Gonadotrophin-releasing hormone agonist therapy for hirsutism is as effective as high dose cyproterone acetate but results in a longer remission.

Carmina E, Lobo RA

Human reproduction (Oxford, England)1 Apr 1997Cited by 21 (Europe PMC)

PMID9159420DOI10.1093/humrep/12.4.663PepBankPUB-09159420

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In hyperandrogenic women, triptorelin with add-back hormones reduced hirsutism more than the Diane regimen after one year.
In plain wordsIn hyperandrogenic women, triptorelin with add-back hormones reduced hair growth more than the Diane regimen after one year.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHirsutism reduction
Study
n: not reported in source
Comparator
Diane: cyproterone acetate plus ethinylestradiol
Outcome group
Skin and hair · Reproductive and sexual health
Source sentences
Summary
After one year of treatment, hirsutism decreased in all groups but the changes were greater (P <0.05) in the CPA and GnRHa groups than in the Diane group.
2 context sentences(design, population, supporting numbers)
Summary · context
or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group).
Summary · context
All women were treated for 1 year with 1 year follow-up.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0915942001
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In hyperandrogenic women, serum LH was lowest with triptorelin plus add-back hormones among the treatment groups.
In plain wordsIn hyperandrogenic women, LH was lowest with triptorelin plus add-back hormones among the treatment groups.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum LH during treatment
Study
n: not reported in source
Comparator
Diane and high-dose cyproterone acetate regimens
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Serum LH and testosterone were lowest in the GnRHa group.
2 context sentences(design, population, supporting numbers)
Summary · context
or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group).
Summary · context
All women were treated for 1 year with 1 year follow-up.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0915942002
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In hyperandrogenic women, testosterone was lowest with triptorelin plus add-back hormones among the treatment groups.
In plain wordsIn hyperandrogenic women, testosterone was lowest with triptorelin plus add-back hormones among the treatment groups.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum testosterone during treatment
Study
n: not reported in source
Comparator
Diane and high-dose cyproterone acetate regimens
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Serum LH and testosterone were lowest in the GnRHa group.
2 context sentences(design, population, supporting numbers)
Summary · context
or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group).
Summary · context
All women were treated for 1 year with 1 year follow-up.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0915942003
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In hyperandrogenic women, hirsutism returned more gradually after triptorelin plus add-back hormones than after the comparator regimens.
In plain wordsIn hyperandrogenic women, hair growth returned more gradually after triptorelin plus add-back hormones than after the comparator regimens.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHirsutism recurrence rate after withdrawal
Study
n: not reported in source
Comparator
Diane and high-dose cyproterone acetate regimens
Outcome group
Skin and hair · Reproductive and sexual health
Source sentences
Summary
In the GnRHa group, hirsutism increased more gradually and after 1 year of withdrawal, FGL scores and hair diameters were significantly (P <0.05) less than pretreatment values.
3 context sentences(design, population, supporting numbers)
Summary · context
After withdrawal, hirsutism increased rapidly in the Diane and CPA groups and after 6 months, FGL scores and hair shaft diameters were similar to pretreatment values.
Summary · context
or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group).
Summary · context
All women were treated for 1 year with 1 year follow-up.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0915942004
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In hyperandrogenic women, FGL scores remained below pretreatment values one year after withdrawal of triptorelin plus add-back hormones.
In plain wordsIn hyperandrogenic women, hair growth scores remained below pretreatment values one year after withdrawal of triptorelin plus add-back hormones.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFGL score after withdrawal
Study
n: not reported in source
Comparator
Pretreatment
Outcome group
Skin and hair · Reproductive and sexual health
Source sentences
Summary
In the GnRHa group, hirsutism increased more gradually and after 1 year of withdrawal, FGL scores and hair diameters were significantly (P <0.05) less than pretreatment values.
2 context sentences(design, population, supporting numbers)
Summary · context
or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group).
Summary · context
All women were treated for 1 year with 1 year follow-up.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0915942005
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In hyperandrogenic women, hair diameters remained below pretreatment values one year after withdrawal of triptorelin plus add-back hormones.
In plain wordsIn hyperandrogenic women, hair diameters remained below pretreatment values one year after withdrawal of triptorelin plus add-back hormones.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHair shaft diameter after withdrawal
Study
n: not reported in source
Comparator
Pretreatment
Outcome group
Skin and hair · Reproductive and sexual health
Source sentences
Summary
In the GnRHa group, hirsutism increased more gradually and after 1 year of withdrawal, FGL scores and hair diameters were significantly (P <0.05) less than pretreatment values.
2 context sentences(design, population, supporting numbers)
Summary · context
or Decapeptyl 3.75 mg i.m. every 28 days with the addition of conjugated oestrogen 0.625 mg, days 1-21, and medroxyprogesterone acetate 10 mg, days 12-21 (GnRHa group).
Summary · context
All women were treated for 1 year with 1 year follow-up.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0915942006

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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