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Study · Randomized controlled trial · n = 8 · 1997

3 results

Acute administration of hexarelin stimulates GH secretion during day and night in normal men.

Loche S, Colao A, Cappa M, Ferone D, Merola B, Faedda A, Imbimbo BP, Deghenghi R, Lombardi G

Clinical endocrinology1 Mar 1997Cited by 1 (Europe PMC)

PMID9156035 (opens in a new tab)DOI10.1046/j.1365-2265.1997.1240940.x (opens in a new tab)PepBankPUB-09156035
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In eight normal men, mean peak GH after hexarelin during sleep (61.2 micrograms/l) did not differ from that in the morning (58.2 micrograms/l).

    In plain wordsIn healthy men, hexarelin raised growth hormone to a similar peak at night during sleep and in the morning.

    Peptide
    Hexarelin
    Outcome
    No significant changePeak GH after hexarelin, sleep versus morning
    Study

    n = 8

    Comparator
    Hexarelin during morning wakefulness
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · single injectionAs given in this study (human).

    Measurements

    Peak GH
    61.2 micrograms/l
    sleep
    Peak GH
    58.2 micrograms/l
    morning

    Source sentences

    Summary
    Mean peak GH concentrations after hexarelin during the morning (58.2 +/- 4.7 micrograms/l) (GH micrograms/l l x 2 = mU/l) were not different from those observed during sleep (61.2 +/- 4.3 micrograms/l).
    2 context sentences
    Summary · context
    Eight normal men, aged 21-33 years, of normal height and within 10% of ideal body weight were studied.
    Summary · context
    All subjects received in random order saline or hexarelin (2 micrograms/kg) in the morning between 0800 and 0900 h after they had fasted overnight.
  2. 02HumanRandomized controlled trialOther

    In eight normal men, after hexarelin, GH disappeared from plasma more slowly during sleep (t1/2 64.9 min) than in the morning (t1/2 24.9 min, P < 0.01).

    In plain wordsIn healthy men, growth hormone cleared more slowly from the blood during sleep than in the morning after hexarelin.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH half-life after hexarelin, sleep versus morning
    Study

    n = 8

    Comparator
    Hexarelin during morning wakefulness
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · single injectionAs given in this study (human).

    Measurements

    GH half-life
    64.9 min
    sleep
    GH half-life
    24.9 min
    morning

    Source sentences

    Summary
    The rate of disappearance of GH from plasma was slower during sleep (t1/2 = 64.9 +/- 14.8 min) than during morning hours (t1/2 = 24.9 +/- 1.4 min, P < 0.01).
    2 context sentences
    Summary · context
    Eight normal men, aged 21-33 years, of normal height and within 10% of ideal body weight were studied.
    Summary · context
    All subjects received in random order saline or hexarelin (2 micrograms/kg) in the morning between 0800 and 0900 h after they had fasted overnight.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In eight normal men, the mean AUC response to hexarelin was higher during sleep than in the morning (P < 0.001).

    In plain wordsIn healthy men, the total growth hormone response to hexarelin was larger during sleep than in the morning.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH AUC after hexarelin, sleep versus morning
    Study

    n = 8

    Comparator
    Hexarelin during morning wakefulness
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · single injectionAs given in this study (human).

    Measurements

    GH AUC
    1466 micrograms.min/l
    sleep
    GH AUC
    903 micrograms.min/l
    morning

    Source sentences

    Summary
    Mean AUC responses to hexarelin during sleep (1466 +/- 145 micrograms.min/l) were significantly higher than during morning hours (903 +/- 94 micrograms.min/l, P < 0.001).
    2 context sentences
    Summary · context
    Eight normal men, aged 21-33 years, of normal height and within 10% of ideal body weight were studied.
    Summary · context
    All subjects received in random order saline or hexarelin (2 micrograms/kg) in the morning between 0800 and 0900 h after they had fasted overnight.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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