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Study · Randomized controlled trial · n = 27 · 1996

6 results

Two-step gonadotropin-releasing hormone agonist treatment of uterine leiomyomas: standard-dose therapy followed by reduced-dose therapy.

Broekmans FJ, Hompes PG, Heitbrink MA, Netelenbos CC, Roos JC, Falke TM, Schoemaker J

American journal of obstetrics and gynecology1 Nov 1996Cited by 17 (Europe PMC)

PMID8942490 (opens in a new tab)DOI10.1016/s0002-9378(96)70030-3 (opens in a new tab)PepBankPUB-08942490
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with leiomyomas, uterine size fell further to 57.8% of baseline during randomized triptorelin treatment.

    In plain wordsIn women with leiomyomas, uterine size fell further during randomized triptorelin treatment compared with baseline.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseUterine size during randomized treatment
    Study

    n = 27

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100, 20, or 5 microgramsAs given in this study (human).

    Measurements

    Uterine size relative to baseline
    57.8 % of baseline
    after randomized triptorelin dose period

    Source sentences

    Summary
    During randomized treatment uterine size was further reduced to 57.8% of baseline.
    2 context sentences
    Summary · context
    Twenty-seven women with uterine leiomyomas were treated with a standard dose of triptorelin for 8 weeks.
    Summary · context
    Patients were then randomized to use 100, 20, or 5 micrograms of triptorelin until week 26.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with leiomyomas, overall volume reduction did not differ between triptorelin dose groups.

    In plain wordsIn women with leiomyomas, overall volume reduction was similar between triptorelin dose groups.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeVolume reduction between doses
    Study

    n = 27

    Comparator
    Other randomized triptorelin dose groups
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    There were no differences in overall volume reduction among the groups.
    2 context sentences
    Summary · context
    Twenty-seven women with uterine leiomyomas were treated with a standard dose of triptorelin for 8 weeks.
    Summary · context
    Patients were then randomized to use 100, 20, or 5 micrograms of triptorelin until week 26.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with leiomyomas, luteinizing hormone restoration during triptorelin treatment depended on dose.

    In plain wordsIn women with leiomyomas, luteinizing hormone restoration during triptorelin treatment depended on dose.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Direction not reportedLuteinizing hormone restoration
    Study

    n: not reported in source

    Comparator
    Other randomized triptorelin dose groups
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Luteinizing hormone and estradiol levels were restored in a dose-dependent way.
    2 context sentences
    Summary · context
    Twenty-seven women with uterine leiomyomas were treated with a standard dose of triptorelin for 8 weeks.
    Summary · context
    Patients were then randomized to use 100, 20, or 5 micrograms of triptorelin until week 26.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women with leiomyomas, estradiol restoration during triptorelin treatment depended on dose.

    In plain wordsIn women with leiomyomas, estradiol restoration during triptorelin treatment depended on dose.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Direction not reportedEstradiol restoration
    Study

    n: not reported in source

    Comparator
    Other randomized triptorelin dose groups
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Luteinizing hormone and estradiol levels were restored in a dose-dependent way.
    2 context sentences
    Summary · context
    Twenty-seven women with uterine leiomyomas were treated with a standard dose of triptorelin for 8 weeks.
    Summary · context
    Patients were then randomized to use 100, 20, or 5 micrograms of triptorelin until week 26.
  5. 05HumanRandomized controlled trialSafety outcome

    In women with leiomyomas, bone mineral density decreased significantly in the highest-dose triptorelin group at week 26.

    In plain wordsIn women with leiomyomas, bone mineral density decreased significantly in the highest-dose triptorelin group at week 26.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseBone mineral density at week 26
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 microgramsAs given in this study (human).

    Source sentences

    Summary
    Bone mineral density decreased significantly in the highest-dose group at week 26.
    2 context sentences
    Summary · context
    Twenty-seven women with uterine leiomyomas were treated with a standard dose of triptorelin for 8 weeks.
    Summary · context
    Patients were then randomized to use 100, 20, or 5 micrograms of triptorelin until week 26.
  6. 06HumanNon-randomized trialEfficacy outcome

    In women with leiomyomas, uterine size fell to 67.1% of baseline during standard-dose triptorelin treatment.

    In plain wordsIn women with leiomyomas, uterine size fell to 67.1% of baseline during standard-dose triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseUterine size during standard treatment
    Study

    n = 27

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Measurements

    Uterine size relative to baseline
    67.1 % of baseline
    standard-dose triptorelin, 8 weeks

    Source sentences

    Summary
    During standard treatment uterine size was reduced to 67.1% of baseline.
    1 context sentence
    Summary · context
    Twenty-seven women with uterine leiomyomas were treated with a standard dose of triptorelin for 8 weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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