In four individuals, continuous glucagon during basal and hyperinsulinemic periods increased hepatic glucose production suppression versus basal-period glucagon alone: 63 versus 52%.
In plain wordsIn four individuals, continuous glucagon increased suppression of liver glucose production compared with glucagon during the basal period only.
- Peptide
- Glucagon
- Outcome
- IncreaseSuppression of hepatic glucose production
- Study
n = 4
- Comparator
- Glucagon during the basal period only
- Outcome group
- Glycemic control · Metabolic and weight
- Studied dose
- Dose not stated
Measurements
- HGP suppression
- 63%
- continuous glucagon; +/- 3
- HGP suppression
- 52%
- basal-period glucagon; +/- 3
- P value
- 0.02
- comparison
Source sentences
in four additional individuals HGP was suppressed to a greater extent during a tolbutamide infusion when glucagon was administered continuously throughout the basal and hyperinsulinemic periods than when glucagon was infused during the basal period only; HGP suppressed by 63 +/- 3 vs. 52 +/- 3%, res…
1 context sentence(design, population, supporting numbers)
To further examine whether glucagon was enhancing the effect of portal insulin, in four additional individuals HGP was suppressed to a greater extent during a tolbutamide infusion when glucagon was administered continuously throughout the basal and hyperinsulinemic periods than when glucagon was inf…