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Study · Non-randomized trial · n = 14 · 1997

8 results

Absence of desensitization by hexarelin to subsequent GH releasing hormone-mediated GH secretion in patients with anorexia nervosa.

Popovic V, Micic D, Djurovic M, Obradovic S, Casanueva FF, Dieguez C

Clinical endocrinology1 May 1997Cited by 8 (Europe PMC)

PMID9231048 (opens in a new tab)DOI10.1046/j.1365-2265.1997.1650982.x (opens in a new tab)PepBankPUB-09231048
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In women with anorexia nervosa, hexarelin induced a normal GH response.

    In plain wordsIn women with anorexia nervosa, hexarelin raised growth hormone normally.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH peak after hexarelin, anorexia nervosa
    Study

    n = 14

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    64.8 mU/l
    anorexia nervosa

    Source sentences

    Summary
    In contrast, the women with anorexia nervosa showed a normal GH response after the two stimuli: hexarelin 64.8 +/- 9.2.
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  2. 02HumanNon-randomized trialActivity measurement

    In women with anorexia nervosa, hexarelin did not block the GH response to GHRH given 120 minutes later.

    In plain wordsIn women with anorexia nervosa, hexarelin did not block the growth hormone response to GHRH given two hours later.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to GHRH 120 min after hexarelin, anorexia nervosa
    Study

    n = 14

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak after GHRH
    71.1 mU/l
    anorexia nervosa

    Source sentences

    Summary
    In contrast, the women with anorexia nervosa showed a normal GH response after the two stimuli: hexarelin 64.8 +/- 9.2. GHRH 71.1 +/- 14.2.
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  3. 03HumanNon-randomized trialActivity measurement

    In women with amenorrhoea from voluntary weight loss, hexarelin induced a GH peak.

    In plain wordsIn women with amenorrhoea from weight loss, hexarelin raised growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH peak after hexarelin, amenorrhoea from weight loss
    Study

    n = 7

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    60.3 mU/l
    amenorrhoea

    Source sentences

    Summary
    because the women with amenorrhoea due to voluntary weight loss but with a normal energy intake showed a pattern similar to the controls (GH after hexarelin 60.3 +/- 9.5 and to GHRH 120 minutes later 6.2 +/- 1.0 (P < 0.05)).
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  4. 04HumanNon-randomized trialActivity measurement

    In women with amenorrhoea from voluntary weight loss, hexarelin blocked the GH response to GHRH given 120 minutes later, as in controls.

    In plain wordsIn women with amenorrhoea from weight loss, hexarelin blocked the growth hormone response to GHRH given two hours later.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to GHRH 120 min after hexarelin, amenorrhoea from weight loss
    Study

    n = 7

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak after GHRH
    6.2 mU/l
    amenorrhoea

    Source sentences

    Summary
    because the women with amenorrhoea due to voluntary weight loss but with a normal energy intake showed a pattern similar to the controls (GH after hexarelin 60.3 +/- 9.5 and to GHRH 120 minutes later 6.2 +/- 1.0 (P < 0.05)).
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  5. 05HumanNon-randomized trialActivity measurement

    In normal-weight women, hexarelin induced a clear GH peak.

    In plain wordsIn normal-weight women, hexarelin clearly raised growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH peak after hexarelin, normal-weight women
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    77.5 mU/l
    normal-weight women

    Source sentences

    Summary
    The administration of hexarelin to the normal-weight women induced a clear-cut GH secretion (expressed as mean +/- SE of GH peak in mU/l of 77.5 +/- 21.8
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  6. 06HumanNon-randomized trialActivity measurement

    In normal-weight women, hexarelin blocked the GH response to GHRH given 120 minutes later.

    In plain wordsIn normal-weight women, a hexarelin dose blocked the growth hormone response to GHRH given two hours later.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to GHRH 120 min after hexarelin, normal-weight women
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak after GHRH
    6.6 mU/l
    normal-weight women

    Source sentences

    Summary
    but blocked the GH-releasing capability of GHRH administered 120 minutes later (6.6 +/- 2.8, P < 0.05)
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  7. 07HumanNon-randomized trialActivity measurement

    In normal-weight women after a short-term hypocaloric diet, hexarelin induced a GH peak.

    In plain wordsIn normal-weight women after a short low-calorie diet, hexarelin raised growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH peak after hexarelin, short-term hypocaloric diet
    Study

    n = 5

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    99.6 mU/l
    hypocaloric diet

    Source sentences

    Summary
    Similarly, the women after the short-term hypocaloric diet showed a hexarelin-mediated GH secretion of 99.6 +/- 17.8, which blunted the subsequent administration of GHRH (GH mean peak of 9.9 +/- 2.9, P < 0.05 vs hexarelin).
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).
  8. 08HumanNon-randomized trialActivity measurement

    In normal-weight women after a short-term hypocaloric diet, the GH response to GHRH given after hexarelin was blunted.

    In plain wordsIn normal-weight women after a short low-calorie diet, the growth hormone response to GHRH after hexarelin was smaller than after hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to GHRH 120 min after hexarelin, short-term hypocaloric diet
    Study

    n = 5

    Comparator
    GH peak after hexarelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH peak after GHRH
    9.9 mU/l
    hypocaloric diet

    Source sentences

    Summary
    Similarly, the women after the short-term hypocaloric diet showed a hexarelin-mediated GH secretion of 99.6 +/- 17.8, which blunted the subsequent administration of GHRH (GH mean peak of 9.9 +/- 2.9, P < 0.05 vs hexarelin).
    2 context sentences
    Summary · context
    The GH stimuli used were hexarelin (1 micrograms/kg i.v.), a GH stimulus whose main action is hypothalamic, followed 120 minutes later by GHRH (1 micrograms/kg i.v.) as a pituitary stimulus.
    Summary · context
    Thirty-two woman matched for age participated in the study: six normal-weight women as controls, 14 women with anorexia nervosa, seven women with secondary amenorrhoea due to voluntary weight loss for aesthetic reasons, and five normal-weight women after 72 hours of a controlled hypocaloric diet (800 cal/day).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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