Nebulized glutathione induces bronchoconstriction in patients with mild asthma.

Marrades RM, Roca J, Barberà JA, de Jover L, MacNee W, Rodriguez-Roisin R

American journal of respiratory and critical care medicine1 Aug 1997Cited by 52 (Europe PMC)

PMID9279219DOI10.1164/ajrccm.156.2.9611001PepBankPUB-09279219

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialSafety outcome
In patients with mild asthma, nebulized glutathione reduced FEV1 more than placebo.
In plain wordsIn patients with mild asthma, inhaled glutathione reduced lung function more than placebo.
Peptide
Glutathione
Outcome
DecreaseFEV1 after challenge
Study
n = 8
Comparator
Placebo saline
Outcome group
Adverse events · Respiratory
Studied dose
600 mg · nebulized · 25 minAs given in this study (human).
Measurements
FEV1 change from baseline
−1%
Placebo after challenge
FEV1 change from baseline
−19%
GSH after challenge
P value for FEV1 after challenge
0.03
Placebo versus GSH after challenge
Source sentences
Summary
Placebo provoked subclinical mild bronchoconstriction (changes from baseline: FEV1, -1%; Rrs, +17%); by contrast, GSH caused major airway narrowing (changes from baseline: FEV1, -19%; Rrs, +61%) and induced cough (four patients) or breathlessness (three patients).
3 context sentences(design, population, supporting numbers)
Summary · context
Differences between placebo and GSH after challenge were also noticeable in both FEV1 (p = 0.03) and Rrs (p = 0.02).
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
Report a problemFND-0927921901
02HumanRandomized controlled trialSafety outcome
In patients with mild asthma, nebulized glutathione increased pulmonary resistance more than placebo.
In plain wordsIn patients with mild asthma, inhaled glutathione increased airway resistance more than placebo.
Peptide
Glutathione
Outcome
IncreaseTotal pulmonary resistance
Study
n = 8
Comparator
Placebo saline
Outcome group
Adverse events · Respiratory
Studied dose
600 mg · nebulized · 25 minAs given in this study (human).
Measurements
Total pulmonary resistance change from baseline
17%
Placebo after challenge
Total pulmonary resistance change from baseline
61%
GSH after challenge
P value for total pulmonary resistance after challenge
0.02
Placebo versus GSH after challenge
Source sentences
Summary
Placebo provoked subclinical mild bronchoconstriction (changes from baseline: FEV1, -1%; Rrs, +17%); by contrast, GSH caused major airway narrowing (changes from baseline: FEV1, -19%; Rrs, +61%) and induced cough (four patients) or breathlessness (three patients).
3 context sentences(design, population, supporting numbers)
Summary · context
Differences between placebo and GSH after challenge were also noticeable in both FEV1 (p = 0.03) and Rrs (p = 0.02).
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
Report a problemFND-0927921902
03HumanRandomized controlled trialSafety outcome
In patients with mild asthma, nebulized glutathione induced cough in four patients.
In plain wordsIn patients with mild asthma, inhaled glutathione caused cough in four patients.
Peptide
Glutathione
Outcome
Not applicableCough
Study
n = 8
Outcome group
Adverse events · Respiratory
Studied dose
600 mg · nebulized · 25 minAs given in this study (human).
Measurements
Patients with cough
4 patients
GSH challenge
Source sentences
Summary
by contrast, GSH caused major airway narrowing (changes from baseline: FEV1, -19%; Rrs, +61%) and induced cough (four patients) or breathlessness (three patients).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
Report a problemFND-0927921903
04HumanRandomized controlled trialSafety outcome
In patients with mild asthma, nebulized glutathione induced breathlessness in three patients.
In plain wordsIn patients with mild asthma, inhaled glutathione caused breathlessness in three patients.
Peptide
Glutathione
Outcome
Not applicableBreathlessness
Study
n = 8
Outcome group
Adverse events · Respiratory
Studied dose
600 mg · nebulized · 25 minAs given in this study (human).
Measurements
Patients with breathlessness
3 patients
GSH challenge
Source sentences
Summary
by contrast, GSH caused major airway narrowing (changes from baseline: FEV1, -19%; Rrs, +61%) and induced cough (four patients) or breathlessness (three patients).
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
Report a problemFND-0927921904
05HumanRandomized controlled trialMechanism
In patients with mild asthma, glutathione-induced FEV1 falls correlated inversely with metabisulfite bronchoprovocation.
In plain wordsIn patients with mild asthma, glutathione-related lung function falls were inversely linked to metabisulfite challenge responses.
Peptide
Glutathione
Outcome
DecreaseFEV1 fall association with metabisulfite response
Study
n = 8
Outcome group
Adverse events · Respiratory
Studied dose
600 mg · nebulized · 25 minAs given in this study (human).
Source sentences
Summary
Furthermore, GSH-induced FEV1 falls were inversely correlated with metabisulfite bronchoprovocation (provocative dose [PD20], 1.49 +/- 1.83 mumol) but not with methacholine challenge.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
Report a problemFND-0927921908
06HumanRandomized controlled trialMechanism
In patients with mild asthma, glutathione-induced FEV1 falls did not correlate with methacholine challenge.
In plain wordsIn patients with mild asthma, glutathione-related lung function falls were not linked to methacholine challenge responses.
Peptide
Glutathione
Outcome
No significant changeFEV1 fall association with methacholine response
Study
n = 8
Outcome group
Receptor activity and mechanism · Respiratory
Studied dose
600 mg · nebulized · 25 minAs given in this study (human).
Source sentences
Summary
Furthermore, GSH-induced FEV1 falls were inversely correlated with metabisulfite bronchoprovocation (provocative dose [PD20], 1.49 +/- 1.83 mumol) but not with methacholine challenge.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
Report a problemFND-0927921909

Studies that did not test the peptide alone3

In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Glutathione.

07HumanNot a test of Glutathione aloneRandomized controlled trialMechanism
In patients with mild asthma, glutathione solution osmolarity did not account for airway effects.
In plain wordsIn patients with mild asthma, the glutathione solution's osmolarity did not explain the airway effects.
Peptide
Glutathione
Outcome
Not applicableOsmolarity contribution to bronchoconstriction
Study
n = 8
Outcome group
Adverse events · Respiratory
Measurements
GSH solution osmolarity
660 mosm.kg-1
GSH solution assessed as an explanation for airway effects
Source sentences
Summary
Neither osmolarity (660 mosm.kg-1) nor pH (3.0) of the GSH solution accounted for these effects.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-0927921905
08HumanNot a test of Glutathione aloneRandomized controlled trialMechanism
In patients with mild asthma, glutathione solution pH did not account for airway effects.
In plain wordsIn patients with mild asthma, the glutathione solution's acidity did not explain the airway effects.
Peptide
Glutathione
Outcome
Not applicablepH contribution to bronchoconstriction
Study
n = 8
Outcome group
Adverse events · Respiratory
Measurements
GSH solution pH
3
GSH solution assessed as an explanation for airway effects
Source sentences
Summary
Neither osmolarity (660 mosm.kg-1) nor pH (3.0) of the GSH solution accounted for these effects.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-0927921906
09HumanNot a test of Glutathione aloneRandomized controlled trialMechanism
In patients with mild asthma, salbutamol before glutathione challenge blocked glutathione-induced bronchoconstriction.
In plain wordsIn patients with mild asthma, salbutamol before glutathione challenge blocked airway narrowing.
Peptide
Glutathione
Outcome
DecreaseSalbutamol blockade of bronchoconstriction
Study
n = 8
Outcome group
Adverse events · Respiratory
Source sentences
Summary
Nebulized salbutamol (5.0 mg) given before the GSH challenge blocked GSH-induced bronchoconstriction.
2 context sentences(design, population, supporting numbers)
Summary · context
To assess the effects on bronchial responsiveness of nebulized glutathione (GSH), one of the most efficient scavengers of oxidant substances in the airways, we studied eight patients with mild asthma (FEV1, 88 +/- 11% predicted [SD]) in a randomized, double-blind, cross-over, placebo-controlled fashion.
Summary · context
Patients received nebulized GSH (600 mg with 4 ml of 0.9% sodium chloride) or placebo (identical saline solution) over a period of 25 min, 1 wk apart.
In this study, Glutathione was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Glutathione.
Report a problemFND-0927921907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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