Effect of desmopressin on ACTH and cortisol secretion in states of ACTH excess.

Colombo P, Passini E, Re T, Faglia G, Ambrosi B

Clinical endocrinology1 Jun 1997Cited by 43 (Europe PMC)

PMID9274696DOI10.1046/j.1365-2265.1997.1330954.xPepBankPUB-09274696

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone9

In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Desmopressin.

01HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In Cushing microadenoma, ACTH/cortisol rose in 11 patients after both tests, two only after desmopressin, and two only after CRH, with one equivocal response.
In plain wordsIn Cushing microadenoma, 11 responded to both tests, two only to desmopressin, two only to CRH, and one had equivocal responses.
Peptide
Desmopressin
Outcome
IncreaseACTH response in Cushing microadenoma
Study
n = 16
Outcome group
Hormone levels · Endocrine and hormones
Measurements
Patients with positive ACTH/cortisol rise after both desmopressin and CRH
11 patients
Cushing's disease with microadenoma
Patients responsive only to desmopressin
2 patients
Cushing's disease with microadenoma
Patients responsive only to CRH
2 patients
Cushing's disease with microadenoma
Patients with equivocal responses to both tests
1 patients
Cushing's disease with microadenoma
Source sentences
Summary
In 16 patients with Cushing's disease with microadenoma a positive ACTH/cortisol rise occurred in 11 patients after both desmopressin and CRH, 2 other patients were responsive only to desmopressin and 2 only to CRH, while in 1 patient equivocal responses to both tests were found.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469601
02HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In Cushing microadenoma, cortisol rose in 11 patients after both tests and in two additional patients only after desmopressin.
In plain wordsIn Cushing microadenoma, cortisol rose in 11 patients after both tests and in two additional patients only after desmopressin.
Peptide
Desmopressin
Outcome
IncreaseCortisol response in Cushing microadenoma
Study
n = 16
Outcome group
Hormone levels · Endocrine and hormones
Measurements
Patients with positive ACTH/cortisol rise after both desmopressin and CRH
11 patients
Cushing's disease with microadenoma
Patients responsive only to desmopressin
2 patients
Cushing's disease with microadenoma
Patients responsive only to CRH
2 patients
Cushing's disease with microadenoma
Patients with equivocal responses to both tests
1 patients
Cushing's disease with microadenoma
Source sentences
Summary
In 16 patients with Cushing's disease with microadenoma a positive ACTH/cortisol rise occurred in 11 patients after both desmopressin and CRH, 2 other patients were responsive only to desmopressin and 2 only to CRH, while in 1 patient equivocal responses to both tests were found.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469602
03HumanNot a test of Desmopressin aloneNon-randomized trialOther
In Cushing's disease, persistent postoperative desmopressin hormonal response correlated with unsuccessful surgery.
In plain wordsIn Cushing's disease, a persistent hormonal response to desmopressin after surgery was linked to unsuccessful surgery.
Peptide
Desmopressin
Outcome
Not applicablePostoperative hormonal response and surgical outcome
Study
n = 13
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
The persistence of a hormonal response to desmopressin after pituitary adenomectomy for Cushing's disease correlated with unsuccessful surgery, while, contrary to CRH, absent ACTH/cortisol rises were found in cured patients 1 and 12 months after operation.
2 context sentences(design, population, supporting numbers)
Summary · context
After pituitary adenomectomy desmopressin and CRH were administered again to 13 of the patients who had undergone pituitary surgery for their Cushing's disease.
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469603
04HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In patients with Addison's disease, ACTH increased significantly after desmopressin testing.
In plain wordsIn patients with Addison's disease, ACTH increased significantly after desmopressin testing.
Peptide
Desmopressin
Outcome
IncreaseACTH response in Addison's disease
Study
n = 5
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
Significant ACTH rises occurred after both desmopressin and CRH testing in patients with Addison's disease.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469608
05HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
Among three adrenalectomized Cushing patients, one showed an ACTH rise after desmopressin, compared with all three after CRH.
In plain wordsAmong three adrenalectomized Cushing patients, one showed an ACTH rise after desmopressin, compared with all three after CRH.
Peptide
Desmopressin
Outcome
MixedACTH response after adrenalectomy
Study
n = 3
Comparator
CRH
Outcome group
Hormone levels · Endocrine and hormones
Measurements
Patients with ACTH rise after desmopressin
1 patients
of 3 patients adrenalectomized for Cushing's syndrome
Source sentences
Summary
All the 3 patients adrenalectomized for Cushing's syndrome showed a rise of ACTH levels after CRH, while a similar response after desmopressin occurred in only one of them.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469609
06HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In one patient with suspected ectopic ACTH hypersecretion, desmopressin caused no ACTH rise.
In plain wordsIn one patient with suspected ectopic ACTH hypersecretion, desmopressin caused no ACTH rise.
Peptide
Desmopressin
Outcome
No significant changeACTH response in suspected ectopic hypersecretion
Study
n = 1
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
In 1 patient suspected for ectopic ACTH hypersecretion, desmopressin and CRH administration did not cause any ACTH/cortisol rise.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469606
07HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In one patient with suspected ectopic ACTH hypersecretion, desmopressin caused no cortisol rise.
In plain wordsIn one patient with suspected ectopic ACTH hypersecretion, desmopressin caused no cortisol rise.
Peptide
Desmopressin
Outcome
No significant changeCortisol response in suspected ectopic hypersecretion
Study
n = 1
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
In 1 patient suspected for ectopic ACTH hypersecretion, desmopressin and CRH administration did not cause any ACTH/cortisol rise.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469607
08HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In cured Cushing patients, desmopressin produced no ACTH rise at 1 and 12 months after surgery, unlike CRH.
In plain wordsIn cured Cushing patients, desmopressin produced no ACTH rise after surgery, unlike CRH.
Peptide
Desmopressin
Outcome
No significant changePostoperative ACTH response in cured patients
Study
n: not reported in source
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
The persistence of a hormonal response to desmopressin after pituitary adenomectomy for Cushing's disease correlated with unsuccessful surgery, while, contrary to CRH, absent ACTH/cortisol rises were found in cured patients 1 and 12 months after operation.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469604
09HumanNot a test of Desmopressin aloneNon-randomized trialActivity measurement
In cured Cushing patients, desmopressin produced no cortisol rise at 1 and 12 months after surgery, unlike CRH.
In plain wordsIn cured Cushing patients, desmopressin produced no cortisol rise after surgery, unlike CRH.
Peptide
Desmopressin
Outcome
No significant changePostoperative cortisol response in cured patients
Study
n: not reported in source
Outcome group
Hormone levels · Endocrine and hormones
Source sentences
Summary
The persistence of a hormonal response to desmopressin after pituitary adenomectomy for Cushing's disease correlated with unsuccessful surgery, while, contrary to CRH, absent ACTH/cortisol rises were found in cured patients 1 and 12 months after operation.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma ACTH and serum cortisol levels were evaluated after the administration of desmopressin (10 micrograms i.v.), CRH (1 microgram/kg i.v.) and saline on different days
In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.
Report a problemFND-0927469605

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.