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Study · Not a test of the peptide alone · 1996

3 results

Correlations between biological activity and structural properties for two short homologous sequences in thymosin beta4 and gelsolin.

Feinberg J, Mery J, Heitz F, Benyamin Y, Roustan C

International journal of peptide and protein research1 Jan 1996Cited by 2 (Europe PMC)

PMID8907501 (opens in a new tab)DOI10.1111/j.1399-3011.1996.tb00811.x (opens in a new tab)PepBankPUB-08907501
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement

    In lab tests, synthetic gelsolin-related and thymosin beta4-related peptides both strongly inhibited salt-induced actin polymerization.

    In plain wordsIn lab tests, short peptides based on thymosin beta4 and gelsolin strongly blocked actin from assembling. This was not the full-length protein.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInhibition of salt-induced actin polymerization
    Study

    n: not reported in source

    synthetic peptides with actin
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    These two sequences exert a major inhibitory effect on salt-induced actin polymerization.
    1 context sentence
    Summary · context
    Gelsolin- and thymosin beta4-related peptides including the common motif were synthesized and their structural and functional properties studied.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism

    In lab tests, circular dichroism and infrared spectroscopy showed that the two synthetic peptides have some secondary structure in solution.

    In plain wordsIn lab tests, the two short peptides showed some folded structure in solution.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableSecondary structure of synthetic peptides in solution
    Study

    n: not reported in source

    synthetic peptides with actin
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    We used circular dichroism and Fourier-transform infrared spectroscopy to show that the two synthetic peptides present some secondary structure in solution.
    1 context sentence
    Summary · context
    Gelsolin- and thymosin beta4-related peptides including the common motif were synthesized and their structural and functional properties studied.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism

    In lab tests, trifluoroethanol induced alpha-helical structure in the thymosin-derived peptide, as seen with the full-length molecule.

    In plain wordsIn lab tests, a chemical agent made the thymosin-based short peptide fold into a helix, as seen with the full-length molecule.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAlpha-helical structure of the thymosin-derived peptide
    Study

    n: not reported in source

    synthetic peptides with actin
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    As far as the peptide derived from the thymosin sequence was concerned, alpha-helical structure was induced by trifluoroethanol as observed with the full-length molecule.
    1 context sentence
    Summary · context
    Gelsolin- and thymosin beta4-related peptides including the common motif were synthesized and their structural and functional properties studied.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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