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Study · Randomized controlled trial · n = 16 · 1997

7 results

Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa.

Giusti M, Foppiani L, Ponzani P, Cuttica CM, Falivene MR, Valenti S

Journal of endocrinological investigation1 May 1997Cited by 7 (Europe PMC)

PMID9258804 (opens in a new tab)DOI10.1007/bf03350297 (opens in a new tab)PepBankPUB-09258804
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialActivity measurement

    The GH peak after hexarelin was lower in women with anorexia nervosa than in controls.

    In plain wordsHexarelin raised the growth hormone peak less in women with anorexia nervosa than in healthy women.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH peak after hexarelin, controls vs anorexia nervosa
    Study

    n = 16

    Comparator
    Normal cycling women
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    HEX produced a significantly (p < 0.05) higher GH peak in controls than in AN, while GH AUC was slightly but not significantly higher.
    2 context sentences
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.
  2. 02HumanRandomized controlled trialActivity measurement

    The GH area under the curve after hexarelin did not differ significantly between controls and women with anorexia nervosa.

    In plain wordsThe total growth hormone release after hexarelin was not significantly different between women with anorexia nervosa and healthy women.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH AUC after hexarelin, controls vs anorexia nervosa
    Study

    n = 16

    Comparator
    Normal cycling women
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    HEX produced a significantly (p < 0.05) higher GH peak in controls than in AN, while GH AUC was slightly but not significantly higher.
    2 context sentences
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.
  3. 03HumanRandomized controlled trialActivity measurement

    In women with anorexia nervosa, hexarelin was not a stronger GH-releasing peptide than GHRH.

    In plain wordsIn women with anorexia nervosa, hexarelin did not release more growth hormone than GHRH.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response, hexarelin vs GHRH in anorexia nervosa
    Study

    n = 9

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Title
    Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa.
    3 context sentences
    Summary · context
    Indeed, only in controls, HEX was a stronger GH-releasing peptide than GHRH.
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.
  4. 04HumanRandomized controlled trialActivity measurement

    In women with anorexia nervosa, hexarelin did not produce a persistent prolactin release.

    In plain wordsIn women with anorexia nervosa, hexarelin did not cause a lasting rise in prolactin.

    Peptide
    Hexarelin
    Outcome
    No significant changeProlactin release after hexarelin, anorexia nervosa
    Study

    n = 9

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    in our study HEX was able to produce a persistent PRL release in controls but not in AN
    2 context sentences
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.
  5. 05HumanRandomized controlled trialActivity measurement

    In women with anorexia nervosa, hexarelin stimulated cortisol secretion only transiently.

    In plain wordsIn women with anorexia nervosa, hexarelin raised cortisol only for a short time.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol release after hexarelin, anorexia nervosa
    Study

    n = 9

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    while it stimulated cortisol secretion only transiently in the patients studied.
    2 context sentences
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.
  6. 06HumanRandomized controlled trialActivity measurement

    In normal cycling women, hexarelin was a stronger GH-releasing peptide than GHRH.

    In plain wordsIn healthy women, hexarelin released more growth hormone than GHRH.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response, hexarelin vs GHRH in controls
    Study

    n = 7

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    Indeed, only in controls, HEX was a stronger GH-releasing peptide than GHRH.
    2 context sentences
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.
  7. 07HumanRandomized controlled trialActivity measurement

    In normal cycling women, hexarelin produced a persistent prolactin release.

    In plain wordsIn healthy women, hexarelin caused a lasting rise in prolactin.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin release after hexarelin, controls
    Study

    n = 7

    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    in our study HEX was able to produce a persistent PRL release in controls but not in AN
    2 context sentences
    Summary · context
    The aim of the study was to evaluate the effect of i.v. administration of old (GHRH) and new (HEX) GH-releasing peptides on GH, PRL and cortisol secretion in 9 AN patients in the "recovery phase" of the disease, after partial but significant weight gain.
    Summary · context
    For controls we studied 7 normal cycling women.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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