Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.

Zheng H, Bailey A, Jiang MH, Honda K, Chen HY, Trumbauer ME, Van der Ploeg LH, Schaeffer JM, Leng G, Smith RG

Molecular endocrinology (Baltimore, Md.)1 Oct 1997Cited by 112 (Europe PMC)

PMID9328352DOI10.1210/mend.11.11.0016PepBankPUB-09328352

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MK-677 (ibutamoren).

01AnimalNot a test of MK-677 (ibutamoren) aloneAnimal study (in vivo)Mechanism
In mice, GH pretreatment blocked MK-0677 activation of arcuate neurons.
In plain wordsIn mice, growth hormone pretreatment blocked MK-0677 activation of arcuate neurons.
Peptide
MK-677 (ibutamoren)
Outcome
DecreaseNeuronal activation after GH pretreatment
Study
mousen: not reported in source
Somatostatin receptor subtype 2 knockout mice and controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
We show that pretreating mice with GH blocks activation of these neurons by MK-0677.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether this GH-mediated negative feedback on GHRH neurons was direct, or by GH stimulation of somatostatin release from periventricular neurons, we selectively inactivated the gene for one of the five specific somatostatin receptor subtypes (subtype 2).
In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).
Report a problemFND-0932835201
02AnimalNot a test of MK-677 (ibutamoren) aloneAnimal study (in vivo)Mechanism
In mice, octreotide inhibited MK-0677 action on arcuate neurons.
In plain wordsIn mice, octreotide inhibited MK-0677 action on arcuate neurons.
Peptide
MK-677 (ibutamoren)
Outcome
DecreaseNeuronal activation after octreotide
Study
mousen: not reported in source
Somatostatin receptor subtype 2 knockout mice and controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Similarly, octreotide inhibited the action of MK-0677.
2 context sentences(design, population, supporting numbers)
Summary · context
We show that pretreating mice with GH blocks activation of these neurons by MK-0677.
Summary · context
To determine whether this GH-mediated negative feedback on GHRH neurons was direct, or by GH stimulation of somatostatin release from periventricular neurons, we selectively inactivated the gene for one of the five specific somatostatin receptor subtypes (subtype 2).
In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).
Report a problemFND-0932835202
03AnimalNot a test of MK-677 (ibutamoren) aloneAnimal study (in vivo)Mechanism
In receptor-knockout mice, GH failed to inhibit MK-0677 activation of arcuate neurons.
In plain wordsIn receptor-knockout mice, growth hormone failed to inhibit MK-0677 activation of arcuate neurons.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeGH inhibition in knockout mice
Study
mousen: not reported in source
Somatostatin receptor subtype 2 knockout mice
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
In the knockout mice, both GH and octreotide failed to inhibit MK-0677 activation of arcuate neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether this GH-mediated negative feedback on GHRH neurons was direct, or by GH stimulation of somatostatin release from periventricular neurons, we selectively inactivated the gene for one of the five specific somatostatin receptor subtypes (subtype 2).
In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).
Report a problemFND-0932835203
04AnimalNot a test of MK-677 (ibutamoren) aloneAnimal study (in vivo)Mechanism
In receptor-knockout mice, octreotide failed to inhibit MK-0677 activation of arcuate neurons.
In plain wordsIn receptor-knockout mice, octreotide failed to inhibit MK-0677 activation of arcuate neurons.
Peptide
MK-677 (ibutamoren)
Outcome
No significant changeOctreotide inhibition in knockout mice
Study
mousen: not reported in source
Somatostatin receptor subtype 2 knockout mice
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
In the knockout mice, both GH and octreotide failed to inhibit MK-0677 activation of arcuate neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether this GH-mediated negative feedback on GHRH neurons was direct, or by GH stimulation of somatostatin release from periventricular neurons, we selectively inactivated the gene for one of the five specific somatostatin receptor subtypes (subtype 2).
In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).
Report a problemFND-0932835204
05AnimalNot a test of MK-677 (ibutamoren) aloneAnimal study (in vivo)Mechanism
In mice, GH increased Fos immunoreactivity in the periventricular nucleus in the MK-0677 feedback study.
In plain wordsIn mice, growth hormone increased periventricular Fos immunoreactivity in the MK-0677 feedback study.
Peptide
MK-677 (ibutamoren)
Outcome
IncreasePeriventricular Fos immunoreactivity
Study
mousen: not reported in source
Somatostatin receptor subtype 2 knockout mice and controls
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
GH did, however, increase Fos immunoreactivity in the periventricular nucleus, consistent with GH stimulation of somatostatin release from periventricular neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
To determine whether this GH-mediated negative feedback on GHRH neurons was direct, or by GH stimulation of somatostatin release from periventricular neurons, we selectively inactivated the gene for one of the five specific somatostatin receptor subtypes (subtype 2).
In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).
Report a problemFND-0932835205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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Journal Article

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