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Study · Animal study (in vivo) · rat · 1997

11 results

The influence of a novel pentadecapeptide, BPC 157, on N(G)-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure.

Sikirić P, Seiwerth S, Grabarević Z, Rucman R, Petek M, Jagić V, Turković B, Rotkvić I, Mise S, Zoricić I, Konjevoda P, Perović D and 12 more

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Jurina L, Separović J, Hanzevacki M, Artuković B, Bratulić M, Tisljar M, Gjurasin M, Miklić P, Stancić-Rokotov D, Slobodnjak Z, Jelovac N, Marović A

European journal of pharmacology1 Jul 1997Cited by 114 (Europe PMC)

PMID9298922 (opens in a new tab)DOI10.1016/s0014-2999(97)01033-9 (opens in a new tab)PepBankPUB-09298922
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with ethanol-induced gastric lesions, BPC157 given alone had an antiulcer effect.

    In plain wordsIn rats with ethanol-induced stomach lesions, BPC157 given alone protected the stomach lining.

    Peptide
    BPC-157
    Outcome
    DecreaseEthanol-induced gastric lesions
    Study

    ratn: not reported in source

    Ethanol gastric lesion assay
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Given alone, BPC157 had an antiulcer effect, as did L-arginine, but L-NAME had no effect.
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with ethanol-induced gastric lesions, L-NAME only attenuated the antiulcer effect of BPC‑157, while it completely abolished the effect of L-arginine.

    In plain wordsIn rats, an NO blocker only weakened the stomach protection by BPC‑157, but fully removed that of L-arginine.

    Peptide
    BPC-157
    Outcome
    MixedBPC 157 antiulcer effect with L-NAME
    Study

    ratn: not reported in source

    Ethanol gastric lesion assay with L-NAME
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    L-NAME completely abolished the effect of L-arginine, whereas it only attenuated the effect of BPC 157.
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with ethanol-induced gastric lesions, the BPC157 effect was additionally impaired after the combination of L-NAME and L-arginine.

    In plain wordsIn rats, the stomach protection by BPC157 was further weakened when L-NAME and L-arginine were given together.

    Peptide
    BPC-157
    Outcome
    MixedBPC 157 antiulcer effect with L-NAME plus L-arginine
    Study

    ratn: not reported in source

    Ethanol gastric lesion assay with L-NAME plus L-arginine
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    After application of the combination of L-NAME + L-arginine, the BPC157 effect was additionally impaired.
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rats, BPC‑157 had no effect on basal normal blood pressure values.

    In plain wordsIn rats, BPC‑157 did not change normal blood pressure.

    Peptide
    BPC-157
    Outcome
    No significant changeBasal normal blood pressure
    Study

    ratn: not reported in source

    Blood pressure assay
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 microg or 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    (without effect on basal normal values) had both a mimicking effect (impaired L-NAME-blood pressure increase, when applied prophylactically and decreased already raised L-NAME values, given at the time of the maximal L-NAME-blood pressure increase (i.e., 10 min after L-NAME)) and preventive activity…
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats given L-NAME, BPC‑157 applied prophylactically impaired the L-NAME blood pressure increase, mimicking L-arginine.

    In plain wordsIn rats given L-NAME, BPC‑157 given beforehand reduced the blood pressure rise, like L-arginine.

    Peptide
    BPC-157
    Outcome
    DecreaseL-NAME blood pressure increase, prophylactic BPC 157
    Study

    ratn: not reported in source

    Blood pressure assay with L-NAME
    Comparator
    L-arginine
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 microg or 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    compared with L-arginine, pentadecapeptide BPC 157 (without effect on basal normal values) had both a mimicking effect (impaired L-NAME-blood pressure increase, when applied prophylactically and decreased already raised L-NAME values, given at the time of the maximal L-NAME-blood pressure increase (…
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats given L-NAME, BPC‑157 given at the time of the maximal blood pressure increase decreased the already raised blood pressure, mimicking L-arginine.

    In plain wordsIn rats given L-NAME, BPC‑157 given at the peak lowered the raised blood pressure, like L-arginine.

    Peptide
    BPC-157
    Outcome
    DecreaseAlready raised L-NAME blood pressure, BPC 157 at maximal increase
    Study

    ratn: not reported in source

    Blood pressure assay with L-NAME
    Comparator
    L-arginine
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 microg or 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    compared with L-arginine, pentadecapeptide BPC 157 (without effect on basal normal values) had both a mimicking effect (impaired L-NAME-blood pressure increase, when applied prophylactically and decreased already raised L-NAME values, given at the time of the maximal L-NAME-blood pressure increase (…
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats given L-arginine, BPC‑157 pretreatment prevented the moderate L-arginine-induced blood pressure decrease.

    In plain wordsIn rats given L-arginine, BPC‑157 given beforehand prevented the moderate drop in blood pressure.

    Peptide
    BPC-157
    Outcome
    No significant changeL-arginine-induced blood pressure decrease, BPC 157 pretreatment
    Study

    ratn: not reported in source

    Blood pressure assay with L-arginine
    Comparator
    L-arginine alone
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 microg or 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    preventive activity (L-arginine-induced moderate blood pressure decrease was prevented by BPC 157 pretreatment)
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats given the L-NAME plus L-arginine combination, BPC‑157 given 10 min later no longer had its previous blood pressure effect.

    In plain wordsIn rats given L-NAME and L-arginine together, BPC‑157 given 10 min later no longer changed blood pressure as before.

    Peptide
    BPC-157
    Outcome
    No significant changeBPC 157 blood pressure effect after L-NAME plus L-arginine
    Study

    ratn: not reported in source

    Blood pressure assay with L-NAME plus L-arginine
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 microg or 10 ng/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    When BPC 157 was given 10 min after L-NAME + L-arginine combination, which still led to a blood pressure increase, its previously clear effect (noted in L-NAME treated rats) disappeared.
    1 context sentence
    Summary · context
    were investigated in rats challenged with a combination of N(G)-nitro-L-arginine methylester (L-NAME) (5 mg/kg i.v.), a competitive inhibitor of endothelium nitric oxide (NO)-generation and NO precursor, L-arginine (200 mg/kg i.v.)
  9. 09LabEx vivo tissueMechanism

    In rat gastric mucosa homogenates, BPC‑157 at 100 microM induced nitric oxide generation comparable to L-arginine.

    In plain wordsIn lab tests on rat stomach tissue, BPC‑157 produced nitric oxide at a level comparable to L-arginine.

    Peptide
    BPC-157
    Outcome
    IncreaseNitric oxide generation in gastric mucosa homogenates
    Study

    ratn: not reported in source

    Rat gastric mucosa tissue homogenates
    Comparator
    L-arginine
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    100 microMAs given in this study (rat).

    Source sentences

    Summary
    In vitro, in gastric mucosa from rat stomach tissue homogenates, BPC 157, given in the same dose (100 microM) as L-arginine, induced a comparable generation of NO.
  10. 10LabEx vivo tissueMechanism

    In rat gastric mucosa homogenates, L-NAME did not inhibit the nitric oxide generation induced by BPC‑157, even at a tenfold higher dose.

    In plain wordsIn lab tests on rat stomach tissue, the NO blocker L-NAME did not stop BPC‑157 from producing nitric oxide.

    Peptide
    BPC-157
    Outcome
    No significant changeL-NAME inhibition of BPC 157-induced nitric oxide generation
    Study

    ratn: not reported in source

    Rat gastric mucosa tissue homogenates
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    100 microMAs given in this study (rat).

    Source sentences

    Summary
    But, BPC 157 effect could not be inhibited by L-NAME, even when L-NAME was given in a tenfold (100 versus 1000 microM) higher dose than that needed for inhibition of the L-arginine effect.
    1 context sentence
    Summary · context
    In vitro, in gastric mucosa from rat stomach tissue homogenates, BPC 157, given in the same dose (100 microM) as L-arginine, induced a comparable generation of NO.
  11. 11LabEx vivo tissueMechanism

    In rat gastric mucosa homogenates, nitric oxide synthesis was blunted when BPC‑157 and L-arginine were combined.

    In plain wordsIn lab tests on rat stomach tissue, combining BPC‑157 and L-arginine reduced nitric oxide production.

    Peptide
    BPC-157
    Outcome
    DecreaseNitric oxide synthesis with BPC 157 plus L-arginine
    Study

    ratn: not reported in source

    Rat gastric mucosa tissue homogenates
    Comparator
    L-arginine alone
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    100 microMAs given in this study (rat).

    Source sentences

    Summary
    NO synthesis was blunted when the pentadecapeptide BPC 157 and L-arginine were combined.
    1 context sentence
    Summary · context
    In vitro, in gastric mucosa from rat stomach tissue homogenates, BPC 157, given in the same dose (100 microM) as L-arginine, induced a comparable generation of NO.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

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