Growth hormone responses to growth hormone-releasing hormone and hexarelin in fed and fasted dogs: effect of somatostatin infusion or pretreatment with pirenzepine.

Rigamonti AE, Marazzi N, Cella SG, Cattaneo L, Müller EE

The Journal of endocrinology1 Feb 1998Cited by 7 (Europe PMC)

PMID9518881DOI10.1677/joe.0.1560341PepBankPUB-09518881

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In beagle dogs, hexarelin only slightly increased GH secretion in fasted dogs over that in fed dogs.
In plain wordsIn dogs, hexarelin raised growth hormone only a little more after fasting than when the dogs were fed.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin in fasted versus fed dogs
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
Fed dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
250 micrograms/kg · intravenousAs given in this study (dog).
Source sentences
Summary
In contrast, HEXA, although very effective in causing the release of GH, only slightly increased GH secretion in fasted dogs over that which it induced in fed dogs.
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
Report a problemFND-0951888101

Studies that did not test the peptide alone6

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

02AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement
In beagle dogs, co-administration of GHRH plus hexarelin induced a synergic GH response in fed dogs that increased further with fasting.
In plain wordsIn dogs, GHRH given with hexarelin gave a strong growth hormone rise that grew larger with fasting.
Peptide
Hexarelin
Outcome
IncreaseGH response to GHRH plus hexarelin in fed and fasted dogs
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
Fed dogs
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Co-administration of GHRH plus HEXA into fed dogs induced a synergic GH response that further increased with fasting.
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0951888102
03AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement
In beagle dogs, the lower somatostatin dose failed to counter the GH response to hexarelin, in fed and fasted states.
In plain wordsIn dogs, a low dose of somatostatin did not block the growth hormone rise from hexarelin.
Peptide
Hexarelin
Outcome
No significant changeLow dose somatostatin effect on GH response to hexarelin
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
Saline infusion
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Infusion of the lower dose of SS failed to counter the action of HEXA, either before or during fasting
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0951888103
04AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement
In beagle dogs, the higher somatostatin dose partially reduced the GH response to hexarelin in fed and fasted states.
In plain wordsIn dogs, a higher dose of somatostatin partly reduced the growth hormone rise from hexarelin.
Peptide
Hexarelin
Outcome
DecreaseHigh dose somatostatin effect on GH response to hexarelin
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
Saline infusion
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
whilst the higher SS dose partially reduced it in both conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0951888104
05AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement
In beagle dogs, pirenzepine reduced the GH-releasing effect of hexarelin in the fed state and to a lesser extent during fasting.
In plain wordsIn dogs, pirenzepine reduced the growth hormone rise from hexarelin, less so during fasting.
Peptide
Hexarelin
Outcome
DecreasePirenzepine effect on GH response to hexarelin
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
No pirenzepine
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
In contrast to SS, PZ reduced the GH-releasing effect of GHRH and HEXA, both in the fed state and, though to a lesser extent, during fasting.
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0951888105
06AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement
In fed beagle dogs, pirenzepine only slightly reduced the robust GH rise elicited by GHRH plus hexarelin.
In plain wordsIn fed dogs, pirenzepine only slightly lowered the large growth hormone rise from GHRH plus hexarelin.
Peptide
Hexarelin
Outcome
DecreasePirenzepine effect on GH response to GHRH plus hexarelin in fed dogs
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
No pirenzepine
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Pirenzepine only slightly reduced the robust GH rise elicited by GHRH plus HEXA in fed dogs.
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0951888106
07AnimalNot a test of Hexarelin aloneAnimal study (in vivo)Activity measurement
In fasted beagle dogs, the suppressive effect of pirenzepine on the GH response to GHRH plus hexarelin was lowest.
In plain wordsIn fasted dogs, pirenzepine had its smallest effect on the growth hormone rise from GHRH plus hexarelin.
Peptide
Hexarelin
Outcome
DecreasePirenzepine effect on GH response to GHRH plus hexarelin in fasted dogs
Study
dogn: not reported in source
Young beagle dogs, fed and fasted
Comparator
No pirenzepine
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
The suppressive effect of PZ on the GH response to combined administration of the peptides was lowest in fasted dogs.
1 context sentence(design, population, supporting numbers)
Summary · context
Using unanesthetized young male and female beagle dogs, before and after a 2-day fast
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0951888107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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