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Study · In vitro (cells) · 1997

3 results

Alpha-melanocyte-stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation.

Scott G, Cassidy L, Abdel-Malek Z

Experimental cell research1 Nov 1997Cited by 26 (Europe PMC)

PMID9417862 (opens in a new tab)DOI10.1006/excr.1997.3765 (opens in a new tab)PepBankPUB-09417862
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In treated human melanocytes, NDP-MSH induced reorganization of the actin stress fiber cytoskeleton.

    In plain wordsIn human pigment cells in the lab, NDP-MSH changed the arrangement of the cell's internal actin fibres.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableActin stress fiber cytoskeleton reorganization
    Study

    humann: not reported in source

    normal human melanocytes
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the potent alpha-MSH analog (Nle4, D-Phe7)-alpha-MSH (NDP-MSH) induces reorganization of the actin stress fiber cytoskeleton in treated human melanocytes
  2. 02LabIn vitro (cells)Mechanism

    In human melanocytes, NDP-MSH was associated with increased adhesion to fibronectin.

    In plain wordsIn human pigment cells in the lab, NDP-MSH was linked to stronger sticking to fibronectin.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMelanocyte adhesion to fibronectin
    Study

    humann: not reported in source

    normal human melanocytes
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    the potent alpha-MSH analog (Nle4, D-Phe7)-alpha-MSH (NDP-MSH) induces reorganization of the actin stress fiber cytoskeleton in treated human melanocytes and that this reorganization is associated with increased adhesion to fibronectin (FN).
  3. 03LabIn vitro (cells)Mechanism

    In human melanocytes, NDP-MSH did not induce tyrosine phosphorylation of focal adhesion kinase pp125FAK, whereas endothelin-1 did.

    In plain wordsIn human pigment cells in the lab, NDP-MSH did not trigger phosphorylation of focal adhesion kinase, unlike endothelin-1.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changepp125FAK tyrosine phosphorylation
    Study

    humann: not reported in source

    normal human melanocytes
    Comparator
    Endothelin-1
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, we show that focal adhesion kinase (pp125FAK), a nonreceptor tyrosine kinase associated with focal contact formation and cell migration, is phosphorylated on tyrosine residues after treatment of melanocytes with ET-1, but not NDP-MSH.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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