Evidence that gonadotropin-releasing hormone stimulates gene expression and levels of active nitric oxide synthase type I in pituitary gonadotrophs, a process altered by desensitization and, indirectly, by gonadal steroids.

Garrel G, Lerrant Y, Siriostis C, Bérault A, Magre S, Bouchaud C, Counis R

Endocrinology1 Apr 1998Cited by 45 (Europe PMC)

PMID9529006DOI10.1210/endo.139.4.5890PepBankPUB-09529006

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In intact rats, triptorelin increased pituitary NOS I protein, with a rapid rise after an initial lag.
In plain wordsIn rats, triptorelin increased pituitary NOS I protein after an initial delay.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePituitary NOS I protein increase
Study
ratn: not reported in source
intact rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Measurements
NOS I increase
2 fold
8 h
Maximal NOS I increase
4.5 fold
48 h
Source sentences
Summary
A time-course study with a long-lasting formulation showed that rise in NOS I developed rapidly after a lag of approximately 5 h, with a 2-fold increase detectable after 8 h and a maximal 4.5-fold after 48 h.
1 context sentence(design, population, supporting numbers)
Summary · context
In marked contrast, administration of a potent GnRH agonist (Triptorelin) to intact rats increased the levels of NOS I.
Report a problemFND-0952900601
02AnimalAnimal study (in vivo)Mechanism
In intact rats given triptorelin, NOS I protein declined after its peak, with a delayed profile relative to gonadotropin release.
In plain wordsIn rats given triptorelin, NOS I protein declined after its peak, later than gonadotropin release.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLater NOS I protein decline
Study
ratn: not reported in source
intact rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
The level declined afterwards in a manner consistent with homologous desensitization that may occur in the continuous presence of GnRH; however, the profile was different and delayed compared with those of gonadotropin release.
1 context sentence(design, population, supporting numbers)
Summary · context
In marked contrast, administration of a potent GnRH agonist (Triptorelin) to intact rats increased the levels of NOS I.
Report a problemFND-0952900602
03AnimalAnimal study (in vivo)Mechanism
In rats, GnRH agonist triptorelin increased NOS I messenger RNA.
In plain wordsIn rats, triptorelin increased NOS I genetic messages.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseNOS I mRNA
Study
ratn: not reported in source
intact rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
As observed for NOS I protein, NOS I messenger RNA concentration was increased by castration or GnRH agonist and reduced by steroids or GnRH antagonist.
1 context sentence(design, population, supporting numbers)
Summary · context
In marked contrast, administration of a potent GnRH agonist (Triptorelin) to intact rats increased the levels of NOS I.
Report a problemFND-0952900603
04AnimalAnimal study (in vivo)Mechanism
In rats, treatments increasing NOS I concentration also increased activity in gonadotrophs, including the triptorelin exposure.
In plain wordsIn rats, treatments including triptorelin changed NOS I activity with its concentration in gonadotrophs.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseNOS I activity in gonadotrophs
Study
ratn: not reported in source
intact rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
NADPH-diaphorase histochemistry coupled to immuno-identification of the cells revealed that the treatments affecting the concentration of NOS I concomitantly altered the activity but exclusively in gonadotrophs and not in folliculo-stellate cells (which do not respond to GnRH), reinforcing the idea…
1 context sentence(design, population, supporting numbers)
Summary · context
In marked contrast, administration of a potent GnRH agonist (Triptorelin) to intact rats increased the levels of NOS I.
Report a problemFND-0952900604
05AnimalAnimal study (in vivo)Mechanism
In rats, treatments affecting NOS I concentration did not alter activity in folliculo-stellate cells.
In plain wordsIn rats, treatments including triptorelin did not change NOS I activity in folliculo-stellate cells.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeNOS I activity in folliculo-stellate cells
Study
ratn: not reported in source
intact rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
NADPH-diaphorase histochemistry coupled to immuno-identification of the cells revealed that the treatments affecting the concentration of NOS I concomitantly altered the activity but exclusively in gonadotrophs and not in folliculo-stellate cells (which do not respond to GnRH), reinforcing the idea…
1 context sentence(design, population, supporting numbers)
Summary · context
In marked contrast, administration of a potent GnRH agonist (Triptorelin) to intact rats increased the levels of NOS I.
Report a problemFND-0952900605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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