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Study · Non-randomized trial · n = 38 · 1997

3 results

Oestrogen replacement does not restore the reduced GH-releasing activity of Hexarelin, a synthetic hexapeptide, in post-menopausal women.

Arvat E, Gianotti L, Broglio F, Maccagno B, Bertagna A, Deghenghi R, Camanni F, Ghigo E

European journal of endocrinology1 May 1997Cited by 21 (Europe PMC)

PMID9186268 (opens in a new tab)DOI10.1530/eje.0.1360483 (opens in a new tab)PepBankPUB-09186268
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In post-menopausal women, the GH response to hexarelin (area under the curve) was lower than in young women.

    In plain wordsIn post-menopausal women, hexarelin released less growth hormone than in young women.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin, post-menopausal vs young women
    Study

    n = 38

    Comparator
    Young women
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH AUC
    453.6 micrograms.min/l
    post-menopausal women
    GH AUC
    1630.4 micrograms.min/l
    young women

    Source sentences

    Summary
    The GH response to HEX in PW (areas under the curve +/- S.E.M.: 453.6 +/- 56.0 micrograms.min/l) was lower (P < 0.002) than that in YW (1630.4 +/- 259.7 micrograms.min/l) while it did not differ from that in AW (781.8 +/- 189.3 micrograms.min/l).
    1 context sentence
    Summary · context
    We studied the GH response to the acute administration of the maximal effective dose of HEX (2 micrograms/kg i.v.) in 24 young women (YW, age: 27.3 +/- 0.5 years: body mass index (BMI): 20.7 +/- 0.3 kg/m2), 14 post-menopausal women (PW, age: 52.9 +/- 1.2 years: BMI: 23.2 +/- 0.9 kg/m2) and 14 aged w…
  2. 02HumanNon-randomized trialActivity measurement

    In post-menopausal women, the GH response to hexarelin did not differ from that in aged women.

    In plain wordsPost-menopausal women and aged women had a similar growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin, post-menopausal vs aged women
    Study

    n = 28

    Comparator
    Aged women
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH AUC
    453.6 micrograms.min/l
    post-menopausal women
    GH AUC
    781.8 micrograms.min/l
    aged women

    Source sentences

    Summary
    The GH response to HEX in PW (areas under the curve +/- S.E.M.: 453.6 +/- 56.0 micrograms.min/l) was lower (P < 0.002) than that in YW (1630.4 +/- 259.7 micrograms.min/l) while it did not differ from that in AW (781.8 +/- 189.3 micrograms.min/l).
    1 context sentence
    Summary · context
    We studied the GH response to the acute administration of the maximal effective dose of HEX (2 micrograms/kg i.v.) in 24 young women (YW, age: 27.3 +/- 0.5 years: body mass index (BMI): 20.7 +/- 0.3 kg/m2), 14 post-menopausal women (PW, age: 52.9 +/- 1.2 years: BMI: 23.2 +/- 0.9 kg/m2) and 14 aged w…
  3. 03HumanNon-randomized trialActivity measurement

    In post-menopausal women, 3 months of transdermal oestradiol did not change the GH response to hexarelin.

    In plain wordsIn post-menopausal women, three months of oestradiol did not change how much growth hormone hexarelin released.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin after 3 months of oestradiol
    Study

    n = 10

    Comparator
    Before oestradiol treatment
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH AUC
    518.4 micrograms.min/l
    after oestradiol
    GH AUC
    425.4 micrograms.min/l
    before oestradiol

    Source sentences

    Summary
    Also the GH response to HEX was not modified by oestradiol treatment (518.4 +/- 125.6 vs 425.4 +/- 69.3 micrograms.min/l).
    1 context sentence
    Summary · context
    In 10 post-menopausal women the GH response to HEX was also studied after 3 months of transdermal oestradiol treatment (delivery 50 micrograms/die).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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