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Study · Animal study (in vivo) · wistar rat · 1997

3 results

Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats.

Kalogjera L, Ries M, Baudoin T, Ferencic Z, Trotic R, Pegan B

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery1 Jan 1997Cited by 17 (Europe PMC)

PMID9065615 (opens in a new tab)DOI10.1007/bf02439711 (opens in a new tab)PepBankPUB-09065615
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with capsaicin-induced rhinitis, BPC‑157 pretreatment significantly prevented mastocyte infiltration at 1 h.

    In plain wordsIn rats, BPC‑157 given beforehand prevented mast cell build-up in the nose after capsaicin.

    Peptide
    BPC-157
    Outcome
    DecreaseMastocyte infiltration at 1 h
    Study

    Wistar ratn: not reported in source

    capsaicin-induced rhinitis
    Comparator
    Saline
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal · single pretreatmentAs given in this study (Wistar rat).

    Source sentences

    Summary
    BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h.
    2 context sentences
    Summary · context
    Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally.
    Summary · context
    Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with capsaicin-induced rhinitis, BPC‑157 at 10 µg/kg significantly reduced polymorphonuclear leukocyte infiltration.

    In plain wordsIn rats, BPC‑157 at the higher dose reduced white blood cell build-up in the nose after capsaicin.

    Peptide
    BPC-157
    Outcome
    DecreasePolymorphonuclear leukocyte infiltration at 10 µg/kg
    Study

    Wistar ratn: not reported in source

    capsaicin-induced rhinitis
    Comparator
    Saline
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µg/kg · intraperitoneal · single pretreatmentAs given in this study (Wistar rat).

    Source sentences

    Summary
    Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 microg/kg BPC 157.
    2 context sentences
    Summary · context
    Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally.
    Summary · context
    Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with capsaicin-induced rhinitis, BPC‑157 pretreatment showed a dose-dependent effect on polymorphonuclear leukocyte infiltration at 12 h.

    In plain wordsIn rats, the effect of BPC‑157 on white blood cell build-up in the nose at 12 hours depended on the dose.

    Peptide
    BPC-157
    Outcome
    DecreaseDose-dependence of polymorphonuclear leukocyte infiltration at 12 h
    Study

    Wistar ratn: not reported in source

    capsaicin-induced rhinitis
    Comparator
    Saline
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal · single pretreatmentAs given in this study (Wistar rat).

    Source sentences

    Summary
    A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.
    2 context sentences
    Title · context
    Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats.
    Summary · context
    Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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