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Study · Animal study (in vivo) · 1997

5 results

Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.

Malinda KM, Goldstein AL, Kleinman HK

FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 May 1997Cited by 180 (Europe PMC)

PMID9194528 (opens in a new tab)DOI10.1096/fasebj.11.6.9194528 (opens in a new tab)PepBankPUB-09194528
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In subcutaneously implanted Matrigel, thymosin beta‑4 stimulated cell migration in vivo.

    In plain wordsIn an animal implant test, thymosin beta‑4 stimulated cell migration. The abstract does not name the species.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell migration into subcutaneously implanted Matrigel in vivo
    Study

    n: not reported in source

    Subcutaneously implanted Matrigel
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additional experiments using subcutaneously implanted Matrigel showed that T beta 4 stimulated cell migration in vivo.
    1 context sentence
    Summary · context
    Here we have used various in vitro and in vivo migration assays to demonstrate the role of T beta 4 in endothelial cell migration.
  2. 02LabIn vitro (cells)Activity measurement

    In human umbilical vein endothelial cells, thymosin beta‑4 raised migration in Boyden chambers four- to sixfold over media alone.

    In plain wordsIn cells, thymosin beta‑4 made human vein endothelial cells migrate four to six times more than media alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHUVEC migration in Boyden chambers
    Study

    humann: not reported in source

    HUVEC (Boyden chamber)
    Comparator
    Media alone
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our results demonstrate that T beta 4 acts as a chemoattractant for endothelial cells, stimulating the migration of HUVECs in Boyden chambers four- to sixfold over that observed with media alone.
    1 context sentence
    Summary · context
    Here we have used various in vitro and in vivo migration assays to demonstrate the role of T beta 4 in endothelial cell migration.
  3. 03LabIn vitro (cells)Activity measurement

    Among the primary cell types tested, only human coronary artery cells migrated in response to thymosin beta‑4.

    In plain wordsIn cells, of the primary cell types tested, only human coronary artery cells responded to thymosin beta‑4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedEndothelial specificity of migration response across primary cell types
    Study

    humann: not reported in source

    Primary cell types
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of the primary cell types tested, only human coronary artery cells responded to T beta 4 treatment, suggesting that the migration activity of T beta 4 was endothelial cell-specific.
    1 context sentence
    Summary · context
    Here we have used various in vitro and in vivo migration assays to demonstrate the role of T beta 4 in endothelial cell migration.
  4. 04LabIn vitro (cells)Activity measurement

    In scratch-wounded human umbilical vein endothelial cell monolayers, thymosin beta‑4 significantly accelerated the rate of migration into the wounded area.

    In plain wordsIn cells, thymosin beta‑4 sped up how fast vein endothelial cells moved into a scratched area.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseScratch-wound migration rate of HUVEC monolayer
    Study

    humann: not reported in source

    HUVEC monolayer (scratch wound)
    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T beta 4 significantly accelerated the rate of migration into the scratch wounded area of a HUVEC monolayer.
    1 context sentence
    Summary · context
    Here we have used various in vitro and in vivo migration assays to demonstrate the role of T beta 4 in endothelial cell migration.
  5. 05LabIn vitro (cells)Mechanism

    In endothelial cells, thymosin beta‑4 treatment increased the production of matrix metalloproteinases that may degrade the basement membrane during angiogenesis.

    In plain wordsIn cells, thymosin beta‑4 increased the production of enzymes that may break down the basement membrane.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMatrix metalloproteinase production
    Study

    humann: not reported in source

    Endothelial cells in culture
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T beta 4 treatment also increased the production of matrix metalloproteinases that may degrade the basement membrane during angiogenesis.
    1 context sentence
    Summary · context
    Here we have used various in vitro and in vivo migration assays to demonstrate the role of T beta 4 in endothelial cell migration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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