Effects of triptorelin versus placebo on the symptoms of endometriosis.

Bergqvist A, Bergh T, Hogström L, Mattsson S, Nordenskjöld F, Rasmussen C

Fertility and sterility1 Apr 1998Cited by 60 (Europe PMC)

PMID9548161DOI10.1016/s0015-0282(98)00019-3PepBankPUB-09548161

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, triptorelin reduced pain on the Duration Intensity Behavior Scale more than placebo after 2 months.
In plain wordsIn women with endometriosis, triptorelin reduced pain on this scale more than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDuration Intensity Behavior Scale pain
Study
n = 49
Comparator
Placebo
Analysis
Primary
Outcome group
Pain · Reproductive and sexual health
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
Pain symptoms according to both scales were significantly more reduced after 2 months of triptorelin treatment compared to placebo.
4 context sentences(design, population, supporting numbers)
Summary · context
Clinical evaluation, including the Duration Intensity Behavior Scale and Visual Analogue Scale for pain, was performed before the injections and up to 12 months after treatment.
Summary · context
A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up.
Summary · context
Forty-nine women with symptoms of laparoscopically verified endometriosis.
Summary · context
Triptorelin depot or placebo was given every 4 weeks.
Report a problemFND-0954816101
02HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, triptorelin reduced Visual Analogue Scale pain more than placebo after 2 months.
In plain wordsIn women with endometriosis, triptorelin reduced visual scale pain more than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseVisual Analogue Scale pain
Study
n = 49
Comparator
Placebo
Analysis
Primary
Outcome group
Pain · Reproductive and sexual health
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Source sentences
Summary
Pain symptoms according to both scales were significantly more reduced after 2 months of triptorelin treatment compared to placebo.
4 context sentences(design, population, supporting numbers)
Summary · context
Clinical evaluation, including the Duration Intensity Behavior Scale and Visual Analogue Scale for pain, was performed before the injections and up to 12 months after treatment.
Summary · context
A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up.
Summary · context
Forty-nine women with symptoms of laparoscopically verified endometriosis.
Summary · context
Triptorelin depot or placebo was given every 4 weeks.
Report a problemFND-0954816102
03HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, lesion extent decreased 50% with triptorelin and increased 17% with placebo.
In plain wordsIn women with endometriosis, lesion extent decreased with triptorelin and increased with placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseExtent of endometriotic lesions
Study
n = 49
Comparator
Placebo
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Measurements
Lesion extent reduction
50%
triptorelin
Lesion extent increase
17%
placebo
Source sentences
Summary
The extent of endometriotic lesions was reduced 50% during triptorelin treatment and increased 17% during placebo.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up.
Summary · context
Forty-nine women with symptoms of laparoscopically verified endometriosis.
Summary · context
Triptorelin depot or placebo was given every 4 weeks.
Report a problemFND-0954816103
04HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, lesion area decreased 45% with triptorelin and remained unchanged with placebo.
In plain wordsIn women with endometriosis, lesion area decreased with triptorelin and remained unchanged with placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseArea of endometriotic lesions
Study
n = 49
Comparator
Placebo
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Measurements
Lesion area reduction
45%
triptorelin
Source sentences
Summary
The average area of endometriotic lesions was reduced 45% during triptorelin treatment but was unchanged during placebo.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up.
Summary · context
Forty-nine women with symptoms of laparoscopically verified endometriosis.
Summary · context
Triptorelin depot or placebo was given every 4 weeks.
Report a problemFND-0954816104
05HumanRandomized controlled trialSafety outcome
In women with endometriosis, side effects, mainly hot flushes, occurred in 80% with triptorelin versus 33% with placebo.
In plain wordsIn women with endometriosis, side effects, mainly hot flushes, occurred more often with triptorelin than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseSide effects, mainly hot flushes
Study
n = 49
Comparator
Placebo
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated · 6 monthsAs given in this study (human).
Measurements
Side effects
80%
triptorelin
Side effects
33%
placebo
Source sentences
Summary
Side effects, mainly hot flushes, were experienced by 80% of the actively treated group but also by 33% of patients in the placebo group.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, randomized, double-blind study of 6 months of treatment followed by 12 months of follow-up.
Summary · context
Forty-nine women with symptoms of laparoscopically verified endometriosis.
Summary · context
Triptorelin depot or placebo was given every 4 weeks.
Report a problemFND-0954816105

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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