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Study · Animal study (in vivo) · rat · 1996

8 results

Mechanism of action of Hexarelin. I. Growth hormone-releasing activity in the rat.

Torsello A, Grilli R, Luoni M, Guidi M, Ghigo MC, Wehrenberg WB, Deghenghi R, Müller EE, Locatelli V

European journal of endocrinology1 Oct 1996Cited by 8 (Europe PMC)

PMID8921832 (opens in a new tab)DOI10.1530/eje.0.1350481 (opens in a new tab)PepBankPUB-08921832
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In 10-day-old rat pups, hexarelin treatment for 3-10 days significantly enhanced, in a time-related way, the GH response to an acute hexarelin challenge.

    In plain wordsIn young rat pups, several days of hexarelin treatment increased the growth hormone response to a new hexarelin dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to acute hexarelin challenge after pretreatment
    Study

    ratn: not reported in source

    10-day-old pups
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    80 micrograms/kg b.i.d. · 3-10 daysAs given in this study (rat).

    Source sentences

    Summary
    In 10-day-old pups, treatments with HEXA (80 micrograms/kg, b.i.d.) for 3-10 days significantly enhanced, in a time-related fashion, the GH response to an acute HEXA challenge.
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups passively immunized against GHRH, hexarelin pretreatment had qualitatively similar enhancing effects on the GH response.

    In plain wordsIn rat pups with GHRH blocked, hexarelin pretreatment also increased the growth hormone response to a new dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to acute hexarelin challenge after pretreatment, GHRH-immunized pups
    Study

    ratn: not reported in source

    10-day-old pups immunized against GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Qualitatively similar effects were elicited in pups passively immunized against growth hormone-releasing hormone (GHRH) from birth.
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats, a 5-day hexarelin pretreatment did not enhance the effect of the acute challenge.

    In plain wordsIn adult male rats, five days of hexarelin pretreatment did not increase the growth hormone response to a new dose.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to acute challenge after 5-day pretreatment
    Study

    ratn: not reported in source

    Adult male rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    150 micrograms/kg b.i.d. · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In adult male rats, a 5-day pretreatment with HEXA (150 micrograms/kg, b.i.d.) did not enhance the effect of the acute challenge, and the same pattern was present after a 5-day pretreatment in male rats with surgical ablation of the mediobasal hypothalamus (MBH-ablated rats).
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats with ablation of the mediobasal hypothalamus, a 5-day hexarelin pretreatment also did not enhance the acute GH response.

    In plain wordsIn adult male rats with part of the hypothalamus removed, five days of hexarelin did not increase the growth hormone response to a new dose.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to acute challenge after 5-day pretreatment, MBH-ablated rats
    Study

    ratn: not reported in source

    Adult male rats with mediobasal hypothalamus ablation
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    150 micrograms/kg b.i.d. · 5 daysAs given in this study (rat).

    Source sentences

    Summary
    In adult male rats, a 5-day pretreatment with HEXA (150 micrograms/kg, b.i.d.) did not enhance the effect of the acute challenge, and the same pattern was present after a 5-day pretreatment in male rats with surgical ablation of the mediobasal hypothalamus (MBH-ablated rats).
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In adult sham-operated rats, hexarelin induced a greater GH response than GHRH.

    In plain wordsIn adult rats, hexarelin raised growth hormone more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin versus GHRH
    Study

    ratn: not reported in source

    Adult sham-operated rats
    Comparator
    GHRH 2 micrograms/kg i.v.
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    300 micrograms/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    In addition, in adult sham-operated rats, Hexarelin (300 micrograms/kg, i.v.) induced a GH response greater (p < 0.05) than that induced by GHRH (2 micrograms/kg, i.v.).
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats 7 days after mediobasal hypothalamus ablation, hexarelin was significantly less effective than GHRH at raising GH.

    In plain wordsIn rats with part of the hypothalamus removed a week earlier, hexarelin raised growth hormone less than GHRH did.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to hexarelin versus GHRH at 7 days after ablation
    Study

    ratn: not reported in source

    MBH-ablated rats, 7 days after surgery
    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in MBH-ablated rats 7 days after surgery, GHRH was significantly (p < 0.05) more effective than HEXA
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats 30 days after mediobasal hypothalamus ablation, hexarelin and GHRH evoked similar rises of plasma GH.

    In plain wordsIn rats with part of the hypothalamus removed a month earlier, hexarelin and GHRH raised growth hormone by similar amounts.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin versus GHRH at 30 days after ablation
    Study

    ratn: not reported in source

    MBH-ablated rats, 30 days after surgery
    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and 30 days after surgery HEXA and GHRH evoked similar rises of plasma GH.
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.
  8. 08LabIn vitro (cells)Efficacy outcome

    In vitro, the hexarelin effect on GH release was transient, while GHRH induced a longer-lasting and greater release.

    In plain wordsIn rat cell tests, hexarelin raised growth hormone only briefly, while GHRH gave a longer and larger release.

    Peptide
    Hexarelin
    Outcome
    MixedTime course of in vitro GH release versus GHRH
    Study

    ratn: not reported in source

    In vitro rat pituitary system
    Comparator
    GHRH 10(-8) mol/l
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10(-6) mol/lAs given in this study (rat).

    Source sentences

    Summary
    Finally, the in vitro Hexarelin (10(-6) mol/l) effect was transient while GHRH (10(-8) mol/l) induced a longer lasting and greater GH release.
    1 context sentence
    Summary · context
    This study was undertaken to further investigate Hexarelin's mechanisms of action.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

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