Precocious puberty in children with myelomeningocele: treatment with gonadotropin-releasing hormone analogues.

Trollmann R, Strehl E, Dörr HG

Developmental medicine and child neurology1 Jan 1998Cited by 17 (Europe PMC)

PMID9459215DOI10.1111/j.1469-8749.1998.tb15354.xPepBankPUB-09459215

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele and precocious puberty, pooled triptorelin or leuprorelin treatment decreased gonadotropins without complete prepubertal suppression.
In plain wordsIn children with myelomeningocele, pooled triptorelin or leuprorelin treatment lowered gonadotropins without fully reaching prepubertal levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum gonadotropins
Study
n = 8
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Elevated gonadotropin serum levels and sex steroid levels decreased during treatment, although no complete suppression to prepubertal levels was reached.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921501
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele and precocious puberty, pooled triptorelin or leuprorelin treatment decreased sex steroids without complete prepubertal suppression.
In plain wordsIn children with myelomeningocele, pooled triptorelin or leuprorelin treatment lowered sex steroids without fully reaching prepubertal levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSex steroid levels
Study
n = 8
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Elevated gonadotropin serum levels and sex steroid levels decreased during treatment, although no complete suppression to prepubertal levels was reached.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921502
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele and precocious puberty, pubertal progression stopped during pooled triptorelin or leuprorelin treatment.
In plain wordsIn children with myelomeningocele, puberty stopped progressing during pooled triptorelin or leuprorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePubertal progression
Study
n = 8
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Progression of pubertal development and menses stopped in all patients.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921503
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele, pooled triptorelin or leuprorelin treatment reduced the tempo of bone age acceleration.
In plain wordsIn children with myelomeningocele, pooled triptorelin or leuprorelin treatment slowed bone age acceleration.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseBone age acceleration
Study
n = 8
Outcome group
Linear growth · Endocrine and hormones
Source sentences
Summary
The tempo of BA acceleration (deltaBA:deltaCA) decreased, but no significant improvement in height standard deviation score BA and predicted adult height resulted.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921505
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele, height SDS for bone age did not improve significantly during pooled triptorelin or leuprorelin treatment.
In plain wordsIn children with myelomeningocele, pooled triptorelin or leuprorelin treatment did not significantly improve height scores for bone age.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeHeight SDS for bone age
Study
n = 8
Outcome group
Linear growth · Endocrine and hormones
Source sentences
Summary
The tempo of BA acceleration (deltaBA:deltaCA) decreased, but no significant improvement in height standard deviation score BA and predicted adult height resulted.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921506
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele, predicted adult height did not improve significantly during pooled triptorelin or leuprorelin treatment.
In plain wordsIn children with myelomeningocele, pooled triptorelin or leuprorelin treatment did not significantly improve predicted adult height.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePredicted adult height
Study
n = 8
Outcome group
Linear growth · Endocrine and hormones
Source sentences
Summary
The tempo of BA acceleration (deltaBA:deltaCA) decreased, but no significant improvement in height standard deviation score BA and predicted adult height resulted.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921507
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesSafety outcome
In children with myelomeningocele, no side effects were observed during pooled triptorelin or leuprorelin treatment.
In plain wordsIn children with myelomeningocele, no side effects occurred during pooled triptorelin or leuprorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableSide effects
Study
n = 8
Outcome group
Adverse events · Whole body
Source sentences
Summary
No side effects during treatment were observed.
2 context sentences(design, population, supporting numbers)
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921508
08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneCase report or seriesEfficacy outcome
In children with myelomeningocele and precocious puberty, menses stopped during pooled triptorelin or leuprorelin treatment.
In plain wordsIn children with myelomeningocele, menstruation stopped during pooled triptorelin or leuprorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMenses
Study
n = 2
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Progression of pubertal development and menses stopped in all patients.
3 context sentences(design, population, supporting numbers)
Summary · context
Bone age (BA) was accelerated in all cases prior to treatment and two girls were already menstruating.
Summary · context
We report on eight patients (six female, two male) with MMC, hydrocephalus, and CPP who were treated with GnRH analogues: triptorelin intramuscularly (N=5) or leuprorelin subcutaneously (N=3).
Summary · context
Auxological data and hormone levels were assessed before treatment and every 6 months during treatment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0945921504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:37 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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