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Study · Randomized controlled trial · 1996

6 results

Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study.

Massoud AF, Hindmarsh PC, Brook CG

The Journal of clinical endocrinology and metabolism1 Dec 1996Cited by 22 (Europe PMC)

PMID8954038 (opens in a new tab)DOI10.1210/jcem.81.12.8954038 (opens in a new tab)PepBankPUB-08954038
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialActivity measurement

    In healthy adult males, hexarelin raised GH in a dose-dependent way, with a plateau of 140 mU/L at 1.0 microgram/kg and an ED50 of 0.48 microgram/kg.

    In plain wordsIn healthy men, higher doses of hexarelin released more growth hormone, up to a plateau at the 1.0 microgram/kg dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH dose-response (maximum GH response)
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0-1.0 microgram/kg · intravenous · single doseAs given in this study (human).

    Measurements

    GH plateau
    140 mU/L
    1.0 microgram/kg
    ED50
    0.48 microgram/kg
    GH

    Source sentences

    Summary
    The GH dose-response curve reached a plateau of 140 mU/L, corresponding to a hexarelin dose of 1.0 microgram/kg, with an ED50 of 0.48 +/- 0.02 microgram/kg (mean +/- SEM).
    1 context sentence
    Summary · context
    We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release.
  2. 02HumanRandomized controlled trialActivity measurement

    In healthy adult males, hexarelin raised prolactin in a dose-dependent way, with a plateau of 180% at 1.0 microgram/kg and an ED50 of 0.39 microgram/kg.

    In plain wordsIn healthy men, higher doses of hexarelin raised prolactin more, up to a plateau at the 1.0 microgram/kg dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin dose-response (maximum percent rise)
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    0-1.0 microgram/kg · intravenous · single doseAs given in this study (human).

    Measurements

    PRL plateau
    180%
    1.0 microgram/kg
    ED50
    0.39 microgram/kg
    PRL

    Source sentences

    Summary
    The PRL dose-response curve reached a plateau of 180% for the maximum percent rise from baseline, corresponding to a hexarelin dose of 1.0 microgram/kg, with an ED50 of 0.39 +/- 0.02 microgram/kg.
    1 context sentence
    Summary · context
    We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release.
  3. 03HumanRandomized controlled trialActivity measurement

    In healthy adult males, the cortisol dose-response curve showed a step increase to approximately 40% at a hexarelin dose of 0.5 microgram/kg.

    In plain wordsIn healthy men, hexarelin raised cortisol by about 40% at a dose of 0.5 microgram/kg.

    Peptide
    Hexarelin
    Outcome
    IncreaseCortisol dose-response (maximum percent change)
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones
    Studied dose
    0-1.0 microgram/kg · intravenous · single doseAs given in this study (human).

    Measurements

    cortisol rise
    ≈ 40%
    0.5 microgram/kg

    Source sentences

    Summary
    The cortisol dose-response curve showed a step increase to approximately 40% at a hexarelin dose of 0.5 microgram/kg.
    1 context sentence
    Summary · context
    We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release.

Studies that did not test the peptide alone3

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 04HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement

    In healthy adult males, GHRH-(1-29)-NH2 given with low-dose hexarelin resulted in massive GH release.

    In plain wordsIn healthy men, GHRH given together with a low dose of hexarelin released a very large amount of growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to low-dose hexarelin with GHRH
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH
    115 mU/L
    GHRH plus low-dose hexarelin

    Source sentences

    Summary
    The coadministration of GHRH-(1-29)-NH2 (1.0 microgram/kg) and low dose hexarelin (0.125 microgram/kg) resulted in massive GH release (115 +/- 32.8 mU/L)
    1 context sentence
    Summary · context
    We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 05HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement

    In healthy adult males, GHRH-(1-29)-NH2 given with low-dose hexarelin caused a moderate rise in serum prolactin.

    In plain wordsIn healthy men, GHRH given together with a low dose of hexarelin caused a moderate rise in prolactin.

    Peptide
    Hexarelin
    Outcome
    IncreaseProlactin response to low-dose hexarelin with GHRH
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    PRL rise
    84.9%
    GHRH plus low-dose hexarelin

    Source sentences

    Summary
    a moderate rise in serum PRL (84.9 +/- 27.5%)
    1 context sentence
    Summary · context
    We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 06HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement

    In healthy adult males, GHRH-(1-29)-NH2 given with low-dose hexarelin caused no rise in serum cortisol.

    In plain wordsIn healthy men, GHRH given together with a low dose of hexarelin did not raise cortisol.

    Peptide
    Hexarelin
    Outcome
    No significant changeCortisol response to low-dose hexarelin with GHRH
    Study

    n: not reported in source

    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    and no rise in serum cortisol.
    1 context sentence
    Summary · context
    We studied the effects of varying doses (0-1.0 microgram/kg) of hexarelin, a novel GH-releasing peptide, administered iv to healthy adult males on GH, PRL, and cortisol release.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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