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Study · Non-randomized trial · n = 6 · 1997

8 results

Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in man.

Arvat E, Di Vito L, Gianotti L, Ramunni J, Boghen MF, Deghenghi R, Camanni F, Ghigo E

Metabolism: clinical and experimental1 Jan 1997Cited by 19 (Europe PMC)

PMID9005975 (opens in a new tab)DOI10.1016/s0026-0495(97)90173-6 (opens in a new tab)PepBankPUB-09005975
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six normal young volunteers, the GH response to hexarelin was higher than the response to GHRH (P < .001).

    In plain wordsIn young healthy volunteers, hexarelin raised growth hormone more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release after hexarelin versus GHRH
    Study

    n = 6

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    The GH-releasing effect of HEX was higher than that of GHRH (area under the curve [AUC], 2,200.8 +/- 256.9 v 792.2 +/- 117.6 microg/L/h, P < .001
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

Studies that did not test the peptide alone7

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 02HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, hexarelin combined with GHRH induced a synergistic GH release, higher than the arithmetic sum of each alone (P < .02).

    In plain wordsIn young healthy volunteers, hexarelin and GHRH together raised growth hormone more than the sum of each alone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release after hexarelin plus GHRH
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    whereas combined administration of the two substances induced a true synergistic effect, with GH release after HEX plus GHRH (4,259.2 +/- 308.0 microg/L/h) being higher (P < .02) than the arithmetic sum of the GH increases induced by each compound separately administered.
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 03HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, previous rhGH administration blunted the GH response to hexarelin by 32.1% (P < .04).

    In plain wordsIn young healthy volunteers, a prior dose of growth hormone reduced the growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of rhGH pretreatment on GH response to hexarelin
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Inhibition of GH response
    32.1%
    hexarelin after rhGH

    Source sentences

    Summary
    After rhGH administration, the GH-releasing effect of HEX was blunted (1,468.9 +/- 193.7 microg/L/h, P < .04; inhibition of 32.1%
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 04HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, previous rhGH administration blunted the GH response to hexarelin plus GHRH by 26.7% (P < .02).

    In plain wordsIn young healthy volunteers, a prior dose of growth hormone reduced the response to hexarelin plus GHRH.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of rhGH pretreatment on GH response to hexarelin plus GHRH
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Inhibition of GH response
    26.7%
    hexarelin plus GHRH after rhGH

    Source sentences

    Summary
    The GH response to combined administration of HEX and GHRH was also blunted by the previous rhGH bolus (3,070.6 +/- 481.8 microg/L/h, P < .02; inhibition of 26.7%).
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  4. 05HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, pyridostigmine did not modify the GH response to hexarelin alone.

    In plain wordsIn young healthy volunteers, pyridostigmine did not change the growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of pyridostigmine on GH response to hexarelin
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    PD did not modify the GH-releasing effect of HEX either alone (2,456.8 +/- 317.5 microg/L/h) or combined with GHRH (4,009.1 +/- 360.8 microg/L/h)
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  5. 06HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, pyridostigmine did not modify the GH response to hexarelin combined with GHRH.

    In plain wordsIn young healthy volunteers, pyridostigmine did not change the response to hexarelin plus GHRH.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of pyridostigmine on GH response to hexarelin plus GHRH
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    PD did not modify the GH-releasing effect of HEX either alone (2,456.8 +/- 317.5 microg/L/h) or combined with GHRH (4,009.1 +/- 360.8 microg/L/h)
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  6. 07HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, rhGH blunted the GH response to hexarelin combined with pyridostigmine (P < .02).

    In plain wordsIn young healthy volunteers, a prior dose of growth hormone reduced the response to hexarelin plus pyridostigmine.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of rhGH on GH response to hexarelin plus pyridostigmine
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    rhGH was again able to blunt the GH response to HEX combined with PD (1,619.3 +/- 237.9 microg/L/h, P < .02)
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  7. 08HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In six normal young volunteers, rhGH failed to modify the GH response to hexarelin combined with GHRH and pyridostigmine.

    In plain wordsIn young healthy volunteers, a prior dose of growth hormone did not change the response to hexarelin, GHRH and pyridostigmine together.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of rhGH on GH response to hexarelin plus GHRH plus pyridostigmine
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    but failed to modify the GH response to HEX combined with GHRH and PD (4,548.4 +/- 698.0 microg/L/h)
    1 context sentence
    Summary · context
    To further clarify the mechanisms of action underlying the GH-releasing activity of HEX, in six normal young volunteers we studied the effects of rhGH (2 U intravenously [IV]) on the GH response either to GHRH (2 microg/kg IV) or to HEX (2 microg/kg IV) alone or combined with GHRH and/or pyridostigm…

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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