Biodistribution of synthetic thymosin beta 4 in the serum, urine, and major organs of mice.

In mice given 400 micrograms of intraperitoneal synthetic thymosin beta‑4, serum thymosin beta‑4 rose significantly from 2 min and stayed raised for 40 min.

In plain wordsIn mice, blood levels of thymosin beta‑4 rose within 2 minutes of injection and stayed raised for 40 minutes.

Measurements

serum thymosin beta 4 concentration

2.34 micrograms/ml

average, 2 to 40 min

Source sentences

In mice, urine thymosin beta‑4 concentrations were high at 20 min, 40 min and 2 h after injection.

In plain wordsIn mice, thymosin beta‑4 levels in urine were high at 20 minutes, 40 minutes and 2 hours after injection.

Measurements

urine thymosin beta 4 concentration

59.3 micrograms/ml

20 min, 40 min, 2 h

Source sentences

In mice, 83% of the injected thymosin beta‑4 was recovered at the end of the study: 44.6% in urine, 1.4% in serum and 37.5% in organs.

In plain wordsIn mice, 83% of the injected thymosin beta‑4 was recovered, mostly in urine and organs, and little in blood.

Measurements

total recovery

83%

of 400 micrograms

urine recovery

44.6%

of dose

serum recovery

1.4%

of dose

organ recovery

37.5%

of dose

Source sentences

In mice, brain thymosin beta‑4 wet weight concentration rose significantly from the first 40 min to 2 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the brain rose after injection compared with baseline.

Measurements

wet weight concentration

72 micrograms/g

brain

Source sentences

In mice, heart thymosin beta‑4 wet weight concentration rose significantly from the first 40 min to 2 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the heart rose after injection compared with baseline.

Measurements

wet weight concentration

80 micrograms/g

heart

Source sentences

In mice, liver thymosin beta‑4 wet weight concentration rose significantly from the first 40 min to 2 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the liver rose after injection compared with baseline.

Measurements

wet weight concentration

15 micrograms/g

liver after injection

wet weight concentration

9 micrograms/g

liver baseline

Source sentences

In mice, kidney thymosin beta‑4 wet weight concentration rose significantly from the first 40 min to 2 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the kidneys rose after injection compared with baseline.

Measurements

wet weight concentration

65 micrograms/g

kidneys after injection

wet weight concentration

28 micrograms/g

kidneys baseline

Source sentences

In mice, peritoneal fat thymosin beta‑4 wet weight concentration rose significantly from the first 40 min to 2 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in peritoneal fat rose after injection compared with baseline.

Measurements

wet weight concentration

47 micrograms/g

peritoneal fat after injection

wet weight concentration

13 micrograms/g

peritoneal fat baseline

Source sentences

In mice, thymus thymosin beta‑4 wet weight concentration rose 6 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the thymus rose six hours after injection compared with baseline.

Measurements

wet weight concentration

196 micrograms/g

thymus after injection

wet weight concentration

147 micrograms/g

thymus baseline

Source sentences

In mice, muscle thymosin beta‑4 wet weight concentration rose 6 h after injection versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in muscle rose six hours after injection compared with baseline.

Measurements

wet weight concentration

45 micrograms/g

muscle after injection

wet weight concentration

0 micrograms/g

muscle baseline

Source sentences

In mice, spleen thymosin beta‑4 wet weight concentration rose at the 2 min timepoint versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the spleen rose two minutes after injection compared with baseline.

Measurements

wet weight concentration

267 micrograms/g

spleen at 2 min

wet weight concentration

161 micrograms/g

spleen baseline

Source sentences

In mice, ovary thymosin beta‑4 concentration rose in two phases, at 40 min and at 24 h, versus baseline.

In plain wordsIn mice, thymosin beta‑4 levels in the ovaries rose in two phases after injection compared with baseline.

Measurements

wet weight concentration

72 micrograms/g

ovaries at 40 min

wet weight concentration

92 micrograms/g

ovaries at 24 h

wet weight concentration

62 micrograms/g

ovaries baseline

Source sentences

In mice, the highest lung thymosin beta‑4 wet weight concentration after injection was not higher than the baseline concentration.

In plain wordsIn mice, thymosin beta‑4 levels in the lungs did not rise above baseline after injection.

Measurements

wet weight concentration

149 micrograms/g

lungs at 6 h

wet weight concentration

153 micrograms/g

lungs baseline

Source sentences