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Study · Randomized controlled trial · 1997

7 results

Oral desmopressin as a new treatment modality for primary nocturnal enuresis in adolescents and adults: a double-blind, randomized, multicenter study. Dutch Enuresis Study Group.

Janknegt RA, Zweers HM, Delaere KP, Kloet AG, Khoe SG, Arendsen HJ

The Journal of urology1 Feb 1997Cited by 29 (Europe PMC)

PMID8996345 (opens in a new tab)DOI10.1016/s0022-5347(01)65190-5 (opens in a new tab)PepBankPUB-08996345
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adolescents and adults with enuresis, oral desmopressin 200 and 400 micrograms did not differ significantly during the double-blind phase.

    In plain wordsIn adolescents and adults with enuresis, the two oral desmopressin doses did not differ significantly.

    Peptide
    Desmopressin
    Outcome
    No significant changeEfficacy during double-blind phase: 200 versus 400 micrograms oral
    Study

    n: not reported in source

    Comparator
    400 micrograms oral desmopressin
    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    200 and 400 micrograms · oral · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    No significant differences were found between the 2 doses of desmopressin tablets or between the tablets and 20 micrograms. nasal spray during the double-blind phase.
    2 context sentences
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adolescents and adults with enuresis, 200 micrograms oral desmopressin did not differ significantly from 20 micrograms nasal spray.

    In plain wordsIn adolescents and adults, oral desmopressin 200 micrograms did not differ significantly from nasal desmopressin 20 micrograms.

    Peptide
    Desmopressin
    Outcome
    No significant changeEfficacy during double-blind phase: 200 micrograms oral versus nasal
    Study

    n: not reported in source

    Comparator
    20 micrograms nasal desmopressin
    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    200 micrograms · oral · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    No significant differences were found between the 2 doses of desmopressin tablets or between the tablets and 20 micrograms. nasal spray during the double-blind phase.
    2 context sentences
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adolescents and adults with enuresis, 400 micrograms oral desmopressin did not differ significantly from 20 micrograms nasal spray.

    In plain wordsIn adolescents and adults, oral desmopressin 400 micrograms did not differ significantly from nasal desmopressin 20 micrograms.

    Peptide
    Desmopressin
    Outcome
    No significant changeEfficacy during double-blind phase: 400 micrograms oral versus nasal
    Study

    n: not reported in source

    Comparator
    20 micrograms nasal desmopressin
    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    400 micrograms · oral · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    No significant differences were found between the 2 doses of desmopressin tablets or between the tablets and 20 micrograms. nasal spray during the double-blind phase.
    2 context sentences
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.
  4. 04HumanNon-randomized trialEfficacy outcome

    In adolescents and adults initially receiving 200 micrograms, wet nights decreased after escalation to 400 micrograms during open treatment.

    In plain wordsIn adolescents and adults, wet nights decreased after oral desmopressin increased from 200 to 400 micrograms.

    Peptide
    Desmopressin
    Outcome
    DecreaseWet nights after dose escalation
    Study

    n: not reported in source

    Comparator
    Initial 200 micrograms oral dose
    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    400 micrograms · oral · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    However, patients who initially received 200 micrograms. desmopressin tablets experienced fewer wet nights after they completed 12 weeks of open label treatment when the dose was escalated to 400 micrograms. tablets.
    2 context sentences
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.
  5. 05HumanNon-randomized trialEfficacy outcome

    Adolescents and adults initially receiving 400 micrograms oral desmopressin maintained their response during open treatment.

    In plain wordsAdolescents and adults initially receiving 400 micrograms oral desmopressin maintained their response during open treatment.

    Peptide
    Desmopressin
    Outcome
    No significant changeResponse maintenance
    Study

    n: not reported in source

    Outcome group
    Urinary function · Kidney and urinary
    Studied dose
    400 micrograms · oral · 12 weeksAs given in this study (human).

    Source sentences

    Summary
    Those who received 400 micrograms. tablets initially maintained response during this phase.
    3 context sentences
    Summary · context
    However, patients who initially received 200 micrograms. desmopressin tablets experienced fewer wet nights after they completed 12 weeks of open label treatment when the dose was escalated to 400 micrograms. tablets.
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.
  6. 06HumanNon-randomized trialSafety outcome

    In adolescents and adults, 96% of patients rated desmopressin-tablet tolerability as excellent across both doses.

    In plain wordsIn adolescents and adults, 96% of patients rated desmopressin-tablet tolerability as excellent.

    Peptide
    Desmopressin
    Outcome
    Not applicablePatient-rated tolerability
    Study

    n: not reported in source

    Outcome group
    Adverse events · Kidney and urinary
    Studied dose
    200 and 400 micrograms · oralAs given in this study (human).

    Measurements

    Patients rating tolerability as excellent
    96%
    desmopressin tablets, both dose levels

    Source sentences

    Summary
    Desmopressin tablets were well tolerated at both dose levels: 96% of patients and 94% of physicians rated the tolerability as excellent.
    2 context sentences
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.
  7. 07HumanNon-randomized trialSafety outcome

    In adolescents and adults, 94% of physicians rated desmopressin-tablet tolerability as excellent across both doses.

    In plain wordsIn adolescents and adults, 94% of physicians rated desmopressin-tablet tolerability as excellent.

    Peptide
    Desmopressin
    Outcome
    Not applicablePhysician-rated tolerability
    Study

    n: not reported in source

    Outcome group
    Adverse events · Kidney and urinary
    Studied dose
    200 and 400 micrograms · oralAs given in this study (human).

    Measurements

    Physicians rating tolerability as excellent
    94%
    desmopressin tablets, both dose levels

    Source sentences

    Summary
    Desmopressin tablets were well tolerated at both dose levels: 96% of patients and 94% of physicians rated the tolerability as excellent.
    2 context sentences
    Summary · context
    A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms.
    Summary · context
    nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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