Effects of histaminergic antagonists on the GH-releasing activity of GHRH or hexarelin, a synthetic hexapeptide, in man.

Arvat E, Maccagno B, Ramunni J, Gianotti L, Di Vito L, Deghenghi R, Camanni F, Ghigo E

Journal of endocrinological investigation1 Mar 1997Cited by 9 (Europe PMC)

PMID9186817DOI10.1007/bf03346889PepBankPUB-09186817

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

5 results from studies that gave the peptide. 5 results from people.

01HumanNon-randomized trialActivity measurement
In young women, hexarelin raised the GH peak compared with baseline.
In plain wordsIn young women, hexarelin raised growth hormone levels compared with baseline.
Peptide
Hexarelin
Outcome
IncreaseGH peak after hexarelin
Study
n = 7
Comparator
Baseline
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH peak after hexarelin
49.1 micrograms/l
n=7
GH peak at baseline
3.9 micrograms/l
n=7
Source sentences
Summary
than that elicited by HEX (49.1 +/- 8.5 vs 3.9 +/- 1.0 micrograms/l, p < 0.01, n = 7; 48.7 +/- 8.9 vs 3.2 +/- 0.8 micrograms/l, p < 0.01, n = 6).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
Report a problemFND-0918681701
02HumanNon-randomized trialActivity measurement
In young women, the GH rise after hexarelin was higher than after GHRH.
In plain wordsIn young women, hexarelin released more growth hormone than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH peak, hexarelin vs GHRH
Study
n = 7
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Source sentences
Summary
GHRH induced a GH rise (peak, mean +/- SEM: 35.4 +/- 6.5 vs 2.5 +/- 1.1 micrograms/l, p < 0.02, n = 7; 34.7 +/- 7.9 vs 3.9 +/- 1.5 micrograms/l, p < 0.02, n = 6) lower (p < 0.05) than that elicited by HEX (49.1 +/- 8.5 vs 3.9 +/- 1.0 micrograms/l, p < 0.01, n = 7; 48.7 +/- 8.9 vs 3.2 +/- 0.8 microgr…
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
Report a problemFND-0918681702
03HumanNon-randomized trialActivity measurement
In young women, hexarelin increased prolactin levels.
In plain wordsIn young women, hexarelin raised prolactin levels.
Peptide
Hexarelin
Outcome
IncreaseProlactin rise after hexarelin
Study
n = 7
Comparator
Baseline
Outcome group
Pituitary hormones · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
PRL
13.9 micrograms/l
after hexarelin
PRL
6.5 micrograms/l
baseline
Source sentences
Summary
HEX also significantly increased PRL (13.9 +/- 3.1 vs 6.5 +/- 0.8 micrograms/l, p < 0.03), ACTH (31.1 +/- 6.6 vs 16.6 +/- 2.9 pg/ml, p < 0.02) and cortisol (96.6 +/- 6.3 vs 82.2 +/- 6.2 micrograms/L, p < 0.05) levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
Report a problemFND-0918681703
04HumanNon-randomized trialActivity measurement
In young women, hexarelin increased ACTH levels.
In plain wordsIn young women, hexarelin raised ACTH levels.
Peptide
Hexarelin
Outcome
IncreaseACTH rise after hexarelin
Study
n = 7
Comparator
Baseline
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
ACTH
31.1 pg/ml
after hexarelin
ACTH
16.6 pg/ml
baseline
Source sentences
Summary
HEX also significantly increased PRL (13.9 +/- 3.1 vs 6.5 +/- 0.8 micrograms/l, p < 0.03), ACTH (31.1 +/- 6.6 vs 16.6 +/- 2.9 pg/ml, p < 0.02) and cortisol (96.6 +/- 6.3 vs 82.2 +/- 6.2 micrograms/L, p < 0.05) levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
Report a problemFND-0918681704
05HumanNon-randomized trialActivity measurement
In young women, hexarelin increased cortisol levels.
In plain wordsIn young women, hexarelin raised cortisol levels.
Peptide
Hexarelin
Outcome
IncreaseCortisol rise after hexarelin
Study
n = 7
Comparator
Baseline
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
Cortisol
96.6 micrograms/L
after hexarelin
Cortisol
82.2 micrograms/L
baseline
Source sentences
Summary
HEX also significantly increased PRL (13.9 +/- 3.1 vs 6.5 +/- 0.8 micrograms/l, p < 0.03), ACTH (31.1 +/- 6.6 vs 16.6 +/- 2.9 pg/ml, p < 0.02) and cortisol (96.6 +/- 6.3 vs 82.2 +/- 6.2 micrograms/L, p < 0.05) levels.
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
Report a problemFND-0918681705

Studies that did not test the peptide alone5

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

06HumanNot a test of Hexarelin aloneNon-randomized trialMechanism
In young women, diphenhydramine reduced the GH response to hexarelin, which was used as a stimulus.
In plain wordsIn young women, the antihistamine diphenhydramine lowered the growth hormone response to hexarelin.
Peptide
Hexarelin
Outcome
DecreaseDiphenhydramine effect on hexarelin-induced GH response
Study
n = 7
Comparator
Hexarelin without diphenhydramine
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC with diphenhydramine
922 micrograms*min/l
hexarelin
GH AUC without diphenhydramine
1636.4 micrograms*min/l
hexarelin
Source sentences
Summary
and HEX (922.0 +/- 215.4 vs 1636.4 +/- 267.5 micrograms*min/l, p < 0.05), although the HEX-induced GH rise persisted higher than that induced by GHRH (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0918681706
07HumanNot a test of Hexarelin aloneNon-randomized trialMechanism
In young women, diphenhydramine and terfenadine did not change the prolactin response to hexarelin.
In plain wordsIn young women, antihistamines did not change the prolactin response to hexarelin.
Peptide
Hexarelin
Outcome
No significant changeAntihistamine effect on hexarelin-induced prolactin release
Study
n = 7
Comparator
Hexarelin without antihistamine
Outcome group
Pituitary hormones · Endocrine and hormones
Source sentences
Summary
PRL, ACTH and cortisol responses to HEX were unaffected by DPH (536.5 +/- 85.6 vs 599.5 +/- 129.2 micrograms*min/l, 1068.5 +/- 306.0 vs 1282.8 +/- 222.0 pg*min/ml and 4277.4 +/- 588.4 vs 4738.3 +/- 355.3 micrograms*min/l, respectively) as well as by TRF
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0918681708
08HumanNot a test of Hexarelin aloneNon-randomized trialMechanism
In young women, diphenhydramine and terfenadine did not change the ACTH response to hexarelin.
In plain wordsIn young women, antihistamines did not change the ACTH response to hexarelin.
Peptide
Hexarelin
Outcome
No significant changeAntihistamine effect on hexarelin-induced ACTH release
Study
n = 7
Comparator
Hexarelin without antihistamine
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
PRL, ACTH and cortisol responses to HEX were unaffected by DPH (536.5 +/- 85.6 vs 599.5 +/- 129.2 micrograms*min/l, 1068.5 +/- 306.0 vs 1282.8 +/- 222.0 pg*min/ml and 4277.4 +/- 588.4 vs 4738.3 +/- 355.3 micrograms*min/l, respectively) as well as by TRF
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0918681709
09HumanNot a test of Hexarelin aloneNon-randomized trialMechanism
In young women, diphenhydramine and terfenadine did not change the cortisol response to hexarelin.
In plain wordsIn young women, antihistamines did not change the cortisol response to hexarelin.
Peptide
Hexarelin
Outcome
No significant changeAntihistamine effect on hexarelin-induced cortisol release
Study
n = 7
Comparator
Hexarelin without antihistamine
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
PRL, ACTH and cortisol responses to HEX were unaffected by DPH (536.5 +/- 85.6 vs 599.5 +/- 129.2 micrograms*min/l, 1068.5 +/- 306.0 vs 1282.8 +/- 222.0 pg*min/ml and 4277.4 +/- 588.4 vs 4738.3 +/- 355.3 micrograms*min/l, respectively) as well as by TRF
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0918681710
10HumanNot a test of Hexarelin aloneNon-randomized trialMechanism
In young women, terfenadine did not change the GH response to hexarelin, which was used as a stimulus.
In plain wordsIn young women, the antihistamine terfenadine did not change the growth hormone response to hexarelin.
Peptide
Hexarelin
Outcome
No significant changeTerfenadine effect on hexarelin-induced GH response
Study
n = 6
Comparator
Hexarelin without terfenadine
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC with terfenadine
1163.2 mg*min/l
hexarelin
GH AUC without terfenadine
1427.3 mg*min/l
hexarelin
Source sentences
Summary
as well as the somatotrope responsiveness to HEX (1163.2 +/- 188.7 vs 1427.3 +/- 323.3 mg*min/l).
1 context sentence(design, population, supporting numbers)
Summary · context
To clarify this point, in 7 normal young women (23-28 yr) in their early follicular phase, we studied the effect of the histaminergic blockade by diphenhydramine (DPH, 80 mg os at -60 min) on the GH response to GHRH (2 micrograms/Hg iv) or Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide…
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0918681707

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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