Skip to content

Study · Randomized controlled trial · n = 6 · 1997

2 results

Non-parametric deconvolution provides an objective assessment of GH responsiveness to GH-releasing stimuli in normal subjects.

Sartorio A, De Nicolao G, Pizzini G, Liberati D

Clinical endocrinology1 Apr 1997Cited by 6 (Europe PMC)

PMID9196598 (opens in a new tab)DOI10.1046/j.1365-2265.1997.8770887.x (opens in a new tab)PepBankPUB-09196598
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialActivity measurement

    In healthy men, the GH secretion rate rose after the first hexarelin bolus, mostly within 60 minutes.

    In plain wordsIn healthy men, a hexarelin dose raised growth hormone release, mostly within the first hour.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH secretion rate after first hexarelin bolus
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg body weightAs given in this study (human).

    Source sentences

    Summary
    The analysis of the data showed a clear rise in the ISR subsequent to the first bolus (either GHRH or hexarelin), with most of the response occurring within 60 minutes of the stimulus.
    1 context sentence
    Summary · context
    Subjects of group II were tested, in random order, with a 4- or 5-day interval, with (1) two consecutive 1 microgram/kg body weight GHRH boluses at 0 and 120 minutes and (2) two consecutive 1 microgram/kg body weight hexarelin boluses, administered at 0 and 120 minutes.
  2. 02HumanRandomized controlled trialActivity measurement

    In healthy men, the amount of GH secreted after a second hexarelin bolus was reduced compared with the first.

    In plain wordsIn healthy men, a second hexarelin dose given two hours later released less growth hormone than the first.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH secreted after second hexarelin bolus
    Study

    n = 6

    Comparator
    First hexarelin bolus
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg body weightAs given in this study (human).

    Measurements

    GH after second bolus, share of total secreted
    13 to 36%
    hexarelin

    Source sentences

    Summary
    The amount of GH secreted after the second stimulus ranged from 13 to 36% (GHRH 17-36%; hexarelin 13-36%) of the overall amount of hormone secreted after time 0 minutes.
    2 context sentences
    Summary · context
    The analysis of GH responsiveness to repeated stimuli (group II) showed that the amount of hormone secreted after the second bolus was clearly reduced in comparison with the elicited by the first stimulus, most of the response occurring within 60 minutes of the injection.
    Summary · context
    Subjects of group II were tested, in random order, with a 4- or 5-day interval, with (1) two consecutive 1 microgram/kg body weight GHRH boluses at 0 and 120 minutes and (2) two consecutive 1 microgram/kg body weight hexarelin boluses, administered at 0 and 120 minutes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.