Treatment of men with paraphilia with a long-acting analogue of gonadotropin-releasing hormone.

Rösler A, Witztum E

The New England journal of medicine1 Feb 1998Cited by 84 (Europe PMC)

PMID9459644DOI10.1056/nejm199802123380702PepBankPUB-09459644

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome
In men with severe paraphilia, triptorelin with supportive psychotherapy reduced deviant sexual fantasies and desires compared with before therapy.
In plain wordsIn men with severe paraphilia, triptorelin with psychotherapy reduced deviant sexual fantasies and desires compared with before treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDeviant sexual fantasies and desires
Study
n = 30
Comparator
Before therapy
Outcome group
Sexual function · Reproductive and sexual health
Measurements
Fantasies and desires
48 per week
before therapy
Fantasies and desires
0 per week
during therapy
Source sentences
Summary
All the men had a decrease in the number of deviant sexual fantasies and desires, from a mean (+/-SD) of 48+/-10 per week before therapy to zero during therapy (P<0.001), and a decrease in the number of incidents of abnormal sexual behavior (from 5+/-2 per month to zero, P<0.001) while receiving triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964401
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome
In men with severe paraphilia, triptorelin with supportive psychotherapy reduced abnormal sexual behavior compared with before therapy.
In plain wordsIn men with severe paraphilia, triptorelin with psychotherapy reduced abnormal sexual behavior compared with before treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseAbnormal sexual behavior
Study
n = 30
Comparator
Before therapy
Outcome group
Sexual function · Reproductive and sexual health
Measurements
Abnormal sexual behavior
5 incidents per month
before therapy
Abnormal sexual behavior
0 incidents per month
during therapy
Source sentences
Summary
All the men had a decrease in the number of deviant sexual fantasies and desires, from a mean (+/-SD) of 48+/-10 per week before therapy to zero during therapy (P<0.001), and a decrease in the number of incidents of abnormal sexual behavior (from 5+/-2 per month to zero, P<0.001) while receiving triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964402
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studySafety outcome
In men with severe paraphilia, erectile failure was a main side effect during triptorelin with supportive psychotherapy.
In plain wordsIn men with severe paraphilia, erectile failure occurred during triptorelin with psychotherapy.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableErectile failure
Study
n = 30
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
The main side effects were erectile failure, hot flashes, and decrease in bone mineral density in some men.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964405
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studySafety outcome
In men with severe paraphilia, hot flashes were a main side effect during triptorelin with supportive psychotherapy.
In plain wordsIn men with severe paraphilia, hot flashes occurred during triptorelin with psychotherapy.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableHot flashes
Study
n = 30
Outcome group
Adverse events · Whole body
Source sentences
Summary
The main side effects were erectile failure, hot flashes, and decrease in bone mineral density in some men.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964406
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome
In men with paraphilia continuing triptorelin and psychotherapy for at least one year, behavioral effects persisted in all continuing participants.
In plain wordsIn men with paraphilia continuing triptorelin and psychotherapy for at least one year, behavioral effects persisted in all continuing participants.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicablePersistence of behavioral effects
Study
n = 24
Outcome group
Sexual function · Reproductive and sexual health
Source sentences
Summary
These effects were evident after 3 to 10 months of therapy (P<0.001) and persisted in all 24 men who continued therapy for at least 1 year.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964403
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyEfficacy outcome
In men with severe paraphilia, serum testosterone decreased during triptorelin with supportive psychotherapy compared with before therapy.
In plain wordsIn men with severe paraphilia, testosterone decreased during triptorelin with psychotherapy compared with before treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum testosterone
Study
n: not reported in source
Comparator
Before therapy
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Testosterone
545 ng/dL
before therapy
Testosterone
23 ng/dL
after 42 months
Source sentences
Summary
The men's mean serum testosterone concentration fell from 545+/-196 ng per deciliter (18.9+/-6.8 nmol per liter) before therapy to 23+/-14 ng per deciliter (0.8+/-0.5 nmol per liter, P<0.001) after 42 months of triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964404
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studySafety outcome
In some men with severe paraphilia, bone mineral density decreased during triptorelin with supportive psychotherapy.
In plain wordsIn some men with severe paraphilia, bone density decreased during triptorelin with psychotherapy.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseBone mineral density
Study
n: not reported in source
Comparator
Before therapy
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The main side effects were erectile failure, hot flashes, and decrease in bone mineral density in some men.
1 context sentence(design, population, supporting numbers)
Summary · context
In an uncontrolled observational study, we treated 30 men (mean age, 32 years) with severe long-standing paraphilia (25 with pedophilia and 5 with other types of abnormal behavior) with monthly injections of 3.75 mg of triptorelin and supportive psychotherapy for 8 to 42 months.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945964407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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