Somatotrope responsiveness to Hexarelin, a synthetic hexapeptide, is refractory to the inhibitory effect of glucose in obesity.

Grottoli S, Maccario M, Procopio M, Oleandri SE, Arvat E, Gianotti L, Deghenghi R, Camanni F, Ghigo E

European journal of endocrinology1 Dec 1996Cited by 8 (Europe PMC)

PMID9025712DOI10.1530/eje.0.1350678PepBankPUB-09025712

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

3 results from studies that gave the peptide. 3 results from people.

01HumanObservational studyActivity measurement
In obese men, the GH response to hexarelin was lower than in normal subjects (p < 0.0002).
In plain wordsObese men had a smaller growth hormone response to hexarelin than normal-weight men.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin, obese vs normal subjects
Study
n = 14
Comparator
Normal subjects
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenous · single doseAs given in this study (human).
Measurements
GH peak
20 micrograms/l
obese
GH peak
62.6 micrograms/l
normal subjects
Source sentences
Summary
Hexarelin induced a clear GH rise in OB (peak: 20.0 +/- 2.9 micrograms/l; AUC: 1193.0 +/- 213.7 micrograms.l-1.120 min-1) but this response was clearly lower (p < 0.0002) than that observed in NS (62.6 +/- 7.3 micrograms/l, 4587.5 +/- 614.9 micrograms.l-1.120 min-1).
2 context sentences(design, population, supporting numbers)
Summary · context
To further investigate this point, in eight male obese (OB) patients (27-49 years old; body mass index = 39.5 +/- 1.7 kg/m2) we studied the effect of oral glucose load (100 g) on the GH response to Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide belonging to the GH-releasing peptide fam…
Summary · context
As a control group, six male age-matched normal subjects (NS) were studied (26-35 years old; body mass index = 22.3 +/- 1.5 kg/m2).
Report a problemFND-0902571202
02HumanObservational studyActivity measurement
In obese patients and in normal subjects, hexarelin released more GH than GHRH.
In plain wordsIn obese and normal-weight men, hexarelin released more growth hormone than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin vs GHRH
Study
n = 14
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenous · single doseAs given in this study (human).
Source sentences
Summary
In OB patients as well as in normal subjects HEX releases more GH than GHRH.
2 context sentences(design, population, supporting numbers)
Summary · context
To further investigate this point, in eight male obese (OB) patients (27-49 years old; body mass index = 39.5 +/- 1.7 kg/m2) we studied the effect of oral glucose load (100 g) on the GH response to Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide belonging to the GH-releasing peptide fam…
Summary · context
As a control group, six male age-matched normal subjects (NS) were studied (26-35 years old; body mass index = 22.3 +/- 1.5 kg/m2).
Report a problemFND-0902571203
03HumanObservational studyActivity measurement
In obese men, hexarelin induced a clear GH rise.
In plain wordsIn obese men, hexarelin caused a clear rise in growth hormone.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin in obese patients
Study
n = 8
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenous · single doseAs given in this study (human).
Measurements
GH peak
20 micrograms/l
obese patients
Source sentences
Summary
Hexarelin induced a clear GH rise in OB (peak: 20.0 +/- 2.9 micrograms/l; AUC: 1193.0 +/- 213.7 micrograms.l-1.120 min-1)
2 context sentences(design, population, supporting numbers)
Summary · context
To further investigate this point, in eight male obese (OB) patients (27-49 years old; body mass index = 39.5 +/- 1.7 kg/m2) we studied the effect of oral glucose load (100 g) on the GH response to Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide belonging to the GH-releasing peptide fam…
Summary · context
As a control group, six male age-matched normal subjects (NS) were studied (26-35 years old; body mass index = 22.3 +/- 1.5 kg/m2).
Report a problemFND-0902571201

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

04HumanNot a test of Hexarelin aloneObservational studyActivity measurement
In obese patients, an oral glucose load failed to modify the GH response to hexarelin.
In plain wordsIn obese men, drinking glucose did not change the growth hormone response to hexarelin.
Peptide
Hexarelin
Outcome
No significant changeEffect of oral glucose on the GH response to hexarelin in obese patients
Study
n = 8
Comparator
Hexarelin without glucose
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak
19.4 micrograms/l
hexarelin after glucose, obese
Source sentences
Summary
but failed to modify it in OB (19.4 +/- 2.7 micrograms/l, 934.5 +/- 151.3 micrograms.l-1.
2 context sentences(design, population, supporting numbers)
Summary · context
To further investigate this point, in eight male obese (OB) patients (27-49 years old; body mass index = 39.5 +/- 1.7 kg/m2) we studied the effect of oral glucose load (100 g) on the GH response to Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide belonging to the GH-releasing peptide fam…
Summary · context
As a control group, six male age-matched normal subjects (NS) were studied (26-35 years old; body mass index = 22.3 +/- 1.5 kg/m2).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0902571205
05HumanNot a test of Hexarelin aloneObservational studyActivity measurement
In normal subjects, an oral glucose load significantly blunted the GH response to hexarelin (p < 0.05).
In plain wordsIn normal-weight men, drinking glucose reduced the growth hormone response to hexarelin.
Peptide
Hexarelin
Outcome
DecreaseEffect of oral glucose on the GH response to hexarelin in normal subjects
Study
n = 6
Comparator
Hexarelin without glucose
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH peak
38.4 micrograms/l
hexarelin after glucose, normal subjects
Source sentences
Summary
In NS, glucose significantly blunted the GH response to HEX (38.4 +/- 7.2 micrograms/l, 2236.5 +/- 514.8 micrograms.l-1.120 min-1, p < 0.05)
2 context sentences(design, population, supporting numbers)
Summary · context
To further investigate this point, in eight male obese (OB) patients (27-49 years old; body mass index = 39.5 +/- 1.7 kg/m2) we studied the effect of oral glucose load (100 g) on the GH response to Hexarelin (HEX, 2 micrograms/kg iv), a synthetic hexapeptide belonging to the GH-releasing peptide fam…
Summary · context
As a control group, six male age-matched normal subjects (NS) were studied (26-35 years old; body mass index = 22.3 +/- 1.5 kg/m2).
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0902571204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

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