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Study · Randomized controlled trial · n = 6 · 1996

3 results

Influence of beta-adrenergic agonists and antagonists on the GH-releasing effect of Hexarelin in man.

Arvat E, Gianotti L, Ramunni J, DiVito L, Deghenghi R, Camanni F, Ghigo E

Journal of endocrinological investigation1 Jan 1996Cited by 12 (Europe PMC)

PMID8851688 (opens in a new tab)DOI10.1007/bf03347854 (opens in a new tab)PepBankPUB-08851688
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialActivity measurement

    In normal male volunteers, hexarelin induced a marked GH rise.

    In plain wordsIn healthy men, hexarelin caused a marked rise in growth hormone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin (AUC)
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenous · single doseAs given in this study (human).

    Measurements

    GH AUC
    4573.2 micrograms.min/L
    hexarelin alone

    Source sentences

    Summary
    HEX induced a marked GH rise (AUC, mean +/- SE: 4573.2 +/- 588.8 micrograms.min/L)
    1 context sentence
    Summary · context
    In 6 normal male volunteers (aged 22-27 yr) we studied the interaction of the maximally effective iv dose of Hexarelin (HEX, 2 micrograms/kg iv at 0 min) with atenolol (100 mg po at -60 min) or salbutamol (0.08 mg/kg po at -60 min), which are beta-adrenergic antagonist and agonist, respectively

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 02HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement

    In normal male volunteers, pretreatment with atenolol, a beta-adrenergic antagonist, left the GH response to hexarelin unchanged.

    In plain wordsIn healthy men, atenolol, a beta blocker, did not change the growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeEffect of atenolol on the GH response to hexarelin
    Study

    n = 6

    Comparator
    Hexarelin alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH AUC
    4706.2 micrograms.min/L
    atenolol before hexarelin

    Source sentences

    Summary
    which was unchanged by atenolol (4706.2 +/- 928.2 micrograms.min/L)
    1 context sentence
    Summary · context
    In 6 normal male volunteers (aged 22-27 yr) we studied the interaction of the maximally effective iv dose of Hexarelin (HEX, 2 micrograms/kg iv at 0 min) with atenolol (100 mg po at -60 min) or salbutamol (0.08 mg/kg po at -60 min), which are beta-adrenergic antagonist and agonist, respectively

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 03HumanNot a test of Hexarelin aloneRandomized controlled trialActivity measurement

    In normal male volunteers, pretreatment with salbutamol, a beta-adrenergic agonist, blunted the GH response to hexarelin (p < 0.03).

    In plain wordsIn healthy men, salbutamol, a beta agonist, reduced the growth hormone response to hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of salbutamol on the GH response to hexarelin
    Study

    n = 6

    Comparator
    Hexarelin alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH AUC
    2792.8 micrograms.min/L
    salbutamol before hexarelin

    Source sentences

    Summary
    but blunted by salbutamol (2792.8 +/- 618.0 micrograms.min/L, p < 0.03)
    1 context sentence
    Summary · context
    In 6 normal male volunteers (aged 22-27 yr) we studied the interaction of the maximally effective iv dose of Hexarelin (HEX, 2 micrograms/kg iv at 0 min) with atenolol (100 mg po at -60 min) or salbutamol (0.08 mg/kg po at -60 min), which are beta-adrenergic antagonist and agonist, respectively

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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