Low hexarelin dose and pyridostigmine have additive effect and potentiate to the same extent the GHRH-induced GH response in man.

Arvat E, Di Vito L, Ramunni J, Gianotti L, Giordano R, Deghenghi R, Camanni F, Ghigo E

Clinical endocrinology1 Oct 1997Cited by 7 (Europe PMC)

PMID9404449DOI10.1046/j.1365-2265.1997.3081114.xPepBankPUB-09404449

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialActivity measurement
In men, the GH response to hexarelin was dose-dependent across 0.25, 0.5 and 2.0 micrograms/kg.
In plain wordsIn men, higher hexarelin doses released more growth hormone.
Peptide
Hexarelin
Outcome
IncreaseDose dependence of GH response to hexarelin
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.25, 0.5 and 2.0 micrograms/kg · intravenousAs given in this study (human).
Source sentences
Summary
The GH response to HEX administration was dose-dependent. In fact, the GH response to 0.25 microgram/kg HEX (AUC, mean +/- SEM: 816.4 (235.6 mU/l/120 min) was lower, although not significantly, than that to 0.5 microgram/kg HEX (2154.6 +/- 491.6 mU/l/120 min), which, in turn, was lower (p < 0.05) th…
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444901
02HumanRandomized controlled trialActivity measurement
In men, hexarelin 0.25 micrograms/kg produced a GH response.
In plain wordsIn men, the lowest hexarelin dose released some growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH AUC after hexarelin 0.25 micrograms/kg
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH AUC
816.4 mU/l/120 min
0.25 microgram/kg
Source sentences
Summary
the GH response to 0.25 microgram/kg HEX (AUC, mean +/- SEM: 816.4 (235.6 mU/l/120 min)
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444902
03HumanRandomized controlled trialActivity measurement
In men, hexarelin 0.5 micrograms/kg produced a GH response.
In plain wordsIn men, the middle hexarelin dose released growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH AUC after hexarelin 0.5 micrograms/kg
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.5 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH AUC
2154.6 mU/l/120 min
0.5 microgram/kg
Source sentences
Summary
than that to 0.5 microgram/kg HEX (2154.6 +/- 491.6 mU/l/120 min)
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444903
04HumanRandomized controlled trialActivity measurement
In men, hexarelin 2.0 micrograms/kg produced a GH response that was higher than the 0.5 micrograms/kg response.
In plain wordsIn men, the highest hexarelin dose released the most growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH AUC after hexarelin 2.0 micrograms/kg
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH AUC
4819.2 mU/l/120 min
2.0 micrograms/kg
Source sentences
Summary
than that after 2.0 micrograms/kg HEX (4819.2 +/- 668.0 mU/l/120 min)
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444904
05HumanRandomized controlled trialActivity measurement
In men, the GH rise after GHRH was lower than after hexarelin 2.0 micrograms/kg.
In plain wordsIn men, the top hexarelin dose released more growth hormone than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH response, hexarelin 2.0 micrograms/kg vs GHRH
Study
n = 6
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2.0 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH AUC after GHRH
1299.2 mU/l/120 min
GHRH 1.0 microgram/kg
GH AUC after hexarelin
4819.2 mU/l/120 min
2.0 micrograms/kg
Source sentences
Summary
The GH rise after GHRH (1299.2 +/- 222.8 mU/l/120 min) was lower (P < 0.05) than that after 2.0 micrograms/kg HEX, but not different from the responses to either 0.25 or 0.5 microgram/kg HEX.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444905
06HumanRandomized controlled trialActivity measurement
In men, the GH rise after GHRH did not differ from the responses to hexarelin 0.25 or 0.5 micrograms/kg.
In plain wordsIn men, low and middle hexarelin doses released about as much growth hormone as GHRH.
Peptide
Hexarelin
Outcome
No significant changeGH response, hexarelin 0.25 and 0.5 micrograms/kg vs GHRH
Study
n = 6
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.25 and 0.5 micrograms/kg · intravenousAs given in this study (human).
Source sentences
Summary
The GH rise after GHRH (1299.2 +/- 222.8 mU/l/120 min) was lower (P < 0.05) than that after 2.0 micrograms/kg HEX, but not different from the responses to either 0.25 or 0.5 microgram/kg HEX.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444906
07HumanRandomized controlled trialActivity measurement
In men, hexarelin 0.25 micrograms/kg potentiated the GH response to GHRH.
In plain wordsIn men, the lowest hexarelin dose increased the growth hormone response to GHRH.
Peptide
Hexarelin
Outcome
IncreasePotentiation of GHRH-induced GH response by hexarelin 0.25 micrograms/kg
Study
n = 6
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
0.25 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH AUC, hexarelin 0.25 microgram/kg plus GHRH
5958.8 mU/l/120 min
GHRH 1.0 microgram/kg
Source sentences
Summary
PD pretreatment as well as 0.25 microgram/kg HEX truly potentiated the GH response to GHRH to the same extent (4926.6 +/- 912.8 mU/l/120 min, p < 0.05 and 5958.8 +/- 750.0 mU/l/120 min, p < 0.05 respectively).
3 context sentences(design, population, supporting numbers)
Summary · context
The interactions between the lowest HEX dose or PD and the maximally effective GHRH dose (1.0 microgram/kg i.v.) were also studied.
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
Report a problemFND-0940444911

Studies that did not test the peptide alone5

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

08HumanNot a test of Hexarelin aloneRandomized controlled trialMechanism
In men, pyridostigmine pretreatment enhanced the GH response to hexarelin 0.25 micrograms/kg in an additive way.
In plain wordsIn men, adding pyridostigmine increased the growth hormone response to the lowest hexarelin dose.
Peptide
Hexarelin
Outcome
IncreasePyridostigmine effect on GH response to hexarelin 0.25 micrograms/kg
Study
n = 6
Comparator
Hexarelin 0.25 micrograms/kg alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC with pyridostigmine
1961.4 mU/l/120 min
hexarelin 0.25 microgram/kg
Source sentences
Summary
PD pretreatment enhanced the GH response to the lowest HEX dose (1961.4 +/- 253.8 mU/l/120 min, p < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0940444907
09HumanNot a test of Hexarelin aloneRandomized controlled trialMechanism
In men, pyridostigmine pretreatment did not change the GH response to hexarelin 0.5 micrograms/kg.
In plain wordsIn men, adding pyridostigmine did not change the growth hormone response to the middle hexarelin dose.
Peptide
Hexarelin
Outcome
No significant changePyridostigmine effect on GH response to hexarelin 0.5 micrograms/kg
Study
n = 6
Comparator
Hexarelin 0.5 micrograms/kg alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC with pyridostigmine
2753.6 mU/l/120 min
hexarelin 0.5 microgram/kg
Source sentences
Summary
but failed to modify the GH response to either 0.5 or 2.0 micrograms/kg HEX (2753.6 +/- 444.6 and 5179.0 +/- 770.8 mU/l/120 min, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0940444908
10HumanNot a test of Hexarelin aloneRandomized controlled trialMechanism
In men, pyridostigmine pretreatment did not change the GH response to hexarelin 2.0 micrograms/kg.
In plain wordsIn men, adding pyridostigmine did not change the growth hormone response to the highest hexarelin dose.
Peptide
Hexarelin
Outcome
No significant changePyridostigmine effect on GH response to hexarelin 2.0 micrograms/kg
Study
n = 6
Comparator
Hexarelin 2.0 micrograms/kg alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC with pyridostigmine
5179 mU/l/120 min
hexarelin 2.0 micrograms/kg
Source sentences
Summary
but failed to modify the GH response to either 0.5 or 2.0 micrograms/kg HEX (2753.6 +/- 444.6 and 5179.0 +/- 770.8 mU/l/120 min, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0940444909
11HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement
In men, the GH response to hexarelin 0.25 micrograms/kg plus pyridostigmine was lower than the response to hexarelin 2.0 micrograms/kg alone.
In plain wordsIn men, the lowest hexarelin dose plus pyridostigmine released less growth hormone than the highest hexarelin dose alone.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin 0.25 micrograms/kg plus pyridostigmine vs hexarelin 2.0 micrograms/kg
Study
n = 6
Comparator
Hexarelin 2.0 micrograms/kg alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Notably, the GH response to 0.25 microgram/kg HEX + PD was still lower (P < 0.05) than that to 2.0 micrograms/kg HEX.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0940444910
12HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement
In men, the GH response to hexarelin 0.25 micrograms/kg plus GHRH was similar to that after hexarelin 2.0 micrograms/kg alone.
In plain wordsIn men, the lowest hexarelin dose plus GHRH released about as much growth hormone as the highest hexarelin dose alone.
Peptide
Hexarelin
Outcome
No significant changeGH response to hexarelin 0.25 micrograms/kg plus GHRH vs hexarelin 2.0 micrograms/kg
Study
n = 6
Comparator
Hexarelin 2.0 micrograms/kg alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
and 0.25 microgram/kg HEX + GHRH were similar to that after 2.0 micrograms/kg HEX alone.
2 context sentences(design, population, supporting numbers)
Summary · context
We studied the GH release induced by various HEX doses (0.25, 0.5 and 2.0 micrograms/kg i.v.) and pyridostigmine (PD, 120 mg po), both alone and coadministered.
Summary · context
Six normal male volunteers, aged 24-30 years, were studied.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0940444912

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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