642204
06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome
In control women, bromocriptine priming slightly increased the growth hormone response to hexarelin.
In plain wordsIn control women, bromocriptine given first slightly raised the growth hormone rise caused by hexarelin.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin after bromocriptine priming, controls
Study
n = 7
Comparator
Hexarelin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
while it slightly (p < 0.05) increased GH response to Hex in C
2 context sentences(design, population, supporting numbers)
Summary · context
The aims of this study were to investigate the effect of Hex on GH and PRL secretion in 10 hyperprolactinemic women (HPRL) and 7 controls (C).
Summary · context
All subjects underwent stimulus testing with placebo, bromocriptine (Br) (2.5 mg po at time -60), Hex (2 micrograms/kg/bw i.v.), and Br plus Hex.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0958642206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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