Degradation kinetics of gonadorelin in aqueous solution.

Hoitink MA, Beijnen JH, Bult A, van der Houwen OA, Nijholt J, Underberg WJ

Journal of pharmaceutical sciences1 Oct 1996Cited by 11 (Europe PMC)

PMID8897270DOI10.1021/js9601187PepBankPUB-08897270

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

01LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
In aqueous solution, gonadorelin was most stable at pH 5-5.5, with a half-life of 70 days at 70 degrees C.
In plain wordsIn lab tests, gonadorelin in water was most stable at pH 5-5.5, with a half-life of 70 days at 70 degrees C.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicablepH of greatest stability and half-life
Study
n: not reported in source
aqueous solution
Outcome group
Formulation, delivery and stability · Pharmacology
Measurements
half-life
70 days
pH 5-5.5, 70 degrees C
Source sentences
Summary
Gonadorelin is most stable at pH 5-5.5 with a half-life of 70 days at 70 degrees C.
1 context sentence(design, population, supporting numbers)
Summary · context
Influences of gonadorelin concentration, pH, temperature, buffer ions, and ionic strength on the degradation kinetics were studied.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0889727001
02LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
In aqueous solution, the pH-rate profile of gonadorelin degradation had proton-, solvent- and hydroxyl-catalyzed parts that gave different degradation products.
In plain wordsIn lab tests, gonadorelin broke down in different ways at low, middle and high pH, and gave different breakdown products.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableDegradation products across pH
Study
n: not reported in source
aqueous solution
Outcome group
Formulation, delivery and stability · Pharmacology
Source sentences
Summary
The pH-log Kobs profile can be divided into three parts, a proton, a solvent, and a hydroxyl-catalyzed section, with different degradation products.
1 context sentence(design, population, supporting numbers)
Summary · context
Influences of gonadorelin concentration, pH, temperature, buffer ions, and ionic strength on the degradation kinetics were studied.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0889727002
03LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
In aqueous solution, the gonadorelin degradation rate constant followed the Arrhenius equation under acidic and alkaline conditions.
In plain wordsIn lab tests, gonadorelin broke down faster at higher temperature, in a predictable pattern under acidic and alkaline conditions.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Not applicableTemperature dependence of degradation rate
Study
n: not reported in source
aqueous solution
Outcome group
Formulation, delivery and stability · Pharmacology
Source sentences
Summary
The overall degradation rate constant as a function of the temperature under acidic and alkaline conditions obeys the Arrhenius equation.
1 context sentence(design, population, supporting numbers)
Summary · context
Influences of gonadorelin concentration, pH, temperature, buffer ions, and ionic strength on the degradation kinetics were studied.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0889727003
04LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
In aqueous solution, gonadorelin concentration and acetate, phosphate, borate and carbonate buffer concentrations did not influence the decomposition rate.
In plain wordsIn lab tests, the amount of gonadorelin and the amount of buffer salts did not change how fast gonadorelin broke down.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeEffect of gonadorelin and buffer concentration on degradation rate
Study
n: not reported in source
aqueous solution
Outcome group
Formulation, delivery and stability · Pharmacology
Source sentences
Summary
The gonadorelin concentration and the concentrations of acetate, phosphate, borate, and carbonate buffer have no influence on the decomposition rate of the analyte.
1 context sentence(design, population, supporting numbers)
Summary · context
Influences of gonadorelin concentration, pH, temperature, buffer ions, and ionic strength on the degradation kinetics were studied.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0889727004
05LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other
In aqueous solution, increasing ionic strength raised the gonadorelin degradation rate at pH 2 and lowered it at pH 9, with small influences.
In plain wordsIn lab tests, more salt in the water made gonadorelin break down faster at pH 2 and slower at pH 9, with small effects.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
MixedEffect of ionic strength on degradation rate
Study
n: not reported in source
aqueous solution
Outcome group
Formulation, delivery and stability · Pharmacology
Source sentences
Summary
Increasing ionic strength led to higher Kobs at pH 2 and lower Kobs at pH 9, but influences were relatively small.
1 context sentence(design, population, supporting numbers)
Summary · context
Influences of gonadorelin concentration, pH, temperature, buffer ions, and ionic strength on the degradation kinetics were studied.
In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).
Report a problemFND-0889727005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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