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Study · Non-randomized trial · n = 20 · 1997

5 results

Hyperglycemia counterbalances the antihypertensive effect of glutathione in diabetic patients: evidence linking hypertension and glycemia through the oxidative stress in diabetes mellitus.

Cerielo A, Motz E, Cavarape A, Lizzio S, Russo A, Quatraro A, Giugliano D

Journal of diabetes and its complications1 Jul 1997Cited by 28 (Europe PMC)

PMID9201603 (opens in a new tab)DOI10.1016/s1056-8727(97)00021-4 (opens in a new tab)PepBankPUB-09201603
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In diabetic subjects, adding glutathione to glucose testing did not change plasma glucose variations compared with glucose testing alone.

    In plain wordsIn diabetic subjects, plasma glucose changes were similar with glutathione plus glucose testing and glucose testing alone.

    Peptide
    Glutathione
    Outcome
    No significant changePlasma glucose during glucose testing
    Study

    n = 20

    Comparator
    Glucose testing alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    1 g/m2 bolus + 1 g/m2 in 2 h · intravenous · 2 hAs given in this study (human).

    Source sentences

    Summary
    Variations in plasma glucose and insulin levels were not different during each test in the two groups of patients and in test (1) compared to (3).
    1 context sentence
    Summary · context
    In this study, three different tests were performed in ten hypertensive and ten nonhypertensive diabetic subjects: (1) an oral glucose tolerance test, (2) glutathione i.v. administration (1 g/m2 bolus + 1 g/m2 in 2 h), and (3) oral glucose tolerance test + glutathione administration.
  2. 02HumanNon-randomized trialEfficacy outcome

    In diabetic subjects, adding glutathione to glucose testing did not change insulin variations compared with glucose testing alone.

    In plain wordsIn diabetic subjects, insulin changes were similar with glutathione plus glucose testing and glucose testing alone.

    Peptide
    Glutathione
    Outcome
    No significant changePlasma insulin during glucose testing
    Study

    n = 20

    Comparator
    Glucose testing alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    1 g/m2 bolus + 1 g/m2 in 2 h · intravenous · 2 hAs given in this study (human).

    Source sentences

    Summary
    Variations in plasma glucose and insulin levels were not different during each test in the two groups of patients and in test (1) compared to (3).
    1 context sentence
    Summary · context
    In this study, three different tests were performed in ten hypertensive and ten nonhypertensive diabetic subjects: (1) an oral glucose tolerance test, (2) glutathione i.v. administration (1 g/m2 bolus + 1 g/m2 in 2 h), and (3) oral glucose tolerance test + glutathione administration.
  3. 03HumanNon-randomized trialEfficacy outcome

    In hypertensive and nonhypertensive diabetic subjects, glutathione reduced systolic blood pressure from 30' to 120'.

    In plain wordsIn diabetic subjects with or without hypertension, glutathione reduced systolic blood pressure from baseline.

    Peptide
    Glutathione
    Outcome
    DecreaseSystolic blood pressure
    Study

    n = 20

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 g/m2 bolus + 1 g/m2 in 2 h · intravenous · 2 hAs given in this study (human).

    Source sentences

    Summary
    Glutathione administration reduced systolic and diastolic blood pressure in both hypertensive and nonhypertensive diabetic subjects from 30' to 120'.
    1 context sentence
    Summary · context
    In this study, three different tests were performed in ten hypertensive and ten nonhypertensive diabetic subjects: (1) an oral glucose tolerance test, (2) glutathione i.v. administration (1 g/m2 bolus + 1 g/m2 in 2 h), and (3) oral glucose tolerance test + glutathione administration.
  4. 04HumanNon-randomized trialEfficacy outcome

    In hypertensive and nonhypertensive diabetic subjects, glutathione reduced diastolic blood pressure from 30' to 120'.

    In plain wordsIn diabetic subjects with or without hypertension, glutathione reduced diastolic blood pressure from baseline.

    Peptide
    Glutathione
    Outcome
    DecreaseDiastolic blood pressure
    Study

    n = 20

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 g/m2 bolus + 1 g/m2 in 2 h · intravenous · 2 hAs given in this study (human).

    Source sentences

    Summary
    Glutathione administration reduced systolic and diastolic blood pressure in both hypertensive and nonhypertensive diabetic subjects from 30' to 120'.
    1 context sentence
    Summary · context
    In this study, three different tests were performed in ten hypertensive and ten nonhypertensive diabetic subjects: (1) an oral glucose tolerance test, (2) glutathione i.v. administration (1 g/m2 bolus + 1 g/m2 in 2 h), and (3) oral glucose tolerance test + glutathione administration.
  5. 05HumanNon-randomized trialEfficacy outcome

    In diabetic subjects, the blood pressure reduction after intravenous glutathione was abolished as glycemia increased after oral glucose loading.

    In plain wordsIn diabetic subjects, the blood pressure drop seen with glutathione disappeared as blood glucose rose after oral glucose loading.

    Peptide
    Glutathione
    Outcome
    No significant changeLoss of hypotensive effect during glucose loading
    Study

    n = 20

    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    1 g/m2 bolus + 1 g/m2 in 2 h · intravenous · 2 hAs given in this study (human).

    Source sentences

    Summary
    This phenomenon was abolished as glycemia increased after oral glucose loading.
    2 context sentences
    Summary · context
    Glutathione administration reduced systolic and diastolic blood pressure in both hypertensive and nonhypertensive diabetic subjects from 30' to 120'.
    Summary · context
    In this study, three different tests were performed in ten hypertensive and ten nonhypertensive diabetic subjects: (1) an oral glucose tolerance test, (2) glutathione i.v. administration (1 g/m2 bolus + 1 g/m2 in 2 h), and (3) oral glucose tolerance test + glutathione administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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