In patients with localized rectal cancer, glucagon doubled tumor protein synthesis to 2.25+/-0.49 %/hr versus 1.16+/-0.30 basal (p < 0.05).
In plain wordsIn patients with localized rectal cancer, glucagon doubled the tumor's protein production rate compared with baseline.
- Peptide
- Glucagon
- Outcome
- IncreaseTumor fractional protein synthetic rate
- Study
n: not reported in source
- Comparator
- Baseline
- Outcome group
- Tumor protein synthesis · Cancer
- Studied dose
- 3 ng/kg/min · infusion · 4 hoursAs given in this study (human).
Measurements
- Tumor fractional protein synthetic rate
- 2.25 %/hr
- glucagon 3 ng/kg/min infusion; +/- 0.49
- Tumor fractional protein synthetic rate
- 1.16 %/hr
- basal; +/- 0.30
Source sentences
In patients with localized rectal cancer, glucagon caused the tumor fractional protein synthetic rate to double (2.25+/-0.49 %/hr, p < 0.05 vs. 1.16+/-0.30 basal).
2 context sentences(design, population, supporting numbers)
The purpose of this study was to determine the effect of glucagon or placebo on the rate of tumor fractional protein synthesis in situ in patients with localized rectal cancer who were not malnourished, demonstrated normal glucagon concentrations, and could therefore be used as a model to study the glucagon effect.
Because GC/IRMS requires only a small sample volume, three consecutive endoscopic biopsies could be obtained from the same tumor to determine isotopic enrichments at baseline, after a 4-hour glucagon infusion (3 ng/kg/min), or after placebo.