The GH-releasing effect of Hexarelin, a synthetic hexapeptide, in newborns is lower than in young adults.

Bartolotta E, Bellone J, Aimaretti G, Arvat E, Benso L, Deghenghi R, Camanni F, Ghigo E

Journal of pediatric endocrinology & metabolism : JPEM1 Sept 1997Cited by 3 (Europe PMC)

PMID9401905DOI10.1515/jpem.1997.10.5.491PepBankPUB-09401905

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialActivity measurement
The GH response to hexarelin was lower in newborns than in young adults.
In plain wordsHexarelin released less growth hormone in newborns than in young adults.
Peptide
Hexarelin
Outcome
DecreaseDelta GH peak after hexarelin, newborns vs young adults
Study
n = 18
Comparator
Young adults
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
Delta GH peak
32.8 micrograms/l
newborns
Delta GH peak
56.2 micrograms/l
young adults
Source sentences
Summary
The mean delta GH peak after HEX in NB (32.8 +/- 4.7 micrograms/l) was similar to that in PC (34.6 +/- 4.3 micrograms/l) and lower (p < 0.01) than that in YA (56.2 +/- 7.4 micrograms/l).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC, 9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2 yr) the GH response to Hexarelin (HEX, 2 micrograms/kg i.v.) compared to that observed after GHRH (1 microgram/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6…
Report a problemFND-0940190502
02HumanNon-randomized trialActivity measurement
The GH response to hexarelin in newborns was similar to that in prepubertal children.
In plain wordsHexarelin released a similar amount of growth hormone in newborns and in prepubertal children.
Peptide
Hexarelin
Outcome
No significant changeDelta GH peak after hexarelin, newborns vs prepubertal children
Study
n = 18
Comparator
Prepubertal children
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
Delta GH peak
32.8 micrograms/l
newborns
Delta GH peak
34.6 micrograms/l
prepubertal children
Source sentences
Summary
The mean delta GH peak after HEX in NB (32.8 +/- 4.7 micrograms/l) was similar to that in PC (34.6 +/- 4.3 micrograms/l) and lower (p < 0.01) than that in YA (56.2 +/- 7.4 micrograms/l).
1 context sentence(design, population, supporting numbers)
Summary · context
We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC, 9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2 yr) the GH response to Hexarelin (HEX, 2 micrograms/kg i.v.) compared to that observed after GHRH (1 microgram/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6…
Report a problemFND-0940190503
03HumanNon-randomized trialActivity measurement
In prepubertal children, the GH response to hexarelin was higher than the response to GHRH.
In plain wordsIn prepubertal children, hexarelin released more growth hormone than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH response, hexarelin vs GHRH in prepubertal children
Study
n = 12
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Source sentences
Summary
while in PC and YA the somatotrope response to HEX was higher (p < 0.03 and 0.0004, respectively) than to GHRH.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC, 9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2 yr) the GH response to Hexarelin (HEX, 2 micrograms/kg i.v.) compared to that observed after GHRH (1 microgram/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6…
Report a problemFND-0940190505
04HumanNon-randomized trialActivity measurement
In young adults, the GH response to hexarelin was higher than the response to GHRH.
In plain wordsIn young adults, hexarelin released more growth hormone than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH response, hexarelin vs GHRH in young adults
Study
n = 12
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Source sentences
Summary
while in PC and YA the somatotrope response to HEX was higher (p < 0.03 and 0.0004, respectively) than to GHRH.
1 context sentence(design, population, supporting numbers)
Summary · context
We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC, 9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2 yr) the GH response to Hexarelin (HEX, 2 micrograms/kg i.v.) compared to that observed after GHRH (1 microgram/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6…
Report a problemFND-0940190506
05HumanNon-randomized trialActivity measurement
In newborns, hexarelin produced a delta GH peak.
In plain wordsIn newborns, hexarelin raised growth hormone.
Peptide
Hexarelin
Outcome
IncreaseDelta GH peak after hexarelin, newborns
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
Delta GH peak
32.8 micrograms/l
newborns
Source sentences
Summary
The mean delta GH peak after HEX in NB (32.8 +/- 4.7 micrograms/l)
1 context sentence(design, population, supporting numbers)
Summary · context
We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC, 9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2 yr) the GH response to Hexarelin (HEX, 2 micrograms/kg i.v.) compared to that observed after GHRH (1 microgram/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6…
Report a problemFND-0940190501
06HumanNon-randomized trialActivity measurement
In newborns, the GH response to hexarelin was lower than the response to GHRH.
In plain wordsIn newborns, hexarelin released less growth hormone than GHRH did.
Peptide
Hexarelin
Outcome
DecreaseGH response, hexarelin vs GHRH in newborns
Study
n = 6
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Source sentences
Summary
In NB, the GH response to HEX was lower (p < 0.005) than to GHRH
1 context sentence(design, population, supporting numbers)
Summary · context
We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC, 9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2 yr) the GH response to Hexarelin (HEX, 2 micrograms/kg i.v.) compared to that observed after GHRH (1 microgram/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6…
Report a problemFND-0940190504

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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