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Study · Animal study (in vivo) · chicken · 1997

2 results

The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks.

Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, Seiwerth S, Sikiric P, Peric J, Geres D, Kos J

Journal of physiology, Paris1 May 1997Cited by 68 (Europe PMC)

PMID9403788 (opens in a new tab)DOI10.1016/s0928-4257(97)89478-8 (opens in a new tab)PepBankPUB-09403788
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In chicks, BPC‑157 did not cause any tissue or organ damage.

    In plain wordsIn chicks, BPC‑157 did not cause tissue or organ damage.

    Peptide
    BPC-157
    Outcome
    No significant changeTissue or organ damage from BPC 157
    Study

    chickenn: not reported in source

    L-NAME and L-arginine induced lesions in broiler chicks
    Comparator
    Saline control
    Outcome group
    Adverse events · Whole body
    Studied dose
    10 µg/kg · intraperitonealAs given in this study (chicken).

    Source sentences

    Summary
    but the latter substance did not cause any tissue or organ damage.
    2 context sentences
    Summary · context
    Acute toxicity, which includes single dose application of saline (1 mL intraperitoneally (i.p.)), BPC 157 (10 micrograms/kg bw), L-NAME (NO antagonist, doses 50, 100, 150 mg/kg bw) and L-arginine (NO agonist/100 mg/kg bw with their combination L-NAME + BPC 157; L-NAME + L-arginine) was investigated.
    Summary · context
    We describe the effects of nitric oxide (NO) agonists and antagonists and the influence of a novel organoprotective pentadecapeptide BPC 157, on the development of pulmonary hypertension syndrome and tissue lesions in chicks.

Studies that did not test the peptide alone1

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 02AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Efficacy outcome

    In chicks given L-NAME, simultaneous L-arginine and BPC‑157 together prevented pulmonary hypertension syndrome.

    In plain wordsIn chicks, L-arginine and BPC‑157 given together prevented L-NAME-induced pulmonary hypertension syndrome.

    Peptide
    BPC-157
    Outcome
    DecreaseL-NAME-induced pulmonary hypertension syndrome
    Study

    chickenn: not reported in source

    L-NAME and L-arginine induced lesions in broiler chicks
    Comparator
    L-NAME alone
    Outcome group
    Cardiovascular events · Cardiovascular

    Source sentences

    Summary
    Application of L-NAME caused pulmonary hypertension syndrome (PHS) in the treated chicks, which was prevented by the simultaneous application of L-arginine and BPC 157.
    1 context sentence
    Summary · context
    We describe the effects of nitric oxide (NO) agonists and antagonists and the influence of a novel organoprotective pentadecapeptide BPC 157, on the development of pulmonary hypertension syndrome and tissue lesions in chicks.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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