Skip to content

Study · Non-randomized trial · n = 16 · 1998

3 results

Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress.

Ceriello A, Falleti E, Motz E, Taboga C, Tonutti L, Ezsol Z, Gonano F, Bartoli E

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme1 Mar 1998Cited by 101 (Europe PMC)

PMID9566857 (opens in a new tab)DOI10.1055/s-2007-978854 (opens in a new tab)PepBankPUB-09566857
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In diabetic patients and healthy controls, glutathione abolished the circulating ICAM-1 increase during oral glucose testing.

    In plain wordsIn diabetic patients and healthy controls, glutathione prevented the ICAM-1 increase compared with glucose testing alone.

    Peptide
    Glutathione
    Outcome
    DecreaseGlucose-induced circulating ICAM-1 increase
    Study

    n = 16

    Comparator
    Oral glucose tolerance test alone
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intravenous · two hAs given in this study (human).

    Source sentences

    Summary
    Glutathione administration during the oral glucose tolerance test abolished this phenomenon.
    2 context sentences
    Summary · context
    During the oral glucose tolerance test, circulating ICAM-1 plasma levels significantly increased in both diabetic and normal subjects.
    Summary · context
    In this study, three different experiments were performed in nine NIDDM patients and in seven matched healthy controls: oral glucose tolerance test, antioxidant glutathione i.v. administration for two h, oral glucose tolerance test plus glutathione i.v. administration.
  2. 02HumanNon-randomized trialEfficacy outcome

    In diabetic patients, glutathione alone significantly decreased circulating ICAM-1 levels.

    In plain wordsIn diabetic patients, glutathione alone reduced circulating ICAM-1 levels from baseline.

    Peptide
    Glutathione
    Outcome
    DecreaseCirculating ICAM-1 in diabetic patients
    Study

    n = 9

    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intravenous · two hAs given in this study (human).

    Source sentences

    Summary
    Glutathione administered alone significantly decreased circulating ICAM-1 plasma levels in diabetic patients, while no effect was observed in the normal subjects.
    1 context sentence
    Summary · context
    In this study, three different experiments were performed in nine NIDDM patients and in seven matched healthy controls: oral glucose tolerance test, antioxidant glutathione i.v. administration for two h, oral glucose tolerance test plus glutathione i.v. administration.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy subjects, glutathione alone did not affect circulating ICAM-1 levels.

    In plain wordsIn healthy subjects, glutathione alone did not change circulating ICAM-1 levels from baseline.

    Peptide
    Glutathione
    Outcome
    No significant changeCirculating ICAM-1 in healthy subjects
    Study

    n = 7

    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intravenous · two hAs given in this study (human).

    Source sentences

    Summary
    Glutathione administered alone significantly decreased circulating ICAM-1 plasma levels in diabetic patients, while no effect was observed in the normal subjects.
    1 context sentence
    Summary · context
    In this study, three different experiments were performed in nine NIDDM patients and in seven matched healthy controls: oral glucose tolerance test, antioxidant glutathione i.v. administration for two h, oral glucose tolerance test plus glutathione i.v. administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.