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Study · Ex vivo tissue · rat and dog · 1997

10 results

Hepatic extraction of hexarelin, a new peptidic GH secretagogue, in the isolated perfused rat liver.

Roumi M, Marleau S, Boghen M, Nilsson M, Du Souich P, Ong H

Pharmaceutical research1 Aug 1997Cited by 3 (Europe PMC)

PMID9279881 (opens in a new tab)DOI10.1023/a:1012193010009 (opens in a new tab)PepBankPUB-09279881
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    In the isolated perfused rat liver, the disappearance rate constant of hexarelin was 0.013-0.014 per minute across the concentrations tested.

    In plain wordsIn lab tests with rat liver, hexarelin disappeared from the perfusate at a similar rate at all three concentrations.

    Peptide
    Hexarelin
    Outcome
    Not applicableDisappearance rate constant in perfused liver
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    5, 50 and 500 ng/mlAs given in this study (rat).

    Measurements

    Disappearance rate constant
    0.013 to 0.014 min-1
    perfused rat liver

    Source sentences

    Summary
    The disappearance rate constant (K), half-life (t1/2), clearance (Cl), and hepatic extraction ratio (E) were: K = 0.013-0.014 min-1, t1/2 = 45-55 min, Cl = 0.345-0.401 ml/min/g liver, and E = 19-21% for the different concentrations of HEX.
    1 context sentence
    Summary · context
    Three HEX concentrations of 5, 50, and 500 ng/ml were examined.
  2. 02LabEx vivo tissuePharmacokinetics

    In the isolated perfused rat liver, the half-life of hexarelin was 45-55 minutes.

    In plain wordsIn lab tests with rat liver, the half-life of hexarelin was 45 to 55 minutes.

    Peptide
    Hexarelin
    Outcome
    Not applicableHalf-life in perfused liver
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    5, 50 and 500 ng/mlAs given in this study (rat).

    Measurements

    Half-life
    45 to 55 min
    perfused rat liver

    Source sentences

    Summary
    The disappearance rate constant (K), half-life (t1/2), clearance (Cl), and hepatic extraction ratio (E) were: K = 0.013-0.014 min-1, t1/2 = 45-55 min, Cl = 0.345-0.401 ml/min/g liver, and E = 19-21% for the different concentrations of HEX.
    1 context sentence
    Summary · context
    Three HEX concentrations of 5, 50, and 500 ng/ml were examined.
  3. 03LabEx vivo tissuePharmacokinetics

    In the isolated perfused rat liver, hexarelin clearance was 0.345-0.401 ml/min/g liver and did not depend on concentration.

    In plain wordsIn lab tests with rat liver, hexarelin clearance did not depend on how much hexarelin was present.

    Peptide
    Hexarelin
    Outcome
    Not applicableHepatic clearance in perfused liver
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    5, 50 and 500 ng/mlAs given in this study (rat).

    Measurements

    Clearance
    0.345 to 0.401 ml/min/g liver
    perfused rat liver

    Source sentences

    Summary
    The disappearance rate constant (K), half-life (t1/2), clearance (Cl), and hepatic extraction ratio (E) were: K = 0.013-0.014 min-1, t1/2 = 45-55 min, Cl = 0.345-0.401 ml/min/g liver, and E = 19-21% for the different concentrations of HEX.
    1 context sentence
    Summary · context
    These results show that 1) the hepatic extraction of HEX is low, 2) the hepatic clearance is concentration independent up to 500 ng HEX/ml of perfusate, and 3) the plasma protein binding of HEX is significant over the dose range studied.
  4. 04LabEx vivo tissuePharmacokinetics

    In the isolated perfused rat liver, the hepatic extraction ratio of hexarelin was low, at 19-21%.

    In plain wordsIn lab tests with rat liver, the liver removed only a small share of hexarelin, 19 to 21 percent.

    Peptide
    Hexarelin
    Outcome
    Not applicableHepatic extraction ratio in perfused liver
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    5, 50 and 500 ng/mlAs given in this study (rat).

    Measurements

    Hepatic extraction ratio
    19 to 21%
    perfused rat liver

    Source sentences

    Summary
    The disappearance rate constant (K), half-life (t1/2), clearance (Cl), and hepatic extraction ratio (E) were: K = 0.013-0.014 min-1, t1/2 = 45-55 min, Cl = 0.345-0.401 ml/min/g liver, and E = 19-21% for the different concentrations of HEX.
    1 context sentence
    Summary · context
    HEX exhibits a low hepatic extraction ratio, allowing us to predict that its hepatic clearance may be limited upon HEX protein binding.
  5. 05LabEx vivo tissuePharmacokinetics

    In the isolated perfused rat liver, the area under the curve of hexarelin increased linearly with concentration.

    In plain wordsIn lab tests with rat liver, the hexarelin exposure rose in step with the concentration.

    Peptide
    Hexarelin
    Outcome
    IncreaseAUC in perfused liver across concentrations
    Study

    ratn: not reported in source

    Isolated perfused rat liver
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    5, 50 and 500 ng/mlAs given in this study (rat).

    Measurements

    AUC
    270 to 24,334 min pmol/ml
    perfused rat liver

    Source sentences

    Summary
    A linear increase in AUC (270-24334 min pmol/ml) was observed with increasing concentrations.
    1 context sentence
    Summary · context
    Three HEX concentrations of 5, 50, and 500 ng/ml were examined.
  6. 06LabIn vitro (cell-free)Pharmacokinetics

    In rat plasma, 68.7% of hexarelin was bound to plasma proteins.

    In plain wordsIn lab tests, most of the hexarelin bound to proteins in rat plasma.

    Peptide
    Hexarelin
    Outcome
    Not applicablePlasma protein binding, rat
    Study

    ratn: not reported in source

    Plasma, ultrafiltration
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Plasma protein binding
    68.7%
    rat

    Source sentences

    Summary
    Binding of HEX to plasma proteins of rats, dogs, pigs, and humans was 68.7 +/- 0.8%, 78.7 +/- 0.6%, 67.3 +/- 0.7%, and 65.2 +/- 0.6% respectively
    1 context sentence
    Summary · context
    In vitro plasma binding was determined by the ultrafiltration method.
  7. 07LabIn vitro (cell-free)Pharmacokinetics

    In dog plasma, 78.7% of hexarelin was bound to plasma proteins.

    In plain wordsIn lab tests, most of the hexarelin bound to proteins in dog plasma.

    Peptide
    Hexarelin
    Outcome
    Not applicablePlasma protein binding, dog
    Study

    dogn: not reported in source

    Plasma, ultrafiltration
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Plasma protein binding
    78.7%
    dog

    Source sentences

    Summary
    Binding of HEX to plasma proteins of rats, dogs, pigs, and humans was 68.7 +/- 0.8%, 78.7 +/- 0.6%, 67.3 +/- 0.7%, and 65.2 +/- 0.6% respectively
    1 context sentence
    Summary · context
    In vitro plasma binding was determined by the ultrafiltration method.
  8. 08LabIn vitro (cell-free)Pharmacokinetics

    In pig plasma, 67.3% of hexarelin was bound to plasma proteins.

    In plain wordsIn lab tests, most of the hexarelin bound to proteins in pig plasma.

    Peptide
    Hexarelin
    Outcome
    Not applicablePlasma protein binding, pig
    Study

    pign: not reported in source

    Plasma, ultrafiltration
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Plasma protein binding
    67.3%
    pig

    Source sentences

    Summary
    Binding of HEX to plasma proteins of rats, dogs, pigs, and humans was 68.7 +/- 0.8%, 78.7 +/- 0.6%, 67.3 +/- 0.7%, and 65.2 +/- 0.6% respectively
    1 context sentence
    Summary · context
    In vitro plasma binding was determined by the ultrafiltration method.
  9. 09LabIn vitro (cell-free)Pharmacokinetics

    In human plasma, 65.2% of hexarelin was bound to plasma proteins.

    In plain wordsIn lab tests, most of the hexarelin bound to proteins in human plasma.

    Peptide
    Hexarelin
    Outcome
    Not applicablePlasma protein binding, human
    Study

    humann: not reported in source

    Plasma, ultrafiltration
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    Plasma protein binding
    65.2%
    human

    Source sentences

    Summary
    Binding of HEX to plasma proteins of rats, dogs, pigs, and humans was 68.7 +/- 0.8%, 78.7 +/- 0.6%, 67.3 +/- 0.7%, and 65.2 +/- 0.6% respectively
    1 context sentence
    Summary · context
    In vitro plasma binding was determined by the ultrafiltration method.
  10. 10LabIn vitro (cell-free)Pharmacokinetics

    In plasma from four species, hexarelin plasma binding did not depend on concentration between 0.003 and 3 microM.

    In plain wordsIn lab tests with plasma from four species, hexarelin binding to proteins stayed the same across the concentrations tested.

    Peptide
    Hexarelin
    Outcome
    No significant changeConcentration dependence of plasma binding
    Study

    rat, dog, pig, humann: not reported in source

    Plasma, ultrafiltration
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.003-3 microMAs given in this study (rat, dog, pig, human).

    Source sentences

    Summary
    Plasma binding was concentration-independent in the range between 0.003-3 microM for the four species examined.
    1 context sentence
    Summary · context
    In vitro plasma binding was determined by the ultrafiltration method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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