Pentadecapeptide BPC 157 interactions with adrenergic and dopaminergic systems in mucosal protection in stress.

Sikirić P, Mazul B, Seiwerth S, Grabarević Z, Rucman R, Petek M, Jagić V, Turković B, Rotkvić I, Mise S, Zoricić I, Jurina L and 10 more

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Konjevoda P, Hanzevacki M, Gjurasin M, Separović J, Ljubanović D, Artuković B, Bratulić M, Tisljar M, Miklić P, Sumajstorcić J

Digestive diseases and sciences1 Mar 1997Cited by 10 (Europe PMC)

PMID9073154DOI10.1023/a:1018880000644PepBankPUB-09073154

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In animals under 48 h restraint stress, BPC‑157 given intragastrically or intraperitoneally gave strong protection against gastric lesions.
In plain wordsIn animals under stress, BPC‑157 strongly protected the stomach lining from lesions.
Peptide
BPC-157
Outcome
DecreaseGastroprotection in restraint stress
Study
n: not reported in source
48 h restraint stress
Comparator
Saline
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 microg or 10 ng/kg body wt · intraperitoneal or intragastricAs given in this study.
Source sentences
Summary
A strong protection, noted following intragastric or intraperitoneal administration of BPC 157
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were pretreated (1 hr before stress) with saline (controls) or BPC 157 (dissolved in saline) (10 microg or 10 ng/kg body wt intraperitoneally or intragastrically)
Report a problemFND-0907315401

Studies that did not test the peptide alone4

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

02AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Mechanism
In animals under 48 h restraint stress, coadministration of phentolamine, clonidine or haloperidol fully abolished the gastroprotection of BPC‑157.
In plain wordsIn animals under stress, three receptor-acting drugs given with BPC‑157 fully removed its stomach protection.
Peptide
BPC-157
Outcome
DecreaseBPC 157 protection with alpha-adrenergic or dopamine antagonist or agonist (phentolamine, clonidine, haloperidol)
Study
n: not reported in source
48 h restraint stress
Comparator
BPC 157 alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Source sentences
Summary
was fully abolished by coadministration of phentolamine, clonidine, and haloperidol
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were pretreated (1 hr before stress) with saline (controls) or BPC 157 (dissolved in saline) (10 microg or 10 ng/kg body wt intraperitoneally or intragastrically)
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-0907315402
03AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Mechanism
In animals under 48 h restraint stress, prazosin, yohimbine and domperidone did not affect the gastroprotection of BPC‑157.
In plain wordsIn animals under stress, prazosin, yohimbine and domperidone did not change how well BPC‑157 protected the stomach.
Peptide
BPC-157
Outcome
No significant changeBPC 157 protection with prazosin, yohimbine or domperidone
Study
n: not reported in source
48 h restraint stress
Comparator
BPC 157 alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Source sentences
Summary
consistently not affected by prazosin, yohimbine, or domperidone.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were pretreated (1 hr before stress) with saline (controls) or BPC 157 (dissolved in saline) (10 microg or 10 ng/kg body wt intraperitoneally or intragastrically)
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-0907315403
04AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Mechanism
In animals under 48 h restraint stress, atenolol abolished the gastroprotection of intraperitoneal BPC‑157 only.
In plain wordsIn animals under stress, atenolol removed the stomach protection of BPC‑157 given into the abdomen, but only for that route.
Peptide
BPC-157
Outcome
DecreaseIntraperitoneal BPC 157 protection with atenolol
Study
n: not reported in source
48 h restraint stress
Comparator
BPC 157 alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Source sentences
Summary
Atenolol abolished only intraperitoneal BPC 157 protection, whereas propranolol affected specifically intragastric BPC 157 protection.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were pretreated (1 hr before stress) with saline (controls) or BPC 157 (dissolved in saline) (10 microg or 10 ng/kg body wt intraperitoneally or intragastrically)
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-0907315404
05AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Mechanism
In animals under 48 h restraint stress, propranolol specifically affected the gastroprotection of intragastric BPC‑157.
In plain wordsIn animals under stress, propranolol changed the stomach protection of BPC‑157 given into the stomach, but not given into the abdomen.
Peptide
BPC-157
Outcome
DecreaseIntragastric BPC 157 protection with propranolol
Study
n: not reported in source
48 h restraint stress
Comparator
BPC 157 alone
Outcome group
Receptor activity and mechanism · Gastrointestinal
Source sentences
Summary
whereas propranolol affected specifically intragastric BPC 157 protection.
1 context sentence(design, population, supporting numbers)
Summary · context
Animals were pretreated (1 hr before stress) with saline (controls) or BPC 157 (dissolved in saline) (10 microg or 10 ng/kg body wt intraperitoneally or intragastrically)
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-0907315405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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