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Study · Animal study (in vivo) · rat · 1997

3 results

Pentadecapeptide BPC 157, cimetidine, ranitidine, bromocriptine, and atropine effect in cysteamine lesions in totally gastrectromized rats: a model for cytoprotective studies.

Sikirić P, Mikus D, Seiwerth S, Grabarević Z, Rucman R, Petek M, Jagić V, Turković B, Rotkvić I, Mise S, Zoricić I, Perić J and 11 more

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Konjevoda P, Perović D, Jurina L, Hanzevacki M, Separović J, Gjurasin M, Jadrijević S, Jelovac N, Miklić P, Buljat G, Marović A

Digestive diseases and sciences1 May 1997Cited by 33 (Europe PMC)

PMID9149058 (opens in a new tab)DOI10.1023/a:1018893220943 (opens in a new tab)PepBankPUB-09149058
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In totally gastrectomized rats, BPC‑157 given before cysteamine significantly prevented severe duodenal lesions seen in control rats.

    In plain wordsIn rats without a stomach, BPC‑157 given before cysteamine prevented the severe duodenal lesions seen in control rats.

    Peptide
    BPC-157
    Outcome
    DecreaseDuodenal lesions after cysteamine in gastrectomized rats
    Study

    ratn: not reported in source

    Total gastrectomy plus cysteamine
    Comparator
    Gastrectomized cysteamine controls
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Interestingly, in gastrectomized animals, the application of BPC 157 or the reference agents before cysteamine significantly prevented the otherwise severe duodenal lesion development noted in the control gastrectomized cysteamine rats.
    1 context sentence
    Summary · context
    In the absence of stomach and gastric acid, the damaging effects of cysteamine (400 mg/kg subcutaneously, death 24 hr thereafter), to date thought to be an acid-related duodenal ulcerogen, and the BPC 157 cytoprotective effect (10 microg or 10 ng/kg intraperitoneally)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In naive rats with an intact stomach, BPC‑157 had a strong beneficial effect against cysteamine lesions.

    In plain wordsIn rats with an intact stomach, BPC‑157 had a strong protective effect against cysteamine lesions.

    Peptide
    BPC-157
    Outcome
    DecreaseCysteamine lesions in rats with intact stomach
    Study

    ratn: not reported in source

    Naive rats with intact stomach plus cysteamine
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In naive rats, with intact stomach, all of them showed a strong beneficial effect.
    1 context sentence
    Summary · context
    BPC 157 was compared with reference agents [cimetidine (50), ranitidine (10), omeprazole (10), bromocriptine (10) and atropine (10) (mg/kg intraperitoneally, 1 hr before cysteamine
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In gastrectomized rats and rats with an intact stomach, BPC‑157 gave equal protection against cysteamine damage as the reference agents.

    In plain wordsIn rats with and without a stomach, BPC‑157 protected as much as reference drugs against cysteamine damage.

    Peptide
    BPC-157
    Outcome
    No significant changeProtection relative to reference agents
    Study

    ratn: not reported in source

    Gastrectomized and intact-stomach rats plus cysteamine
    Comparator
    Cimetidine, ranitidine, omeprazole, bromocriptine, atropine
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 microg or 10 ng/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    equal damaging effect of cysteamine and equal protection of pentadecapeptide BPC 157 and reference agents in gastrectomized and rats with intact stomach
    1 context sentence
    Summary · context
    BPC 157 was compared with reference agents [cimetidine (50), ranitidine (10), omeprazole (10), bromocriptine (10) and atropine (10) (mg/kg intraperitoneally, 1 hr before cysteamine

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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