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Study · Animal study (in vivo) · rat · 1997

3 results

BPC 157's effect on healing.

Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, Ljubanovic D, Coric V, Konjevoda P, Petek M, Rucman R, Turkovic B, Perovic D and 8 more

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Mikus D, Jandrijevic S, Medvidovic M, Tadic T, Romac B, Kos J, Peric J, Kolega Z

Journal of physiology, Paris1 May 1997Cited by 39 (Europe PMC)

PMID9403790 (opens in a new tab)DOI10.1016/s0928-4257(97)89480-6 (opens in a new tab)PepBankPUB-09403790
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with skin incisional wounds, BPC‑157-treated animals differed significantly from controls, showing a promoting involvement in healing.

    In plain wordsIn rats with skin cuts, BPC‑157 differed from controls and promoted healing.

    Peptide
    BPC-157
    Outcome
    IncreaseHealing of skin incisional wounds
    Study

    ratn: not reported in source

    skin incisional wound
    Comparator
    Control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · intragastric and local (varied by experiment)As given in this study (rat).

    Source sentences

    Summary
    In all experiments significant differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process.
    2 context sentences
    Summary · context
    The specimens were histologically assessed for collagen, reticulin and blood vessels using scoring and morphometry.
    Summary · context
    In our work we tested the influence of BPC 157 on: granulation tissue and collagen formation, on angiogenesis as well as on tensile strength development, using three experimental rat models: 1) skin incisional wounds; 2) colon-colon anastomoses; and 3) angiogenesis model with synthetic sponge implantation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with colon-colon anastomoses, BPC‑157-treated animals differed significantly from controls, showing a promoting involvement in healing.

    In plain wordsIn rats with joined colon sections, BPC‑157 differed from controls and promoted healing.

    Peptide
    BPC-157
    Outcome
    IncreaseHealing of colon-colon anastomoses
    Study

    ratn: not reported in source

    colon-colon anastomosis
    Comparator
    Control
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    Dose not stated · intragastric and local (varied by experiment)As given in this study (rat).

    Source sentences

    Summary
    In all experiments significant differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process.
    2 context sentences
    Summary · context
    The specimens were histologically assessed for collagen, reticulin and blood vessels using scoring and morphometry.
    Summary · context
    In our work we tested the influence of BPC 157 on: granulation tissue and collagen formation, on angiogenesis as well as on tensile strength development, using three experimental rat models: 1) skin incisional wounds; 2) colon-colon anastomoses; and 3) angiogenesis model with synthetic sponge implantation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In the rat sponge implantation model, BPC‑157-treated animals differed significantly from controls, showing a promoting involvement in healing and angiogenesis.

    In plain wordsIn rats with sponge implants, BPC‑157 differed from controls and promoted healing.

    Peptide
    BPC-157
    Outcome
    IncreaseAngiogenesis with sponge implantation
    Study

    ratn: not reported in source

    synthetic sponge implantation angiogenesis model
    Comparator
    Control
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · intragastric and local (varied by experiment)As given in this study (rat).

    Source sentences

    Summary
    In all experiments significant differences between BPC 157-treated animals and controls were found, showing a strong, promoting involvement of BPC in the healing process.
    2 context sentences
    Summary · context
    The specimens were histologically assessed for collagen, reticulin and blood vessels using scoring and morphometry.
    Summary · context
    In our work we tested the influence of BPC 157 on: granulation tissue and collagen formation, on angiogenesis as well as on tensile strength development, using three experimental rat models: 1) skin incisional wounds; 2) colon-colon anastomoses; and 3) angiogenesis model with synthetic sponge implantation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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