Evidence of a local mechanism for desmopressin-induced tissue-type plasminogen activator release in human forearm.

Wall U, Jern S, Tengborn L, Jern C

Blood1 Jan 1998Cited by 29 (Europe PMC)

PMID9427706DOI10.1182/blood.v91.2.529PepBankPUB-09427706

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

01HumanNon-randomized trialMechanism
In healthy men, stepwise DDAVP increased t-PA release, peaking after 15 minutes at the highest dose (P < .0001).
In plain wordsIn healthy men, desmopressin increased local t-PA release compared with baseline.
Peptide
Desmopressin
Outcome
IncreaseStepwise t-PA release
Study
n = 7
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
0.7, 7.0, and 70 ng/min · intrabrachial arteryAs given in this study (human).
Measurements
P value
< 0.0001 none
t-PA release, stepwise DDAVP infusion, ANOVA
Time to peak t-PA release
15 minutes
highest dose-step
Source sentences
Summary
Stepwise infusion of DDAVP induced a massive regulated release of t-PA with a peak after 15 minutes on the highest dose-step (ANOVA; P < .0001).
2 context sentences(design, population, supporting numbers)
Summary · context
In a first study (n = 7), DDAVP and placebo were administered as randomized single-blind stepwise intrabrachial artery infusions (0.7, 7.0, and 70 ng/min).
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770601
02HumanNon-randomized trialMechanism
In healthy men receiving stepwise DDAVP, average maximum t-PA release was 178 ng/min.
In plain wordsIn healthy men receiving desmopressin, average maximum t-PA release was 178 ng/min.
Peptide
Desmopressin
Outcome
Not applicableMaximum t-PA release rate
Study
n = 7
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
0.7, 7.0, and 70 ng/min · intrabrachial arteryAs given in this study (human).
Measurements
Average maximum net t-PA release rate
178 ng/min
stepwise DDAVP infusion
Source sentences
Summary
The average maximum net release rate was 178 ng/min, and the total amount of t-PA released was, on the average, 3,000 ng.
3 context sentences(design, population, supporting numbers)
Summary · context
Stepwise infusion of DDAVP induced a massive regulated release of t-PA with a peak after 15 minutes on the highest dose-step (ANOVA; P < .0001).
Summary · context
In a first study (n = 7), DDAVP and placebo were administered as randomized single-blind stepwise intrabrachial artery infusions (0.7, 7.0, and 70 ng/min).
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770602
03HumanNon-randomized trialMechanism
In healthy men receiving stepwise DDAVP, average total t-PA release was 3,000 ng.
In plain wordsIn healthy men receiving desmopressin, average total t-PA release was 3,000 ng.
Peptide
Desmopressin
Outcome
Not applicableTotal t-PA release
Study
n = 7
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
0.7, 7.0, and 70 ng/min · intrabrachial arteryAs given in this study (human).
Measurements
Average total t-PA released
3000 ng
stepwise DDAVP infusion
Source sentences
Summary
The average maximum net release rate was 178 ng/min, and the total amount of t-PA released was, on the average, 3,000 ng.
3 context sentences(design, population, supporting numbers)
Summary · context
Stepwise infusion of DDAVP induced a massive regulated release of t-PA with a peak after 15 minutes on the highest dose-step (ANOVA; P < .0001).
Summary · context
In a first study (n = 7), DDAVP and placebo were administered as randomized single-blind stepwise intrabrachial artery infusions (0.7, 7.0, and 70 ng/min).
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770603
04HumanNon-randomized trialMechanism
In healthy men receiving stepwise DDAVP, most released t-PA was active.
In plain wordsIn healthy men receiving desmopressin, most released t-PA was active.
Peptide
Desmopressin
Outcome
Not applicableActive t-PA fraction
Study
n = 7
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
0.7, 7.0, and 70 ng/min · intrabrachial arteryAs given in this study (human).
Source sentences
Summary
The majority was released in its active form.
3 context sentences(design, population, supporting numbers)
Summary · context
Stepwise infusion of DDAVP induced a massive regulated release of t-PA with a peak after 15 minutes on the highest dose-step (ANOVA; P < .0001).
Summary · context
In a first study (n = 7), DDAVP and placebo were administered as randomized single-blind stepwise intrabrachial artery infusions (0.7, 7.0, and 70 ng/min).
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770604
05HumanNon-randomized trialMechanism
In healthy men, stepwise DDAVP did not stimulate local vWF release.
In plain wordsIn healthy men, stepwise desmopressin did not stimulate local vWF release.
Peptide
Desmopressin
Outcome
No significant changeLocal vWF release with stepwise infusion
Study
n = 7
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
0.7, 7.0, and 70 ng/min · intrabrachial arteryAs given in this study (human).
Source sentences
Summary
In contrast, DDAVP did not stimulate a local release of vWF in either study.
2 context sentences(design, population, supporting numbers)
Summary · context
In a first study (n = 7), DDAVP and placebo were administered as randomized single-blind stepwise intrabrachial artery infusions (0.7, 7.0, and 70 ng/min).
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770606
06HumanNon-randomized trialMechanism
In healthy men, constant-rate DDAVP increased t-PA release in the infused arm but not the control arm.
In plain wordsIn healthy men, desmopressin increased t-PA release in the infused arm compared with the control arm.
Peptide
Desmopressin
Outcome
IncreaseConstant-rate local t-PA release
Study
n = 4
Comparator
Control arm
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
70 ng/min · intrabrachial artery · 20 minutesAs given in this study (human).
Source sentences
Summary
Constant-rate DDAVP infusion again markedly increased t-PA release in the infusion arm but had no effect whatsoever in the control arm.
2 context sentences(design, population, supporting numbers)
Summary · context
In a another subset of subjects (n = 4), a constant-rate DDAVP infusion of 70 ng/min was administered for 20 minutes in the brachial artery of the nondominant arm with the dominant arm as control.
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770605
07HumanNon-randomized trialMechanism
In healthy men, constant-rate DDAVP did not stimulate local vWF release.
In plain wordsIn healthy men, constant-rate desmopressin did not stimulate local vWF release.
Peptide
Desmopressin
Outcome
No significant changeLocal vWF release with constant infusion
Study
n = 4
Outcome group
Bleeding and clotting · Cardiovascular
Studied dose
70 ng/min · intrabrachial artery · 20 minutesAs given in this study (human).
Source sentences
Summary
In contrast, DDAVP did not stimulate a local release of vWF in either study.
2 context sentences(design, population, supporting numbers)
Summary · context
In a another subset of subjects (n = 4), a constant-rate DDAVP infusion of 70 ng/min was administered for 20 minutes in the brachial artery of the nondominant arm with the dominant arm as control.
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770607
08HumanNon-randomized trialMechanism
In healthy men, central hemodynamics did not change during DDAVP infusions.
In plain wordsIn healthy men, central circulation measures did not change during desmopressin infusions.
Peptide
Desmopressin
Outcome
No significant changeCentral hemodynamics
Study
n: not reported in source
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · intrabrachial arteryAs given in this study (human).
Source sentences
Summary
Central hemodynamics were unchanged during infusions despite a local vasodilatory response with DDAVP.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770608
09HumanNon-randomized trialMechanism
In healthy men, DDAVP caused a local vasodilatory response.
In plain wordsIn healthy men, desmopressin widened local blood vessels.
Peptide
Desmopressin
Outcome
IncreaseLocal vasodilation
Study
n: not reported in source
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · intrabrachial arteryAs given in this study (human).
Source sentences
Summary
Central hemodynamics were unchanged during infusions despite a local vasodilatory response with DDAVP.
1 context sentence(design, population, supporting numbers)
Summary · context
Healthy, young, nonsmoking male volunteers were studied.
Report a problemFND-0942770609

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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