Gonadotropin-releasing hormone analog plus an oral contraceptive containing desogestrel in women with severe hirsutism: effects on hair, bone, and hormone profile after 1-year use.

Castelo-Branco C, Martínez de Osaba MJ, Pons F, Fortuny A

Metabolism: clinical and experimental1 Apr 1997Cited by 19 (Europe PMC)

PMID9109850DOI10.1016/s0026-0495(97)90062-7PepBankPUB-09109850

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In severe hirsutism, triptorelin plus oral contraceptive reduced hirsutism similarly to ethinyl-estradiol plus cyproterone acetate.
In plain wordsIn severe hirsutism, triptorelin plus oral contraceptive reduced hair growth similarly to ethinyl-estradiol plus cyproterone acetate.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeHirsutism reduction
Study
n = 48
Comparator
Ethinyl-estradiol plus cyproterone acetate
Outcome group
Skin and hair · Reproductive and sexual health
Measurements
Hirsutism reduction
41.9%
triptorelin plus oral contraceptive
Hirsutism reduction
40.5%
comparator
Source sentences
Summary
After 1 year of follow-up study, the combination of a GnRHa plus OC resulted in a decrease of hirsutism similar to that observed in the CPA group (41.9% v 40.5%) and in a suppression of gonadotropins and ovarian steroids in all treated women, without significant changes in bone density.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-three patients received 3.75 mg D-Trp-6-LHRH intramuscularly monthly for 1 year plus an OC containing 30 micrograms ethinyl-estradiol and 150 micrograms desogestrel.
Summary · context
A second group of 25 subjects received an OC containing 35 micrograms ethinyl-estradiol and 2 mg cyproterone acetate (CPA).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0910985001
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In women with severe hirsutism, triptorelin plus oral contraceptive suppressed gonadotropins during treatment.
In plain wordsIn women with severe hirsutism, triptorelin plus oral contraceptive suppressed gonadotropins during treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseGonadotropin suppression
Study
n = 23
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
After 1 year of follow-up study, the combination of a GnRHa plus OC resulted in a decrease of hirsutism similar to that observed in the CPA group (41.9% v 40.5%) and in a suppression of gonadotropins and ovarian steroids in all treated women, without significant changes in bone density.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-three patients received 3.75 mg D-Trp-6-LHRH intramuscularly monthly for 1 year plus an OC containing 30 micrograms ethinyl-estradiol and 150 micrograms desogestrel.
Summary · context
A second group of 25 subjects received an OC containing 35 micrograms ethinyl-estradiol and 2 mg cyproterone acetate (CPA).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0910985002
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In women with severe hirsutism, triptorelin plus oral contraceptive suppressed ovarian steroids during treatment.
In plain wordsIn women with severe hirsutism, triptorelin plus oral contraceptive suppressed ovarian steroids during treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOvarian steroid suppression
Study
n = 23
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
After 1 year of follow-up study, the combination of a GnRHa plus OC resulted in a decrease of hirsutism similar to that observed in the CPA group (41.9% v 40.5%) and in a suppression of gonadotropins and ovarian steroids in all treated women, without significant changes in bone density.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-three patients received 3.75 mg D-Trp-6-LHRH intramuscularly monthly for 1 year plus an OC containing 30 micrograms ethinyl-estradiol and 150 micrograms desogestrel.
Summary · context
A second group of 25 subjects received an OC containing 35 micrograms ethinyl-estradiol and 2 mg cyproterone acetate (CPA).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0910985003
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialSafety outcome
In women with severe hirsutism, bone density did not change significantly during triptorelin plus oral contraceptive treatment.
In plain wordsIn women with severe hirsutism, bone density did not change significantly during triptorelin plus oral contraceptive treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeBone mineral density
Study
n = 23
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
After 1 year of follow-up study, the combination of a GnRHa plus OC resulted in a decrease of hirsutism similar to that observed in the CPA group (41.9% v 40.5%) and in a suppression of gonadotropins and ovarian steroids in all treated women, without significant changes in bone density.
2 context sentences(design, population, supporting numbers)
Summary · context
Twenty-three patients received 3.75 mg D-Trp-6-LHRH intramuscularly monthly for 1 year plus an OC containing 30 micrograms ethinyl-estradiol and 150 micrograms desogestrel.
Summary · context
A second group of 25 subjects received an OC containing 35 micrograms ethinyl-estradiol and 2 mg cyproterone acetate (CPA).
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0910985004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.